Department of Comparative Medicine, University of Washington, T-140Q Health Science Center Box 357190, Seattle, WA 98195-7190 Phone: 206-616-6725 Email: treuting@uw.edu

Piper Meigs Treuting received her Doctorate of Veterinary Medicine from Louisiana State University in 1996 and began a post-doctoral fellowship in the University of Washington Department of Comparative Medicine the same year. In August of 2000 she received her Master of Science from the UW Department of Comparative Medicine and joined the faculty as a Senior Fellow in the position of Chief of the Rodent Health Monitoring Program. Dr. Treuting received board certification in veterinary anatomic pathology by the American College of Veterinary Pathologists in September of 2001. Since 2004 , Dr. Treuting has served as Chief of Pathological Services and co-directs UW Veterinary Diagnostic Laboratory where she is Chief of Pathological Services. In 2005 she joined the regular faculty of the Department of Comparative Medicine in 2005 as an assistant professor. In 2008, the South Lake Union Histology and Imaging Core (HIC) opened and Dr. Treuting serves as the consulting veterinary pathologist for the HIC users.

Research and Academic Interests:

Dr. Treuting’s overall research interest is focused on the pathology of genetically modified mice. Her focus is on aging and the use of mouse models in aging, specifically, the mitochondrial targeted catalase overexpressing mice (mCAT). These mice have increased health span and relatively resistant to non-hematological cancers, chemically induced and genetically-induced metastatic breast cancer relative to wild type littermates. Studies using these mice are on-going with focus on testing mitochondrial targeted antioxidant therapies for cancer and the mitochondrial theory of aging.

Other collaborative projects include mouse models of bacterially-induced colon cancer, T-regulatory cell function in vivo, and the role of the innate immune system in murine aging. Dr. Treuting coordinates the comparative pathology rotation (CMED 512), weekly comparative pathology rounds, and much of the pathology coursework offered by the Department of Comparative Medicine (CMED 514, 512, 590). She co-coordinates the Biology and Diseases of Laboratory Animal course series (CMED 520/530 521/531), and the Biology of the Mouse (CMED 407). She also participates in the Annual Workshops on the Pathology of Mouse Models for Human Disease coordinated by John Sundberg at the Jackson Laboratories. In the fall of 2010, this series will be held in Seattle.

Selected Publications:

1. Chaudhry A, Rudra D, Treuting P, Samstein RM, Liang Y, Kas A, Rudensky AY. CD4+ Regulatory T Cells Control TH17 Responses in a Stat3-Dependent Manner. Science. 2009 Oct 1. [Epub ahead of print]
2. Tina M. Albertson, Masanori Ogawa, James M. Bugni, Laura E. Hays, Yang Chen, Yanping Wang, Piper M. Treuting, John A. Heddle, Robert E. Goldsby, Bradley D. Preston.DNA polymerase ε and δ proofreading suppress discrete mutator and cancer phenotypes in mice. PNAS published online before print September 24, 2009.
3. Rudra D, Egawa T, Chong MM, Treuting P, Littman DR, Rudensky AY. Runx-CBFbeta complexes control expression of the transcription factor Foxp3 in regulatory T cells. Nat Immunol. 2009 Sep 20. [Epub ahead of print]
4. Linda C. Enns, John F. Morton, Piper M. Treuting, Mary J. Emond, Norman S. Wolf, G. S. McKnight, Peter S. Rabinovitch, Warren C. Ladiges (2009) Disruption of Protein Kinase A in Mice Enhances Healthy Aging. PLoS ONE 4(6): e5963.
5. Ladiges W, Van Remmen H, Strong R, Ikeno Y, Treuting P, Rabinovitch P, Richardson A. Lifespan extension in genetically modified mice. Aging Cell. 2009 May 22. [Epub ahead of print]
6. Voronina VA, Takemaru K, Treuting P, Love D, Grubb BR, Hajjar AM, Adams A, Li FQ, Moon RT. Inactivation of Chibby affects function of motile airway cilia. J Cell Biol. 2009 Apr 20;185(2):225-33. Epub 2009 Apr 13. PubMed PMID: 19364920.
7. Zheng Y, Chaudhry A, Kas A, Deroos P, Kim JM, Chu TT, Corcoran L, Treuting P, Klein U, Rudensky AY.Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses. Nature. 2009 Feb 1. [Epub ahead of print]
8. Maggio-Price L, Treuting P, Bielefeldt-Ohmann H, Seamons A, Drivdahl R, Zeng W, Lai L, Huycke M, Phelps S, Brabb T, Iritani BM. Bacterial infection of Smad3/Rag2 double-null mice with transforming growth factor-beta dysregulation as a model for studying inflammation-associated colon cancer. Am J Pathol. 2009 Jan;174(1):317-29.
9. Lencioni KC, Seamons A, Treuting PM, Maggio-Price L, Brabb T. Murine norovirus: an intercurrent variable in a mouse model of bacteria-induced inflammatory bowel disease. Comp Med. 2008 Dec;58(6):522-33.
10. Treuting PM, Linford NJ, Knoblaugh SE, Emond MJ, Morton JF, Martin GM, Rabinovitch PS, Ladiges WC. Reduction of age-associated pathology in old mice by overexpression of Catalase in mitochondria. J Gerontol A Biol Sci Med Sci. 2008 Aug;63(8):813-22.
11. Rubtsov YP, Rasmussen JP, Chi EY, Fontenot J, Castelli L, Ye X, Treuting P, Siewe L, Roers A, Henderson WR Jr, Muller W, Rudensky AY. Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity. 2008 Apr;28(4):546-58.
12. Rosenberger CM, Clark AE, Treuting PM, Johnson CD, Aderem A. ATF3 regulates MCMV infection in mice by modulating IFN-gamma expression in natural killer cells. Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2544-9. Epub 2008 Feb 11.
13. Torrence AE, Brabb T, Viney JL, Bielefeldt-Ohmann H, Treuting P, Seamons A, Drivdahl R, Zeng W, Maggio-Price L. Serum biomarkers in a mouse model of bacterial-induced inflammatory bowel disease. Inflamm Bowel Dis. 2008 Apr;14(4):480-90.
14. Cross DJ, Flexman JA, Anzai Y, Sasaki T, Treuting PM, Maravilla KR, Minoshima S. In vivo manganese MR imaging of calcium influx in spontaneous rat pituitary adenoma. AJNR Am J Neuroradiol. 2007 Nov-Dec;28(10):1865-71. Epub 2007 Oct 9.
15. Venkatesan RN, Treuting PM, Fuller ED, Goldsby RE, Norwood TH, Gooley TA, Ladiges WC, Preston BD, Loeb LA. Mutation at the polymerase active site of mouse DNA polymerase delta increases genomic instability and accelerates tumorigenesis. Mol Cell Biol. 2007 Nov;27(21):7669-82. Epub 2007 Sep 4.
16. Sather BD, Treuting P, Perdue N, Miazgowicz M, Fontenot JD, Rudensky AY, Campbell DJ. Altering the distribution of Foxp3(+) regulatory T cells results in tissue-specific inflammatory disease. J Exp Med. 2007 Jun 11;204(6):1335-47. Epub 2007 Jun 4.
17. Bollen AM, Baskin CR, Treuting PM. Urolithiasis in rats consuming a dl bitartrate form of choline in a purified diet. Comp Med. 2006 Aug;56(4):245; author reply 245-6.
18. Maggio-Price L, Treuting P, Zeng W, Tsang M, Bielefeldt-Ohmann H, Iritani BM. Helicobacter infection is required for inflammation and colon cancer in SMAD3-deficient mice. Cancer Res. 2006 Jan 15;66(2):828-38.
19. Maggio-Price L, Bielefeldt-Ohmann H, Treuting P, Iritani BM, Zeng W, Nicks A, Tsang M, Shows D, Morrissey P, Viney JL. Dual infection with Helicobacter bilis and Helicobacter hepaticus in p-glycoprotein-deficient mdr1a-/- mice results in colitis that progresses to dysplasia. Am J Pathol. 2005 Jun;166(6):1793-806.
20. Schriner SE, Linford NJ, Martin GM, Treuting P, Ogburn CE, Emond M, Coskun PE, Ladiges W, Wolf N, Van Remmen H, Wallace DC, Rabinovitch PS. Extension of murine life span by overexpression of catalase targeted to mitochondria. Science. 2005 Jun 24;308(5730):1909-11. Epub 2005 May 5.
21. Hukkanen RR, Richardson M, Wingfield JC, Treuting P, Brabb T. Avipox sp. in a colony of gray-crowned rosy finches (Leucosticte tephrocotis). Comp Med. 2003 Oct;53(5):548-52.
22. Treuting PM, Chen LI, Buetow BS, Zeng W, Birkebak TA, Seewaldt VL, Sommer KM, Emond M, Maggio-Price L, Swisshelm K. Retinoic acid receptor beta2 inhibition of metastasis in mouse mammary gland xenografts. Breast Cancer Res Treat. 2002 Mar;72(1):79-88