DCM Department of Comparative Medicine

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Warren C. Ladiges, D.V.M, M.S.
Professor

Department of Comparative Medicine
School of Medicine
University of Washington
Seattle, WA 98195
email: wladiges@uw.edu

Veterinary training: Washington State University, School of Veterinary Medicine.

Military Service: Research Officer, United States Army Medical Research and Nutrition Laboratory, Fitzsimons Army Medical Center, Denver, CO.

Residency: University of Washington, Seattle, WA., Laboratory Animal Medicine and Pathology. Diplomate, American College of Laboratory Animal Medicine.

Postdoctoral Fellowship: Fred Hutchinson Cancer Research Center, Seattle, WA.

Faculty Appointments:

Assistant Professor, Department of Pathology, School of Medicine, University of Colorado, Denver, CO.

Professor, Department of Comparative Medicine, School of Medicine, University of Washington, Seattle, WA.

Administrative and Service Activities:

Editor-in-Chief, Pathobiology of Aging and Age-related Diseases

Oncology Merit Review Group, Dept of Veterans Affairs

External Advisory Board, Mutant Mouse Resource Centers, NIH

Director:

Transgenic Resources Program

Physiology and Aging Core

Patient Derived Xenograft Cancer Core

Research focus- Biology of aging and cancer:

1. Administrative Responsibilities

Editor-in-Chief:

Pathobiology of Aging and Age-related Diseases

Oncology Merit Review Group, Dept of Veterans Affairs

External Advisory Board, Mutant Mouse Resource Centers, NIH

Director:

Transgenic Resources Program

Physiology and Aging Core

Patient Derived Xenograft Cancer Core

2.Research Program

Research efforts are focused on investigation of the biology of aging with a specific interest in age-associated cancer such as breast cancer. There are several currently funded ongoing research projects.

The first project is based on the concept that reduction of oxidative stress via mitochondrial overexpression of catalase can reduce the progression of age-associated cancer in mice with the aim of investigating the mechanisms and developing clinical intervention applications.

A second project is designed to further investigate preliminary observations that mitochondrial catalase suppresses metastatic disease in a mouse model of metastatic breast cancer.

A third project is focused on studying the effects of exercise training on cancer development and tumor progression and invasiveness in mouse models of metastatic breast cancer.

A fourth project is designed to assess the physiological effects of aging in different strains of mice. Old mice and young mice are being tested for heart function, blood pressure, cognition, strength capacity, running ability, metabolic status, fat mass, lean mass, coordination, anxiety, and cataract development.

Recent Publications and Presentations

Wiley, JC, Pettan-Brewer KC, Treuting PM, Ladiges WC. Increased cognition and decreased plaque formation in APP/Psen1 transgenic mice treated with phenylbutyric acid. Aging Cell, 2011 Jan 27 [Epub ahead of print].

Goh J, Enns L, Fatemie S, Hopkins H, Morton J, Pettan-Brewer C, Ladiges W. Mitochondrial targeted catalase suppresses invasive breast cancer in mice. BMC Cancer, in press.

Pettan-Brewer C, Morton J, Enns L, Kehrli KRM, Sidorova J, Goh J, Coil R, Hopkins H, and Ladiges WC. Tumor progression is delayed in mice expressing a truncated XRCC1 protein. Am J Cancer Research, in press.

Pettan-Brewer KC, Morton J, Mangalindan RS, Ladiges W. Dietary modulation of the DNA repair gene XRCC1 in APC Min mice fed a high fat diet. Pathobiology of Aging, in press.

Ladiges W. Pathobiology of Aging. A new look at an old problem. Pathobio of Aging and Age-related Dis, in press.

Ladiges W. Anti-oxidant directed polarization of macrophages in age-related cancer. San Antonio Nathan Shock Aging Center 2011 Conference on Aging.

3.Teaching

Students are taught on a one-on-one basis how to design and conduct a short (three months) research project that incorporates objectives of ongoing research efforts described in our Research Program (see above).

A new course is being developed to be offered beginning in 2012 that will focus on the latest research findings on the relationship between diet, exercise and cancer in an interactive group discussion format.