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Christina Pettan-Brewer, D.V.M., M.S.
Acting Instructor

Department of Comparative Medicine
School of Medicine
University of Washington
Seattle, WA

P: 685-4285

Veterinary Training
University Federal of Viçosa, Minas Gerais, Brazil
Doctor of Veterinary Medicine with Honors, Summa cum Laude.

School of Veterinary Medicine, University of California, Davis, California; Comparative Pathology and Zoo/Wildlife Medicine

Graduate School
School of Veterinary Medicine, University of California, Davis, California; Masters of Science in Comparative Pathology, Department of Pathology, Microbiology and Immunology

Faculty Appointments
1998 – Adjunct Faculty, Centenary College, Hackettstown, New Jersey
2009 – Senior Fellow/Acting Instructor, Department of Comparative Medicine
2010 – Acting Instructor, Department of Comparative Medicine

Research, Service and Teaching Interests

Christina Pettan-Brewer received her DVM in Brazil and moved to the US to pursue her career in Comparative Pathology. She worked at the Los Angeles Zoo before undertaking post-graduate studies at the University of California, Davis, under the direction of Drs. Linda J. Lowenstine and Murray E. Fowler in Comparative Pathology and Zoological and Wildlife Medicine. While at UC-Davis she developed many international professional collaborations with South America, including academic teaching and research programs at Sao Paulo Zoo, University of Sao Paulo and University Federal of Parana, Curitiba. Recently, she has been developing international collaborations with Japan as well.

Christina is an Acting Instructor in the Department of Comparative Medicine working in the research laboratory of Dr.Warren Ladiges. She is partially supported by a Diversity Supplement Award from the Nathan Shock Center of Excellence in the Biology of Aging, funded by the National Institute on Aging. The focus of Dr. Pettan-Brewer’s research is the basic biology of aging and age-related diseases, particularly cancer. She concentrates her studies on DNA damage and oxidative stress, genetic instability in different polymorphisms, and the investigation of DNA repair and antioxidant mechanisms during neoplastic progression. Dr. Pettan-Brewer’s new finding, showing that a single nucleotide mutation in the oxidant-sensitive DNA repair gene, XRCC1, suppresses tumor progression, is a major discovery that has great potential for application to translational research. She is also collaborating with other researchers on the use of small compounds that act as antioxidant mimetics for the amelioration of age-related tumor progression. An additional aspect of her interests and focus is to further develop her expertise in the pathobiology and physiology of aging mice. Her personal interests in zoological and wildlife medicine provide her with inspiration and direction for her research into human and domestic animal aging.

She mentors graduate and undergraduate students and actively participates in weekly lectures and seminars. She is the project leader at the UW of the Healthspan and Longevity Study, a collaborative study involving multiple investigators from the UW and University of San Antonio, Texas, sponsored by the National Institute of Aging. Currently she is involved in the development and implementation of a new support services center for investigators in mouse physiology, pathology (Physiology Assessment Center) and research in aging mice as animal models for longevity and healthspan studies.

Research Publications

Pettan, KCB, Jessup, DA, Lowenstine, LJ and NC Pedersen. Feline Leukemia Virus infection and Renal Spirochetosis in a free-ranging Cougar (Felis concolor). Journal of Zoo and Wildlife Medicine, 1993, 24(1):73-79.

Pettan, KCB, Drew, ML, Ramsay, E., Mohr, C. and LJ Lowenstine. Herpesvirus-like infection associated with Upper Respiratory Disease Syndrome in Desert Tortoises (Xerobates agassizii). Journal of Wildlife Diseases, 1996, 32(3):.521-526.

Pettan-Brewer, KCB and LJ Lowenstine. Intrahepatic Cysts and Hepatic Neoplasms in Felids, Ursids and other Zoo and Wild Animals. Chapter of the 4th Edition. Zoological and Wildlife Medicine, ed. Dr. Murray E. Fowler. W.B. Saunders Company. July 1998.

Furlong, CE., Cole TB, Jarvik GP, Pettan-Brewer C, Geiss GK, Richter RJ, Shih DM, Tward AD, Lusis AJ, Costa LG. Role of paraoxonase (PON 1) status in pesticide sensitivity: genetic and temporal determinants. Neurotoxicology 2005 aug 26(4): 651-9

Pettan-Brewer, C, Li Fu and S. S. Deeb. Distinguishing L from M photopigment coding sequences by hybridization to novel locked nucleic acid (LNA) oligonucleotide probes. Visual Neuroscience, Cambridge 2008; 25: 283-287.

Enns LC, Pettan-Brewer C, Ladiges WC. Protein Kinase A is a target for aging and the aging heart. Aging 2010 Apr 2(4):238-43

Goh, J, Enns, L, Fatamie, S, Hopkins H, Morton J, Pettan-Brewer C, Ladiges WC. Mitochondrial targeted catalase suppresses metastatic breast cancer in mice. (provisionally accepted) Breast Cancer Research.

Wiley, Jesse C, Pettan-Brewer C, Ladiges WC. Phenylbutyric Acid reduces amyloid plaques and rescues cognitive behavior in AD transgenic mice. (provisionally accepted) Aging Cell.

Pettan-Brewer C, Sidorova J, Morton J, Enns L, Goh J, Coil R, and Ladiges W. XRCC1 L360R DNA repair variant suppresses tumor progression and enhances alkylation-induced liver damage. In preparation to Cancer Research.

Department of Comparative Medicine
Magnuson Health Sciences Building
Room T-142, Box # 357190
Seattle, Washington 98195-7190
phone: (206) 543-8047
fax: (206) 685-3006

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