Brain Imaging
In collaboration with the University of Washington Integrated Brain Imaging Center (IBIC), Seattle Children’s Hospital , and SCRI’s Small Animal Tomographic Analysis (SANTA) Facility , CIBR investigators use neuroimaging tools to assess brain structure and function in a number of human neurodevelopmental and neurodegenerative disorders, as well as in animal models of human disorders. The most widely used research methods include quantitative assessment of structural MRI scans to ascertain shape and volumetric abnormalities in specific brain regions, functional MRI (fMRI) to explore abnormal brain activation in response to specific stimuli, and diffusion tensor imaging (DTI) to examine white matter integrity and connectivity
Principal Investigators:
- Elizabeth Aylward, PhD
- William Dobyns, MD
- Kathleen Millen, PhD
- Edward Novotny, MD
- Jeffrey Ojemann, MD
- Christian Roth, MD
- William Shain, PhD
Current Projects:
- Huntington’s Disease
- Autism
- Craniosynostosis and Plagiocephaly
- Human Cerebellar Malformations and genetic syndromes of brain overgrowth
- Mouse Models of Dandy Walker Malformation (DWM)
- Small Animal Imaging
- Bioimage Suite
- Advances in Confocal Microscopy
- Imaging of Brain Shunt Malfunction
- DTI and fMRI in Temporal Lobe Epilepsy
- Childhood Obesity and the Long Term Success of Treatment Procedures