Lillian Maggio-Price, V.M.D., Ph.D. Associate Professor Department of Comparative Medicine School of Medicine University of Washington Seattle, WA 98195 email: lmprice@u.washington.edu

Lillian Maggio-Price is a laboratory animal veterinarian who oversees the Veterinary Services Unit in Comparative Medicine at the University of Washington. Dr. Maggio-Price’s research centers on microbial triggers of inflammation in the gastrointestinal tract and associated immunologic responses. Specifically, her laboratory has used genetically modified mutant mouse animal models to study the role of bacterial organisms, such as Helicobacter spp., to initiate and sustain dysregulated immune responses believed to characterize inflammatory bowel disease. Inflammatory bowel diseases in man (Crohn’s Disease and Ulcerative Colitis) are severe and chronic inflammatory intestinal disorders of uncertain etiology which are associated with a higher risk of colon cancer. Most recently her work centers on the role of gastrointestinal bacteria in colon cancer.

Selected Publications and Presentations

Maggio-Price, L. Iritani, B., Bielefeldt-Ohmann, H., Zeng, W. and P Treuting. Bacterial infection in multiple drug resistance deficient (mdr1a-/-) mice results in colitis characterized by dysplasia and is associated with increased expression of c-myc and interleukin- 1a/b. APS Conference, Immunological and Pathophysiological Mechanisms in Inflammatory Bowel Disease. Snowmass, CO. September 8-11, 2004

Hershberg, R., Bielefeldt-Ohmann, H., Zeng, W., Ware, C. and Maggio-Price, L. Helicobacter infection to elucidate the role of MHC Class II and dendritic cells in inflammatory bowel disease in CD11c transgenic/MHCII/Rag2 deficient (CD11cTgRII) mice. APS Conference, Immunological and Pathophysiological Mechanisms in Inflammatory Bowel Disease. Snowmass, CO. September 8-11, 2004 .

Maggio-Price, L., Shows, D., Waggie, K, Burich, A., Zeng, W., Morrissey, P. and Viney, J.L. Helicobacterbilis infection accelerates and Helicobacter hepaticus delays the development of colitis in multiple drug resistance (mdr1a) deficient mice. Am J Pathol. 158(2):647-54, 2002.

Treuting, P.M., Chen, L.I., Buetow, B.S., Zeng, W., Birkebak, T., Seewaldt, V.L., Sommer, K., Emond, M., Maggio-Price, L. and Swisshelm, K. Retinoic Acid Receptor b 2 Inhibition of Metastasis in Mouse Mammary Gland Xenografts. Breast Cancer Research and Treatment 72:79-82, 2002.

Burich, A., Hershberg, R., Waggie, K., Zeng, W., Brabb, T., Westrich, G., Viney, J.L. and Maggio-Price, L. Helicobacter-induced inflammatory bowel disease in IL10-/- and T cell deficient mice. Am. J. Physiol. Gastrointest. Liver Physiol. 281:G764-G778, 2001.