Hydrocephalus – Gene Discovery

 

New genomic technologies provide unprecedented opportunities to discover genetic factors that cause or contribute to hydrocephalus, from primary structural problems in the way the ventricular system is formed to genetically-determined differences in the way CSF is produced and absorbed.  In the Dobyns lab, we use whole-exome sequencing and related techniques to discover genes and pathways of interest associated with structural and functional brain problems.  With our collaborators, we can then explore the roles of those genes in cell cultures and animal models and use that information to deepen our understanding of the effects of those genes in people.