Department of Comparative Medicine School of Medicine University of Washington Seattle, WA 98195 email: lmprice@uw.edu

Lillian Maggio-Price is a laboratory animal veterinarian who oversees the Veterinary Services Unit in Comparative Medicine that administers veterinary medical care to research animals housed at the University of Washington. Dr. Maggio-Price’s research centers on microbial triggers of inflammation and cancer in the gastrointestinal tract and associated immunologic responses. Specifically, her laboratory has used genetically modified mutant mouse models to study the role of bacterial organisms, such as Helicobacter spp. to initiate and sustain dysregulated immune responses believed to characterize inflammatory bowel disease. Inflammatory bowel diseases in man (Crohn’s Disease and Ulcerative Colitis) are characterized by chronic and relapsing inflammatory intestinal disorders and are associated with a higher risk of colon cancer. Her current work using smad3-null mice with TGF-beta dysregulation have been useful to study and help understand the role of intestinal microorganisms and immunologic responses in the progression of inflammation to cancer.

Selected Publications and Presentations

Maggio-Price, L. , Treuting, P., Bielefeldt-Ohmann, H., Seamons, A., Drivdahl, R., Zeng, W., Lai, L., Huycke, M., Phelps, S., Brabb, T., Iritani, B. Bacterial Infection of Smad3/Rag2 Double-Null Mice with Transforming Growth Factor – Dysregulation as a Model for Studying Inflammation-Associated Colon Cancer. American Journal of Pathology, (in press).

Lencioni, K.C., Seamons, A. Treuting, P., Maggio-Price, L., and Brabb, T. Murine Norovirus: An Intercurrent Variable in a Mouse Model of Bacteria-Induced Inflammatory Bowel Disease. Comparative Medicine 58(6):1-12, 2008.

Torrence, A.E., Brabb, T., Viney, J.L., Bielefeldt-Ohmann, H., Treuting, P., Seamons, A., Drivdahl, R., Zeng, W., Drivdahl R. and Maggio-Price, L. Serum Biomarkers in a Mouse Model of Bacterial-induced Inflammatory Bowel Disease. Inflammatory Bowel Diseases 13:480-90, 2008.

Maggio-Price L , Treuting P, Zeng W, Tsang M, Bielefeldt-Ohmann H and and Iritani BM. Helicobacter Infection Is Required for Inflammation and Colon Cancer in Smad3 Deficient Mice Cancer Research 66(2):1-11, 2006.

Maggio-Price L , Bielefeldt-Ohmann H, Treuting P, Iritani B, Zeng W, Nicks A, Tsang M, Shows D, Burich A, Shows D, Morrissey P and Viney J. Dual-infection with Helicobacter bilis and Helicobacter hepaticus promotes colonic dysplasia in multiple drug resistance deficient (mdr1a-/-) mice. Am J Pathol 166(6):1793-1806, 2005.

Maggio-Price, L. Iritani, B., Bielefeldt-Ohmann, H., Zeng, W. and P Treuting. Bacterial infection in multiple drug resistance deficient (mdr1a-/-) mice results in colitis characterized by dysplasia and is associated with increased expression of c-myc and interleukin- 1a/b. APS Conference, Immunological and Pathophysiological Mechanisms in Inflammatory Bowel Disease. Snowmass, CO. September 8-11, 2004

Hershberg, R., Bielefeldt-Ohmann, H., Zeng, W., Ware, C. and Maggio-Price, L. Helicobacter infection to elucidate the role of MHC Class II and dendritic cells in inflammatory bowel disease in CD11c transgenic/MHCII/Rag2 deficient (CD11cTgRII) mice. APS Conference, Immunological and Pathophysiological Mechanisms in Inflammatory Bowel Disease. Snowmass, CO. September 8-11, 2004 .

Maggio-Price, L., Shows, D., Waggie, K, Burich, A., Zeng, W., Morrissey, P. and Viney, J.L. Helicobacterbilis infection accelerates and Helicobacter hepaticus delays the development of colitis in multiple drug resistance (mdr1a) deficient mice. Am J Pathol. 158(2):647-54, 2002.

Treuting, P.M., Chen, L.I., Buetow, B.S., Zeng, W., Birkebak, T., Seewaldt, V.L., Sommer, K., Emond, M., Maggio-Price, L. and Swisshelm, K. Retinoic Acid Receptor b 2 Inhibition of Metastasis in Mouse Mammary Gland Xenografts. Breast Cancer Research and Treatment 72:79-82, 2002.

Burich, A., Hershberg, R., Waggie, K., Zeng, W., Brabb, T., Westrich, G., Viney, J.L. and Maggio-Price, L. Helicobacter-induced inflammatory bowel disease in IL10-/- and T cell deficient mice. Am. J. Physiol. Gastrointest. Liver Physiol. 281:G764-G778, 2001.