Brain Imaging – Imaging of Brain Shunt Malfunction

 

Cell growth into hydrocephalus shunts is a critical problem resulting in frequent replacement in patients. We are investigating brain cell responses to these devices and means to control cell growth. In this study rabbits were implanted with catheters used in clinical treatment to study the impact of fluid flow on growth. Brain samples are being studied using a 14T MRI to obtain images with the highest possible resolution. We will correlate these images and signals with multiplexed confocal microscopy images and signals to correlate MRI signals to microscopically identified cell ingrowth.