Often referred to as “water on the brain”, hydrocephalus is a disorder in which an abnormal volume of cerebrospinal fluid (CSF) accumulates in the cranial cavity because of an imbalance between fluid production and absorption.  Genetic malformations, meningitis, subarachnoid hemorrhage, stroke, trauma, tumors, or unknown causes can restrict or completely block CSF flow and generate hydrocephalus.  Many cases are not due to obstruction and their cause remains unknown. Unfortunately, hydrocephalus is a debilitating disorder that afflicts 1 in 500 individuals, particularly children and the elderly.  Standard treatment involves implanting a silicone catheter and valve (shunt system) to drain CSF.  Although this type of treatment is usually effective in draining excess CSF temporarily, surgical revisions are often necessary due to shunt obstruction, infection, or over-drainage.

At Seattle Children’s Research Institute – Center for Integrative Brain Research, synergy and a collaborative atmosphere generate new ideas to understand and treat hydrocephalus.

CIBR Investigators

  • Samuel Browd, MD
  • William Dobyns, MD
  • Kathleen Millen, PhD
  • Jeff Ojemann, MD
  • William Shain, PhD
  • Hannah Tully, MD
  • Victor Chizhikov, PhD
  • Carolyn Harris, PhD

Current projects include:

Recent Publications in Hydrocephalus Click here

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