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Comparative Medicine

Carol B. Ware

Carol B. Ware

Carol B. Ware


Ph.D. National University of Ireland, Dublin 1986

South Lake Union, N501A, Box 358056, Seattle, WA 98195


About Dr. Ware

Dr. Ware’s research interests focus on pluripotent stem cells.  Currently this includes the stages of pluripotency and most recently, how pluripotency impacts DNA repair as a prelude to normal development and cancer.  She is the Director of the Tom and Sue Ellison Stem Cell Core within the Institute for Stem Cell and Regenerative Medicine (ISCRM) with a focus on human pluripotent stem cells, while pursuing an understanding of pluripotent cells from other mammalian species.  The Ellison Stem Cell Core facilitates research into stem cells by providing training, iPSC derivation and gene editing services.  It serves as a conduit for growth of local interest in stem cells, education and collaboration.  Dr. Ware jointly teaches a stem cell course  (CONJ 530) aimed primarily at graduate students beginning their research with stem cells.  In addition, she coordinates research updates, guest lectures and the annual symposium for ISCRM.  She is an Associate Director for ISCRM and is an Adjunct Professor in Oral Health Sciences.

Complete bibliography (selected publications out of 65)


Concise Review: Lessons from naïve human pluripotent cellsWare CB. Stem Cells. Epub 2016 PMID: 27663171


The metabolome regulates the epigenetic landscape during naïve-to-primed human embryonic stem cell transition. Sperber H, Mathieu J, Wang Y, Ferreccio A, Hesson J, Xu Z, Fischer KA, Devi A, Detraux D, Gu H, Battle SL, Showalter M, Valensisi C, Bielas JH, Ericson NG, Margaretha L, Robitaille AM, Margineantu D, Fiehn O, Hockenbery D, Blau CA, Raftery D, Margolin AA, Hawkins RD, Moon RT, Ware CB and Ruohola-Baker H.  Nature Cell Biol. 2015, 17:1523-1535 PMID: 26571212


Derivation of naïve human embryonic stem cells.  Ware CB, Nelson AM, Mecham B, Hesson J, Zhou W, Jonlin E, Jimenez-Caliani AJ, Deng X, Cavanaugh C, Cook S, Tesar PJ, Okada J, Margaretha L, Sperber H, Choi M, Blau CA, Treuting P, Hawkins RD, Cirulli V, Ruohola-Baker H.  Proc Natl Acad Sci. 2014, 111:4484-4489.  PMID: 24623855


Histone deacetylase inhibition elicits an evolutionarily conserved self-renewal program in embryonic stem cells.  Ware CB, Wang L, Mecham BH, Forough R, Nelson AM, Dauphin DS, Buckingham B, Bar M, Lim R, Askari B, Gartler SM, Shen L, Issa J-P, Tewari M, Lamba DA, Pavlidis P, Duan Z and Blau CA. Cell Stem Cell. 2009, 4:359-369. PMID: 19341625