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Carol Ware, BS, PhD
|Department of Comparative Medicine
UW Medicine at South Lake Union
Office Phone: 616-5143
Lab Phone: 221-0305
Carol Ware received her PhD in 1986 from the National University of Ireland, University College, Dublin in Embryology and Reproductive Physiology. She was a Research Fellow at the University of Wisconsin until 1988, where she studied embryonic stem cell derivation and nuclear transfer. She joined the Molecular Immunology group at Immunex as a Research Scientist and moved to the University of Washington in 1995 and is now Director of the Tom and Sue Ellison Stem Cell Core and Associate Director for the Institute of Stem Cell and Regenerative Medicine (ISCRM).
Embryonic stem cells (ESC) are pluripotent cells capable of self-renewing indefinitely in vitro and differentiating into a broad array of cell types. Thus, human (h)ESC provide a model system to understand "stemness". Through the ability to differentiate, ESC have the potential to provide access to human fetal development, appropriate cells to test pharmacological toxity and material for tissue transplantation therapies. Dr. Ware’s research is involved with improving both the self-renewal and differentiation capacity of pluripotent stem cells. Current research explores epigenetic control of self-renewal and the ability to toggle between pluripotent states.
The Ellison Stem Cell Core facilitates research for all ISCRM affiliated investigators by providing training in ESC culture and iPSC derivation and assistance with initial studies to gage the value of pluripotent cells as a model for individual research projects. The core serves as a conduit for a number of ISCRM sponsored educational activities.
|Angel M. Nelson
Research Scientist III
Research Scientist II
Research Scientist I
Ware CB, Horowitz MC, Renshaw BR, Hunt JS, Liggitt D, Koblar SA, Gliniak BC, McKenna HJ, Papayannopoulou T, Thoma B, Donovan PJ, Peschon JJ, Bartlett PF, Willis CR, Wright BD, CarpenterMK, Davison BL and Gearing DP. (1995) Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death. Development 121:1283-1299.
Ware CB, Nelson AM and Liggitt D. (2003) Late Gestation Modulation of Fetal Glucocorticoid Effects Requires the Receptor for Leukemia Inhibitory Factor: An Observational Study. Reprod Biol Endocrinol 1:43.
Ware CB, Nelson AM and Blau CA. (2005) Controlled-rate freezing of human ES cells. Bio Techniques 38:879-833.
Ware CB, Nelson AM and Blau CA. (2006) A comparison of NIH-approved ES cell lines. Stem Cells 24:2677-2684.
Hall LL, Byron M, Butler J, Becker KA, Nelson A, Amit M, Itskovitz-Eldor J, Stein J, Stein G, Ware C and Lawrence JB (2008) X-inactivation reveals epigenetic anomalies in most hESC but identifies sublines that initiate as expected. J Cell. Physiol 216:445-452.
Chang KH, Nelson AM, Fields PA, Hesson JL, Ulyanova T, Cao H, Nakamoto B, Ware CB and Papayannopoulou T. (2008) Diverse hematopoietic potentials of five human embryonic stem cell lines. Exp Cell Res 314:2930-40.
Ware CB, Wang L, Mecham BH, Forough R, Nelson AM, Dauphin DS, Buckingham B, Bar M, Lim R, Askari B, Gartler SM, Shen L, Issa J-P, Tewari M, Lamba DA, Pavlidis P, Duan Z and Blau CA (2009) Histone deacetylase inhibition elicits an evolutionarily conserved self-renewal program in embryonic stem cells. Cell Stem Cell 4:359-369.
Qi J, Yu JY, Shcherbata HR, Mathieu J, Wang AJ, Seal S, Zhou W, Stadler BM, Bourgin D, Wang L, Nelson A, Ware C, Raymond C, Lim LP, Magnus J, Ivanovska I, Diaz R, Ball A, Cleary MA, Ruohola-Baker H. (2009) microRNAs regulate human embryonic stem cell division. Cell Cycle 8:3729-41. PMID: 19823043