To further explore mechanisms mediating these effects of vitamin D deficiency (VDD) on insulin resistance (IR) and NAFLD among overweight children, the Roth lab has developed a rat model of NAFLD induced by vitamin D deficiency and a westernized diet (high fat and high sugar intake). This model results in histologic features of NASH and is associated with up-regulation of hepatic inflammatory and oxidative stress genes as well as toll-like receptor/endotoxin signaling pathway. This work is being done in conjunction with Dr. Kris Kowdley at the Benaroya Research Institute.
Whats Happening at CIBR?
- “Anesthetic Activation of Endogenous Sleep-Promoting Neurons: Quirky Coincidence or Critical Cause of Hypnosis” with Max B. Kelz
- “The Allen Developing Mouse Brain Atlas: A high resolution spatiotemporal atlas of gene expression of the developing mouse brain” with Carol Thompson
- “Mapping the Mouse Brain Connectome” with Julie Harris