Department of ChemistryG. Dantas, A. L. Watters, B. Lunde, Z. Eletr, N. Isern, B. Kuhlman, B. L. Stoddard, G. Varani and D. Baker "Mistranslated progeny of a computationally-designed novel-fold protein forms a super-stable symmetric homodimer with zeptomolar affinity" J. Mol. Biology (2006)
T. Robertson and G. Varani "A simple, distance-dependent scoring function for prediction of protein-DNA interactions from structure" Proteins (2006)
"S. Reichow and G. Varani RNA switches function" Nature 441 1054-1055 (2006)
Y. Chen, J. Fender, J. D. Legassie, M. B. Jarstfer T. M. Bryan and G. Varani "The structure of stem-loop IV of Tetrahymena telomerase RNA identifies a conformational switch important for enzymatic activity" EMBO J. 25 3156-3166 (2006)
N. Dobson, G. Dantas, D. A. Baker and G. Varani "Complete computational redesign of human U1A protein: thermodynamic stabilization with high-resolution validation of protein structure and dynamics" Structure 14 847-856 (2006)
T. Hamma, S. L. Reichow, G. Varani and A. R. Ferré-D'Amaré "The Dyskerin-Nop10 complex: a conserved molecular bracket at the core of the box H/ACA snoRNP" Nature Struct Mol. Biol. 12 1101-1107 (2005)
T.C. Leeper, Z. Athanassiou, R.L.A. Dias, J.A. Robinson, and G. Varani "TAR RNA recognition by a cyclic peptidomimetic of Tat protein" Biochemistry 44 12362-12372 (2005)
Z. Shajani and G. Varani, "13^C NMR Relaxation Studies of RNA Base and Ribose Nuclei Reveal a Complex Pattern of Motions in the RNA Binding Site for Human U1A Protein" J. Mol. Biol. 349 699-715 (2005)
Y. Chen and G. Varani, "Protein Families and RNA Recognition FEBS J. 272 2088-2097 (2005)
P. Deka, J. M. Perez-Canadillas, R. K. Paranji and G. Varani, "Protein and RNA Dynamics Play a Key Role in Determining the Specific Recognition of GU-rich polyadenylation regulatory elements by human Cstf-64 protein"J. Mol. Biol. 347 719-733 (2005)
T. C. Leeper and G. Varani, "Structure of the enzyme-activating fragment of human telomerase RNA" RNA 11 394-403 (2005)
Y. Chen, T. Kortemme, T. Robertson, D. Baker and G. Varani, "A new hydrogen-bonding potential for the design of protein-RNA interactions predicts specific contacts and discriminated decoys." Nucleic Acids Res. 32 5147-5162 (2004)
C. Detering and G. Varani "Validation of automated docking programs for docking and database" J. Med. Chem. 47 4188-4201 (2004)
"A new α-helical extension promotes RNA-binding by the dsRBD of Rnt1p RNAse III" Nicolas Leulliot, Sophie Quevillon-Cheruel, Marc Graille, Herman van Tilbeurgh Thomas L Leeper, Thomas E Edwards, Snorri Sigurdsson, Natasha Rozenkrants Roland J. Nagel, Katherine S Godin, Manuel Ares, Jr., Gabriele Varani EMBO J 23 2468-2477 (2004)
"Structural Mimicry of Retroviral Tat Proteins by Constrained β-Hairpin Peptidomimetics: Ligands with High Affinity and Selectivity for Viral TAR RNA Regulatory Elements" Zafiria Athanassiou, Ricardo L. A. Dias, Kerstin Moehle, Neil Dobson, Gabriele Varani and John A. Robinson J. Am. Chem. Soc. 126 6906-6913 (2004)
B. Davis, M. Afshar, G. Varani, A. I. H. Murchie, J. Karn, G. Lentzen, M. Drysdale, J. Bower, A. J. Potter, I. D. Starkey, T. Swarbrick, and F. Aboul-ela. "Rational Design of Inhibitors of HIV-1 TAR RNA Through the Stabilization of Electrostatic Hot Spots" J. Mol. Biol. 336 343-356 (2004)
B. Kuhlman, G. Dantas, G. C. Ireton, G. Varani, B. L. Stoddard & D. Baker. "Design of a Novel Globular Protein Fold with Atomic Level Accuracy" Science 302 1364-1368 (2003)
C.-J. Park, S.-H. Bae, G. Varani, M.-K. Lee and B.-S. Choi "Differential Recognition of Viral Promoter Structures by RNA-Dependent RNA Polymerase from Influenza Virus" Nucleic Acid Res. 31 2824-2832 (2003) (with cover)
J-M. Perez-Canadillas and G. Varani "Recognition of GU-rich polyadenylation regulatory elements by human Cstf-64 protein" EMBO J. 22 2821-2830 (2003)
T. L. Leeper, N. Leulliot and G. Varani "The solution structure of an essential stem-loop of human telomerase RNA" Nucleic Acids Res. 31 2614-2621 (2003)
J. Greatorex, J. Gallego, G. Varani and A. "Lever Structure and stability of wild-type and mutant RNA internal loops from the SL-1 domain of the HIV-1 packaging signal" J. Mol. Biol. 322 543- (2002)
J. A. Collier, J. Gallego, R. Klinck, P. T. Cole, S. J. Harris, G. P. Harrison, F. Aboul-Ela, G. Varani, S. Walker: "A conserved RNA structure within the HCV IRES eIF3-binding site." Nat Struct Biol. 9 375-380 (2002)
J. Gallego and G. Varani "Targeting RNA with Small-Molecule Drugs: Therapeutic Opportunities and Chemical Challenges." Acc. Chem. Res. 34 836-843 (2001)
N. Leulliot and G. Varani "Current Topics in RNA-Protein Recognition: Control of Specificity and Biological Function through Induced Fit and Conformation Capture." Biochemistry 40, 7947-7955 (2001)
L. Varani, S. I. Gunderson, T. Mittermaier, L. Kay, D. Neuhaus, I. Mattaj and G. Varani "The NMR Structure of the 40 kDa Human U1A Ternary Complex Reveals the Basis of Cooperativity in U1A Inhibition of Poly(A) Polymerase" Nature Struct. Biol. 7 329-335 (2000) (with Cover, News and Views)
A. Zeffman, S. Hassard, A. Lever and G. Varani "Structure of a Conserved RNA Internal Loop from the HIV-1 Encapsidation Signal and Interaction with gag Protein", J. Mol. Biol. 297 877-893 (2000).
A. Ramos, S. Grunert, M. Proktor, M. Bycroft, D. St Johnston & G. Varani. "Structural basis for RNA Recognition by Drosophila Staufen Double-Stranded RNA-Binding Domains" EMBO J 19, 997-1009 (2000)
A. Mittermaier, L. Varani, D. Muhandiram, L. E. Kay and G. Varani. "Changes in sidechain and backbone dynamics identify determinants of specificity in RNA recognition by human U1A protein." J. Mol. Biol 294 967-979 (1999) (cover)
K-Y. Chang, G. Varani, S. Bhattacharya, H. Choi and W. H. McClain "Correlation between RNA Deformability and tRNA Aminoacylation" PNAS USA 96 11764-11769 (1999)
L. Varani, M. G. Spillantini, B. Ghetti, A. Klug, M. Goedert and G. Varani "Structure of Tau Exon 10 Splicing Regulatory Element RNA and Disruption by Frontotemporal Dementian and Parkinsonism Linked to Chromosome Mutations." PNAS USA 96, 8229-8234 (1999)
A. Ramos and G. Varani "A New Method to Detect Long-Range Protein-RNA Contacts: NMR Detection of Electron-Proton Relaxation Induced by Nitroxide Spin-Labelled RNA" J. Am. Chem. Soc. 120 10992-10993 (1998)
G. Varani and K. Nagai "RNA Recognition by RNP Proteins during RNA Processing and Maturation" Ann. Rev. Biophys. Biomol. Struct. 27 407-445 (1998)
F. H.-T. Allain, P. W. A. Howe, D. Neuhaus and G. Varani "Structural Basis for the RNA-Binding Specificity of Human U1A Protein" EMBO Journal 16 5764-5774 (1997)
K-Y. Chang and G. Varani "Nucleic Acids Structure and Recognition" Nature Struct. Biol. 4 854-859 (1997)
F. Hamy, G. Heizmann, E. Felder, G. Varani, F. Aboul-Ela, J. Lazdins, M. Walker, J. Karn and T. Klimkait "Identification of an Inhibitor of the Tat/TAR RNA Interaction that Effectively Suppresses HIV Replication" PNAS USA 94, 3548-3553 (1997)
F.-H. T. Allain, C. C. Gubser, P. W. A. Howe, K. Nagai, D. Neuhaus and G. Varani, "RNP Interaction Specificity Determined by RNA Folding during Complex Formation." Nature 380 646-650 (1996)
G. Varani, F. Aboul-ela and F. H.-T. Allain "NMR Investigations of RNA Structure" Prog. NMR Spectroscopy 29 51-127 (1996)
F. Aboul-ela, J. Karn and G. Varani, "The Structure of the Human Immunodeficiency Virus Type-1 TAR RNA Reveals Principles of RNA Recognition by Tat Protein." J. Mol. Biol. 253, 313-332 (1995) (cover)
G. Varani, "Exceptionally Stable Nucleic Acid Hairpins."Ann. Rev. Biophys. Biomol. Structure 24, 379-404 (1995)
P. W. A. Howe, K. Nagai, D. Neuhaus and G. Varani, "NMR Studies of U1 snRNA Recognition by the N-Terminal RNP Domain of the Human U1A Protein."EMBO J 13, 3873-3881 (1994)
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