Neural Development
Multiple CIBR investigators are studying the basic mechanisms of brain development using the methods of cell biology, biochemistry, molecular biology and genetics. Defects in brain development can lead to cognitive, motor, and intellectual disability, as well as neurodevelopmental disorders such as autism, epilepsy, hydrocephalus, spina bifida and several psychiatric disorders. Our goal is to leverage our basic science findings to better diagnose and develop novel therapies for treating or preventing neurodevelopmental disorders.
CIBR Investigators:
- Bill Dobyns, M.D
- Robert Hevner, M.D., PhD
- Kathleen Millen, Ph.D.
- Nino Ramirez, Ph.D.
- Eric Turner, M.D., PhD.
Current Projects:
- Human Cerebellar Malformations and genetic syndromes of brain overgrowth
- Mouse Models of Dandy Walker Malformation (DWM), Chiari Malformation and hydrocephalus
- Development of Dorsal Midline Central Nervous System Structures
- The roles of Brn3a, Islet1, and Hmx1 transcription factors in nervous system development
- Postnatal development of the respiratory network
- The roles of Tbr1 and Tbr2 in central nervous system neurogenesis