Robert E. Synovec


 “Real-Time Target Selection Optimization to Enhance Alignment of Gas Chromatograms,” T. I. Dearing, J. S. Nadeau, B. G. Rohrback, L.S. Ramos and R. E. Synovec, Talanta, 2011, 83, 738.

 

“Application of Comprehensive Two-Dimensional Gas Chromatography with Time-of-Flight Mass Spectrometry Method to Identify Potential Biomarkers of Perinatal Asphyxia in a Non-Human Primate Model,” A. C. Beckstrom, E. M. Humston, L. R. Snyder, R. E. Synovec and S. E. Juul, J. Chromatogr. A, 2011,1218, 1899.


“Utilizing a Constant Peak Width Transform for Isothermal Gas Chromatography,” J. S. Nadeau, R. B. Wilson, B. D. Fitz, J. T. Reed and R. E. Synovec, J. Chromatogr. A, 2011, 1218, 3718.


“Chemometric Analysis of GC-MS Data using Fast Retention Time Alignment via a Total Ion Current Shift Function,” J. S. Nadeau, B. W. Wright and R. E. Synovec, Talanta, 2010, 81, 120.


“Quantitative Assessment of Moisture Damage for Cacao Bean Quality using Two-Dimensional Gas Chromatography Combined with Time-of-Flight Mass Spectrometry and Chemometrics,” E. M. Humston, J. D. Knowles, A. McShea and R. E. Synovec,J. Chromatogr. A, 2010, 1217, 1963.


“Increasing Selectivity in Comprehensive Three-Dimensional Gas Chromatography via an Ionic Liquid Stationary Phase Column in One Dimension,” W. C. Siegler, J. A. Crank, D. W. Armstrong and R. E. Synovec, J. Chromatogr. A, 2010, 1217, 3144.


“Utilizing the Third Order Advantage with Isotope Dilution Mass Spectrometry,” E. M. Humston, J. C. Hoggard and R. E. Synovec, Anal. Chem., 2010, 82, 41.


“Development and Application of a Comprehensive Two-Dimensional Gas Chromatography with Time-of-Flight Mass Spectrometry Method for the Analysis of L-Methylamino-Alanine in Human Tissue,” L. R. Snyder, J. C. Hoggard, T. J. Montine and R. E. Synovec, J. Chromatogr. A, 2010, 1217, 4639.


“High-Speed, Temperature Programmable Gas Chromatography Utilizing a Microfabricated Chip with an Improved Carbon Nanotube Stationary Phase,” V. R. Reid, M. Stadermann, O. Bakajin and R. E. Synovec, Talanta, 2009, 77, 1420.


“Handling Within Run Retention Time Shifts in Two-Dimensional Chromatography Data using Shift Correction and Modeling,” T. Skov, J. C. Hoggard, R. Bro and R. E. Synovec, J. Chromatogr. A, 2009, 1216, 4020.


“Toward automated peak resolution in complete GC × GC–TOFMS chromatograms by PARAFAC,” J. C. Hoggard, W. C. Siegler and R. E. Synovec, J. Chemometrics, 2009, 23, 421.


“Chemometric Approaches in Two Dimensional Gas Chromatography,” J. C. Hoggard and R. E. Synovec, in Comprehensive Two Dimensional Gas Chromatography (L. Ramos, editor) in Wilson & Wilson’s Comprehensive Analytical Chemistry (D. Barcelo, editor), Elsevier, Oxford, UK, 2009, Volume 55, Chapter 5, pp. 107-122.


“Development of a GC x GC –TOFMS Method using SPME to Determine Volatile  Compounds in Cacao Beans,” E. M. Humston, Y. Zhang, G. F. Brabeck, A. McShea    and R. E. Synovec, J. Sep. Sci., 2009, 32, 2289.

 
“An Algorithm to Identify Cycling Yeast Metabolites in GCxGC-TOFMS Data,” R. E. Mohler, B. P. Tu, K. M. Dombek, J. C. Hoggard, E. T. Young and R. E. Synovec, J. Chromatogr. A, 2008, 1186, 401

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“Constituents with Independence from Growth Temperature for Bacteria using Pyrolysis-Gas Chromatography / Differential Mobility Spectrometry with Analysis of Variance and Principal Component Analysis,” S. Prasad, K. M. Pierce, H. Schmidt, J. V. Rao, R. Güth, R. E. Synovec, G. B. Smith and G. A. Eiceman, Analyst, 2008, 6, 760.


“High-Speed Gas Chromatography: The Importance of Instrumentation Optimization and the Elimination of Extra-Column Band Broadening,” V. R. Reid and R. E. Synovec, Talanta, 2008, 76, 703. 


“Characterization and Utilization of a Novel High-Temperature Triflate Ionic Liquid Stationary Phase for use in GC x GC,” V. R. Reid, J. A. Crank, D. W. Armstrong and R. E. Synovec, J. Sep. Sci., 2008, 31, 3429.

 
“Time-Dependent Profiling of Metabolites from Snf1 Mutant and Wild Type Yeast Cells,” E. M. Humston, K. M. Dombek, J. C. Hoggard, E. T. Young and R. E. Synovec, Anal. Chem., 2008, 80, 8002.


“Recent Advancements in Comprehensive Two-Dimensional Separations with Chemometrics,” K. M. Pierce, J. C. Hoggard, R. E. Mohler and R. E. Synovec, J. Chromatogr. A, 2008, 1184, 341. 

 
“Parallel Factor Analysis (PARAFAC) of Target Analytes in GC x GC-TOFMS Data: Automated Selection of a Model with an Appropriate Number of Factors,” J. C. Hoggard and R. E. Synovec, Anal. Chem., 2007, 79, 1611.

  
“Cyclic Changes in Metabolic State During the Life of a Yeast Cell,” B. P. Tu, R. E. Mohler, K. M. Dombek, E. T. Young R. E. Synovec and S. L. McKnight, PNAS, 2007, 104, 16886.


“Comprehensive Three-Dimensional Gas Chromatography with Parallel Factor Analysis,” N. E. Watson, W. C. Siegler, J. C. Hoggard and R. E. Synovec, Anal. Chem., 2007, 79, 8270. 


“Comprehensive Two-Dimensional Gas Chromatography Time-of-Flight Mass Spectrometry Analysis of Metabolites in Fermenting and Respiring Yeast Cells,” R. E. Mohler, K. M. Dombek, J. C. Hoggard, E. T. Young and R. E. Synovec, Anal. Chem., 2006, 78, 2700.


“Ultrafast Gas Chromatography on Single-Wall Carbon Nanotube Stationary Phases in Microfabricated Channels,” M. Stadermann, A. D. McBrady, B. Dick, V. R. Reid, A. Noy, R. E. Synovec and O. Bakajin, Anal. Chem., 2006, 78, 5639.


“Comprehensive Analysis of Yeast Metabolite GCxGC-TOFMS Data: Combining Discovery-Mode and Deconvolution Chemometric Software,” R. E. Mohler, K. M. Dombek, J. C. Hoggard, K. M. Pierce, E. T. Young and R. E. Synovec, Analyst, 2007,132, 756.


“Investigation of High-Speed Chromatography using Synchronized Dual-Valve Injection and Resistively Heated Temperature Programming,” V. R. Reid, A. D. McBrady and R. E. Synovec, J. Chromatogr. A, 2007, 1148, 236.


“Unsupervised Parameter Optimization for Automated Retention Time Alignment of Severely Shifted Gas Chromatographic Data using the Piecewise Alignment Algorithm,” K. M. Pierce, B. W. Wright and R. E. Synovec, J. Chromatogr. A, 2007, 1141, 106.


 “Observations on “Orthogonality” in Comprehensive Two-Dimensional Separations,” N. E. Watson, J. M. Davis and R. E. Synovec, Anal. Chem., 2007, 79, 7924.


“Classification of High Speed GC-MS Data by PCA Coupled with Piecewise Alignment and Feature Selection,” N. E. Watson, M. M. VanWingerden, K. M. Pierce, B. W. Wright and R. E. Synovec, J. Chromatogr. A, 2006, 1129, 111.


“Fisher Ratio Method Applied to Third Order Separation Data to Identify Significant Chemical Components of Metabolite Extracts,” K. M. Pierce, J. C. Hoggard, J. L. Hope, P. M. Rainey, A. N. Hoofnagle, R. M. Jack, B. W. Wright and R. E. Synovec, Anal. Chem., 2006, 78, 5068.


“Classification of Gasoline Data Obtained by Gas Chromatography using a Piecewise Alignment Algorithm combined with Feature Selection and Principal Component Analysis,” K. M. Pierce, J. L. Hope, K. J. Johnson, B. W. Wright and R. E. Synovec, J. Chromatogr. A, 2005, 1096, 101.

 
“A Comprehensive Two-Dimensional Retention Time Alignment Algorithm to Enhance Chemometric Analysis of Comprehensive Two-Dimensional Separation Data,” K. M. Pierce, L. F. Wood, B. W. Wright and R. E. Synovec, Anal. Chem., 2005, 77, 7735.


 “High-Speed GC using Synchronized Dual-Valve Injection,” G. M. Gross, B. J. Prazen, J. W. Grate and R. E. Synovec, Anal. Chem., 2004, 76, 3517.

Back to Research Interests

Awards & Activities

Amersham Pharmacia Professor in Residence, Molecular Dynamics, 2000


Visiting Faculty, Royal Golden Jubilee Ph.D. Program, Chiang Mai University, Chiang Mai, Thailand, 1999


DuPont Educational Aid Grant, DuPont, 1999


Excellence in Graduate Research Award, Iowa State University, 1986


Phillips Petroleum Fellowship in Analytical Chemistry, Iowa State University, 1985 - 1986


ACS Fellowship, ACS Division of Analytical Chemistry, 1984


Alpha Chi Sigma Graduate Research Award in Analytical Chemistry, Iowa State University, 1984

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