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Lillian Maggio-Price, V.M.D., Ph.D.
Professor, Vice Chairman
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Department of Comparative Medicine School of Medicine University of Washington Seattle, WA P: 685-3257 lmprice@uw.edu |
Lillian Maggio-Price is a laboratory animal veterinarian who oversees the Veterinary Services Unit in Comparative Medicine that administers veterinary medical care to research animals housed at the University of Washington. Dr. Maggio-Price’s research centers on microbial triggers of inflammation and cancer in the gastrointestinal tract and associated immunologic responses. Specifically, her laboratory has used genetically modified mutant mouse models to study the role of bacterial organisms, such as Helicobacter spp. to initiate and sustain dysregulated immune responses believed to characterize inflammatory bowel disease. Inflammatory bowel diseases in man (Crohn’s Disease and Ulcerative Colitis) are characterized by chronic and relapsing inflammatory intestinal disorders and are associated with a higher risk of colon cancer. Her current work using smad3-null mice with TGF-beta dysregulation have been useful to study the protective effects of dietary vitamin D in the development of colon cancer. Most recently research efforts have focused on how infectious agents, like noroviruses, can affect inflammatory diseases like inflammatory bowel disease and atherosclerosis.
Selected Publications
Willis CR, Seamons A, Maxwell J, Treuting P, Nelson L, Chen G, Phelps S, Smith CL, Brabb T, Iritani BM, Maggio-Price L. Interleukin-7 receptor blockade suppresses adaptive and innate inflammatory responses in experimental colitis. Journal of Inflammation 2012, 9:39 doi:10.1186/1476-9255-9-39 PMID:23057802
Hershberg RM, Ware C, Lei M, Maggio-Price L, Seamons A, Bielefeldt-Ohmann H, Zeng W, Brabb T. Lineage targeted MHC-II transgenic mice demonstrate the role of dendritic cell in bacterial-driven colitis. Inflamm Bowel Dis. 2012 May 22. doi: 10.1002/ibd.23000. PMID:22619032
Paik J, Fierce Y, Mai PO, McDonald T, Treuting P, Drivdahl R, Brabb T, LeBoeuf R, O’Brien KD, Maggio-Price L. Murine norovirus increases atherosclerotic lesion size and macrophages in Ldlr -/- mice Comparative Medicine 61:1-9, 2011.
Lencioni KC, Drivdahl R, Seamons A, Treuting PM, Brabb T, Maggio-Price L. Lack of effect of murine norovirus on a mouse model of bacterial-induced colon cancer. Comparative Medicine 61:219-226, 2011.
Ericsson, A., Myles, M., Davis, W., Ma, L., Lewis, M., Maggio-Price, L., and Franklin, C. Non-invasive detection of inflammation-associated colon cancer in a mouse model. Neoplasia 2010 Dec:12(12):1054-65.
Paik, J, Fierce, Y, Drivdahl, R, Treuting, PM, Seamons, A, Brabb, T and Maggio-Price, L. Effects of Murine Norovirus infection on a mouse model of diet-induced obesity and insulin resistance. Comparative Medicine 60:189-195, 2010.
Fleming, ES, Temchin, M., Wu, Q., Maggio-Price, L. and Tirnauer, JS. Spindle misorientation in tumors from APC(min/+) mice. Molecular Carcinogenesis 48:592-598, 2009.
Maggio-Price, L., Treuting, P., Bielefeldt-Ohmann, H., Seamons, A., Drivdahl, R., Zeng, W., Lai, L., Huycke, M., Phelps, S., Brabb, T., Iritani, B. Bacterial Infection of Smad3/Rag2 Double-Null Mice with Transforming Growth Factor – Dysregulation as a Model for Studying Inflammation-Associated Colon Cancer. American Journal of Pathology 174:317-329, 2009.
Lencioni, K.C., Seamons, A. Treuting, P., Maggio-Price, L., and Brabb, T. Murine Norovirus: An Intercurrent Variable in a Mouse Model of Bacteria-Induced Inflammatory Bowel Disease. Comparative Medicine 58(6):1-12, 2008.
Torrence, A.E., Brabb, T., Viney, J.L., Bielefeldt-Ohmann, H., Treuting, P., Seamons, A., Drivdahl, R., Zeng, W., Drivdahl R. and Maggio-Price, L. Serum Biomarkers in a Mouse Model of Bacterial-induced Inflammatory Bowel Diseases. Inflammatory Bowel Diseases 13:480-90, 2008.
Torrence, A.E., Brabb, T., Viney, J.L., Bielefeldt-Ohmann, H., Treuting, P., Seamons, A., Zeng, W. and Maggio-Price, L. Serum Biomarkers in a Mouse Model of Bacterial-induced Inflammatory Bowel Disease Inflammatory Bowel Disease 14:480-490, 2008.
Hale, L.P., Perera, D., Gottfried, M.R., Maggio-Price, L., Srinivasan, S, Burchette, J.L. and Marchuk, D. Neonatal Co-Infection with Helicobacter Species Markedly Accelerates the Development of Inflammation-Associated Colonic Neoplasia in IL-10-/- Mice. Helicobacter 12:598-604, 2007.
Maggio-Price L, Treuting P, Zeng W, Tsang M, Bielefeldt-Ohmann H and and Iritani BM. Helicobacter Infection Is Required for Inflammation and Colon Cancer in Smad3 Deficient Mice Cancer Research 66(2):1-11, 2006.
Maggio-Price L, Bielefeldt-Ohmann H, Treuting P, Iritani B, Zeng W, Nicks A, Tsang M, Shows D, Burich A, Shows D, Morrissey P and Viney J. Dual-infection with Helicobacter bilis and Helicobacter hepaticus promotes colonic dysplasia in multiple drug resistance deficient (mdr1a-/-) mice. American Journal of Pathology 166(6):1793-1806, 2005.
Maggio-Price, L., Shows, D., Waggie, K, Burich, A., Zeng, W., Morrissey, P. and Viney, J.L. Helicobacterbilis infection accelerates and Helicobacter hepaticus delays the development of colitis in multiple drug resistance (mdr1a) deficient mice. American Journal of Pathology 158(2):647-54, 2002.
Burich, A., Hershberg, R., Waggie, K., Zeng, W., Brabb, T., Westrich, G., Viney, J.L. an Maggio-Price, L. Helicobacter-induced inflammatory bowel disease in IL10-/- and T cell deficient mice. American Journal of Pathology. Gastrointest. Liver Physiol. 281:G764-G778, 2001.
