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Piper M. Treuting, D.V.M., M.S.
|Department of Comparative Medicine
School of Medicine
University of Washington
Piper Meigs Treuting received her Doctorate of Veterinary Medicine from Louisiana State University in 1996 and began a post-doctoral fellowship in the UW Department of Comparative Medicine the same year. After receiving her Master of Science she joined the DCM faculty in the position of Chief of the Rodent Health Monitoring Program. Dr. Treuting received board certification in veterinary anatomic pathology by the American College of Veterinary Pathologists in September of 2001. Dr. Treuting serves as Chief of Comparative Pathology Services and co-directs UW Veterinary Diagnostic Laboratory and the Histology and Imaging Core (HIC). Dr. Treuting is the consulting comparative pathologist for the HIC.
Research, Service and Training Interests
Dr. Treuting’s overarching research interest is focused on the pathology of genetically modified mice and the use of mouse models in translational study of human disease. Her research areas center on mouse models in aging, inflammation and cancer.
Dr. Treuting and Dr. Suzy Dintzis (Department of Pathology) are the Editors in Chief and contributing authors of Comparative Anatomy and Histology: A Mouse and Human Atlas. This new reference text will be published in Nov. 2011. The atlas is aimed at the new mouse investigator as well as medical and veterinary pathologists who need to expand their knowledge base into comparative anatomy and histology. It guides the reader through normal mouse anatomy and histology using direct comparison to the human. The side by side comparison of mouse and human tissues highlight the unique biology of the mouse, which has great impact on the validation of mouse models of human disease.
Dr. Treuting coordinates the pathology coursework, rounds and rotations offered by the Department of Comparative Medicine (CMED 514, 512, 590; Thursday AFIP sessions). She co-coordinates the Biology and Diseases of Laboratory Animal course series (CMED 520/530 521/531), and the Biology of the Mouse (CMED 407). Dr. Treuting also trains and mentors select residents interested in achieving ACVP board certification. She is member of the coordinating faculty for the Jackson Laboratories Annual Workshops on the Pathology of Mouse Models for Human Disease.
Selected Recent Publications
1: Samstein RM, Josefowicz SZ, Arvey A, Treuting PM, Rudensky AY. Extrathymic generation of regulatory T cells in placental mammals mitigates maternal-fetal conflict. Cell. 2012 Jul 6;150(1):29-38. PubMed PMID: 22770213.
2: Sundberg JP, Hogenesch H, Nikitin AY, Treuting PM, Ward JM. Training mouse pathologists: ten years of workshops on the pathology of mouse models of human disease. Toxicol Pathol. 2012;40(5):823-5. Epub 2012 Mar 14. PubMed PMID: 22421749.
3: Paik J, Fierce Y, Mai PO, Phelps SR, McDonald T, Treuting P, Drivdahl R, Brabb T, LeBoeuf R, O'Brien KD, Maggio-Price L. Murine norovirus increases atherosclerotic lesion size and macrophages in Ldlr(-/-) mice. Comp Med. 2011 Aug;61(4):330-8. PubMed PMID: 22330248; PubMed Central PMCID: PMC3155399.
4: Josefowicz SZ, Niec RE, Kim HY, Treuting P, Chinen T, Zheng Y, Umetsu DT, Rudensky AY. Extrathymically generated regulatory T cells control mucosal TH2 inflammation. Nature. 2012 Feb 8;482(7385):395-9. doi: 10.1038/nature10772. PubMed PMID: 22318520.
5: Gall A, TreutingP, Elkon KB, Loo YM, Gale M Jr, Barber GN, Stetson DB. Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease. Immunity. 2012 Jan 27;36(1):120-31. PubMed PMID: 22284419; PubMed Central PMCID: PMC3269499.
6: Brayton CF, Treuting PM, Ward JM. Pathobiology of aging mice and GEM: background strains and experimental design. Vet Pathol. 2012 Jan;49(1):85-105. PubMed PMID: 22215684.
7: Treuting PM, Clifford CB, Sellers RS, Brayton CF. Of mice and microflora: considerations for genetically engineered mice. Vet Pathol. 2012 Jan;49(1):44-63. Epub 2011 Dec 14. PubMed PMID: 22173977.
8: Sellers RS, Clifford CB, Treuting PM, Brayton C. Immunological variation between inbred laboratory mouse strains: points to consider in phenotyping genetically immunomodified mice. Vet Pathol. 2012 Jan;49(1):32-43. Epub 2011 Nov 30. PubMed PMID: 22135019.
9: Mather C, Treuting P. Onchocerca armillata contamination of a bovine pericardial xenograft in a human patient with repaired tetralogy of Fallot.Cardiovasc Pathol. 2012 May-Jun;21(3):e35-8. Epub 2011 Aug 9. PubMed PMID: 21831660.
10: Lencioni KC, Drivdahl R, Seamons A, Treuting PM, Brabb T, Maggio-Price L. Lack of effect of murine norovirus infection on a mouse model of bacteria-induced colon cancer. Comp Med. 2011 Jun;61(3):219-26. PubMed PMID: 21819691; PubMed Central PMCID: PMC3123754.
11: Pettan-Brewer and Treuting P.M. Practical Pathology of Aging Mice. Pathobiology of Aging & Age-related Diseases. Pathobiology of Aging & Age-related Diseases 2011, 1: 7202
12: Chaudhry A, Samstein RM, Treuting P, Liang Y, Pils MC, Heinrich JM, Jack RS, Wunderlich FT, Brüning JC, Müller W, Rudensky AY. Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation. Immunity. 2011 Apr 22;34(4):566-78. PubMed PMID: 21511185; PubMed Central PMCID: PMC3088485.
13: Miao EA, Leaf IA, Treuting PM, Mao DP, Dors M, Sarkar A, Warren SE, Wewers MD, Aderem A. Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria. Nat Immunol. 2010 Dec;11(12):1136-42. Epub 2010 Nov 7. PubMed PMID: 21057511; PubMed Central PMCID: PMC3058225.
14: Treuting PM, Albertson TM, Preston BD. Case series: acute tumor lysis syndrome in mutator mice with disseminated lymphoblastic lymphoma. Toxicol Pathol. 2010 Apr;38(3):476-85. Epub 2010 Feb 26. PubMed PMID: 20190201.