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Denny Liggitt, D.V.M., Ph.D.
Professor and Chair
Department of Comparative Medicine
School of Medicine
University of Washington
P: 685-3256 / 543-8047
"My position as Chairman and Professor in the Department of Comparative Medicine (DCM), School of Medicine, University of Washington is oriented toward approximately 65% administrative, 15% service/teaching, 20% research. Teaching responsibilities are confined to formal seminar contacts and graduate student/post-doc/resident interactions. I am a board-certified veterinary pathologist with expertise in rodent pathology. Research interests are principally collaborative and directed toward projects involving, in a broad sense species and strain related variations, in-vivo interactions of the host with its defense and steady-state mechanisms and the role that selected cytokines and growth factors play in this interaction. I also have experience in the development and approval process for biologic and gene-based therapeutics hence some research and advisory efforts involve translational research with a pre-clinical emphasis."
Skerrett, S.J., Liggitt, H.D., Hajjar, A.M., Wilson, C.B. Myeloid differentiation factor 88 is essential for pulmonary host defense against Pseudomonas aeruginosa but not Staphylococcus aureus. J. Immunol. 172:3377-3381, 2004.
Xu, R., Johnson, A.J., Liggitt, D., Bevan, M.J. Cellular and humoral immunity against vaccina virus infection of mice. J. Immunol 172:6265-6271, 2004.
Fong, S., Liu, Y., Heath, T., Fong, P., Liggitt, D., Debs, R. Membrane permeant, DNA-binding agents target complexed plasmid DNA directly into the nucleus. Molecular Therapy 10:706-718, 2004.
Dow, S., Elmslie, R., Kurzman, I., Macewen, G., Pericle, F., Liggitt, D. Phase 1 study of liposome-DNA complexes encoding the interleukin-2 gene in dogs with osteosarcoma lung metastases. Hum Gene Ther 16:937-46, 2005.
Kharasch, E.D., Schroeder, J.L., Sheffels, P., Liggitt, H.D. Influence of sevoflurane on the metabolism and renal effects of compound A in rats. Anesthesiology 103:1183-1188, 2005.
Marie, JC, Liggitt, D, Rudensky, AY. Cellular mechanisms of fatal early-onset autoimmunity in mice with the T-cell specific targeting of tgf-beta receptor. Immunity 25:441-54, 2006.
Liu, Y, Liggitt, D, Fong, S, Debs, RJ. Systemic co-administration of depsipeptide selectively targets transfection enhancement to specific tissues and cell types. Gene Therapy 13:1724-30, 2006.
Cabbage, S.E., Huseby, E.S., Sather, B.D., Brabb, T., Liggitt, D., Goverman, J. Regulatory T cells maintain long-term tolerance to myelin basic protein by inducing a novel, dynamic state of T cell tolerance. J. Immunol. I178:887-96, 2007.
Harrington, R.D., Baszler, T.V., O’Rourke, K.I., Schneider, D.A., Spraker, T.R., Liggitt, H.D., Knowles, D.P. A species barrier limits transmission of chronic wasting disease to mink (Mustela vison). J Gen Virol 89(pt4):1086-96 , 2008.
Langdale, L.A. ,Hoagland, V., Benz, W., Riehle, K, J., Campbell, J.S. Liggitt, D., Fausto, N. Suppressor of Cytokine Signaling Expression with Increasing Severity of Murine Hepatic Ischemia-Reperfusion Injury Hepatology 49(2): 198-206, 2008
Gregorevic P, Schultz BR, Blankinship MJ, Meznarich NAK, Doremus C, Finn E, Allen JM, Kuhr CS, Haldorson JB, Liggitt, HD, Chamberlain JS. Evaluation of methodologies to enhance rAAV6-mediated gene transfer to canine musculature. Molecular Therapy 17:1427-1433, 2009.
Morris AE, Liggitt HD, Hawn TR, Skerret SJ. The role of toll-like receptor 5 in the innate immune response to acute P. aeruginosa pneumonia. Am J Physiol Lung Cell Mol Physiol. 297(6): L1112-9, 2009.