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Piper M. Treuting, D.V.M., M.S.
Department of Comparative Medicine
School of Medicine
University of Washington
Piper Meigs Treuting received her Doctorate of Veterinary Medicine from Louisiana State University in 1996 and began a post-doctoral fellowship in the UW Department of Comparative Medicine the same year. After receiving her Master of Science she joined the DCM faculty in the position of Chief of the Rodent Health Monitoring Program. Dr. Treuting received board certification in veterinary anatomic pathology by the American College of Veterinary Pathologists in September of 2001. Dr. Treuting serves as Chief of Comparative Pathology Services and co-directs UW Veterinary Diagnostic Laboratory and the Histology and Imaging Core (HIC). Dr. Treuting is the consulting comparative pathologist for the HIC.
Research, Service and Training Interests
Dr. Treuting’s overarching research interest is focused on the pathology of genetically modified mice and the use of mouse models in translational study of human disease. Her research areas center on mouse models in aging, inflammation and cancer.
Dr. Treuting and Dr. Suzy Dintzis (Department of Pathology) are the Editors in Chief and contributing authors of Comparative Anatomy and Histology: A Mouse and Human Atlas. This new reference text will be published in Nov. 2011. The atlas is aimed at the new mouse investigator as well as medical and veterinary pathologists who need to expand their knowledge base into comparative anatomy and histology. It guides the reader through normal mouse anatomy and histology using direct comparison to the human. The side by side comparison of mouse and human tissues highlight the unique biology of the mouse, which has great impact on the validation of mouse models of human disease.
Dr. Treuting coordinates the pathology coursework, rounds and rotations offered by the Department of Comparative Medicine (CMED 514, 512, 590; Thursday AFIP sessions). She co-coordinates the Biology and Diseases of Laboratory Animal course series (CMED 520/530 521/531), and the Biology of the Mouse (CMED 407). Dr. Treuting also trains and mentors select residents interested in achieving ACVP board certification. She is member of the coordinating faculty for the Jackson Laboratories Annual Workshops on the Pathology of Mouse Models for Human Disease.
Selected Recent Publications
Seamons A*, Treuting PM*, Brabb, T and Maggio-Price, L. Characterization of dextran sodium sulfate-induced inflammation and colonic tumorigenesis in Smad3-/- mice with dysregulated TGFβ. PLOS ONE. In Press.
Snyder JM and Treuting PM. Pathology in Practice. JAVMA. In Press.
Ward JM and Treuting PM. Rodent Intestinal Epithelial Carcinogenesis: Pathology and Preclinical Models. Toxicologic Pathology. 2013 Oct 31. [Epub ahead of print]
Disis ML, Gad E, Herendeen DR, Lai VP, Park KH, Cecil DL, O'Meara MM, Treuting PM, Lubet RA. A multi-antigen vaccine targeting neu, IGFBP-2 and IGF-IR prevents tumor progression in mice with pre-invasive breast disease. Cancer Prev Res (Phila). 2013 Oct 23. [Epub ahead of print]
Ladiges W, Ikeno Y, Liggitt D, Treuting PM. Pathology is a critical aspect of preclinical aging studies. Pathobiol Aging Age Relat Dis. 2013 Aug 20;3. doi: 10.3402/pba.v3i0.22451.
Tam VC, Suen R, Aderem A, Quehenberger O, Armando AM, Dennis EA, Treuting PM, Thomas PG, Oshansky-Weilnau CM. Lipidomic Profiling of Influenza Infection: Mediators Promoting Induction and Resolution of Inflammation. Cell. 2013 Jul 3;154(1):213-27.
Snyder JM, Molk DM, Treuting PM. Increased mortality in a colony of zebra finches exposed to continuous light. J Am Assoc Lab Anim Sci. 2013;52(3):301-7.
Paik J, Fierce Y, Treuting PM, Brabb T, and Maggio-Price L. High fat diet-induced obesity exacerbates inflammatory bowel disease in genetically susceptible Mdr1a-/- male mice. J Nutr. 2013 Jun 12. [Epub ahead of print]
Eken A, Singh AK, Treuting PM, Oukka M. IL-23R+ innate lymphoid cells induce colitis via interleukin-22-dependent mechanism. Mucosal Immunol. 2013 May 29. doi: 10.1038/mi.2013.33. [Epub ahead of print]
Delaney MA, Nagy L, Kinsel MJ, Treuting PM. Spontaneous Histologic Lesions of the Adult Naked Mole Rat (Heterocephalus glaber): A Retrospective Survey of Lesions in a Zoo Population. Vet Pathol. 2013 Jan 25.
Ramos HJ, Lanteri MC, Blahnik G, Negash A, Suthar MS, Brassil MM, Sodhi K, Treuting PM, Busch MP, Norris PJ, Gale M Jr. IL-1β signaling promotes CNS-intrinsic immune control of West Nile virus infection. PLoS Pathog. 2012;8(11):e1003039. doi: 10.1371/journal.ppat.1003039. Epub 2012 Nov 29.
Willis CR, Seamons A, Maxwell J, Treuting PM, Nelson L, Chen G, Phelps S, Smith CL, Brabb T, Iritani BM, Maggio-Price L. Interleukin-7 receptor blockade suppresses adaptive and innate inflammatory responses in experimental colitis. Inflamm (Lond). 2012 Oct 12;9(1):39. [Epub ahead of print]
Samstein RM, Josefowicz SZ, Arvey A, Treuting PM, Rudensky AY. Extrathymic generation of regulatory T cells in placental mammals mitigates maternal-fetal conflict. Cell. 2012 Jul 6;150(1):29-38. PubMed PMID: 22770213.
Sundberg JP, Hogenesch H, Nikitin AY, Treuting PM, Ward JM. Training mouse pathologists: ten years of workshops on the pathology of mouse models of human disease. Toxicol Pathol. 2012;40(5):823-5. Epub 2012 Mar 14.
Paik J, Fierce Y, Mai PO, Phelps SR, McDonald T, Treuting P, Drivdahl R, Brabb T, LeBoeuf R, O'Brien KD, Maggio-Price L. Murine norovirus increases atherosclerotic lesion size and macrophages in Ldlr(-/-) mice. Comp Med. 2011 Aug;61(4):330-8.
Josefowicz SZ, Niec RE, Kim HY, Treuting P, Chinen T, Zheng Y, Umetsu DT, Rudensky AY. Extrathymically generated regulatory T cells control mucosal T(H)2 inflammation. Nature. 2012 Feb 8. doi: 10.1038/nature10772. [Epub ahead of print]
Gall A, Treuting P, Elkon KB, Loo YM, Gale M Jr, Barber GN, Stetson DB. Autoimmunity Initiates in Nonhematopoietic Cells and Progresses via Lymphocytes in an Interferon-Dependent Autoimmune Disease. Immunity. 2012 Jan 27;36(1):120-31.
Brayton CF, Treuting PM, Ward JM. Pathobiology of Aging Mice and GEM: Background Strains and Experimental Design. Vet Pathol. 2012 Jan;49(1):85-105.
Treuting PM, Clifford CB, Sellers RS, Brayton CF. Of Mice and Microflora: Considerations for Genetically Engineered Mice. Vet Pathol. 2011 Dec 14.
Sellers RS, Clifford CB, Treuting PM, Brayton C. Immunological Variation Between Inbred Laboratory Mouse Strains: Points to Consider in Phenotyping Genetically Immunomodified Mice. Vet Pathol. 2011 Nov 30. [Epub ahead of print]