The Turner lab is using optogenetic mouse lines to examine the function of genetically defined neurons in the habenulopeduncular pathway linking the limbic system to the midbrain. Our emphasis is on the function of the medial habenula, about which very little is known. Recent evidence indicates that this pathway may mediate behavioral reponses to nicotine. Other lines of evidence suggest a role in motivated behavior, and in sleep. We will use mice expressing optogenetic channels to explore these functions in brain slice preparations and in behaving animals.
Whats Happening at CIBR?
- “Anesthetic Activation of Endogenous Sleep-Promoting Neurons: Quirky Coincidence or Critical Cause of Hypnosis” with Max B. Kelz
- “The Allen Developing Mouse Brain Atlas: A high resolution spatiotemporal atlas of gene expression of the developing mouse brain” with Carol Thompson
- “Mapping the Mouse Brain Connectome” with Julie Harris