Piper Meigs Treuting, D.V.M., M.S. Department of Comparative Medicine, University of Washington, T-140Q Health Science Center Box 357190, Seattle, WA 98195-7190 Phone: 206-616-6725 Email: treuting@u.washington.edu

Piper Meigs Treuting received her Doctorate of Veterinary Medicine from Louisiana State University in 1996 and began a post-doctoral fellowship in the University of Washington Department of Comparative Medicine the same year. In August of 2000 she received her Master of Science from the UW Department of Comparative Medicine and joined the faculty as a Senior Fellow in the position of Chief of the Rodent Health Monitoring Program. Dr. Treuting received board certification in veterinary anatomic pathology by the American College of Veterinary Pathologists in September of 2001. Currently, Dr. Treuting co-directs UW Veterinary Diagnostic Laboratory where she is Chief of Pathological Services. Additionally, Dr. Treuting serves as the consulting veterinary pathologist for the South Lake Union Histology and Imaging Core which is slated to be opened in September, 2008.

Research and Academic Interests

Dr. Treuting’s overall research interest is focused on the pathology of genetically modified mice. Current collaborative projects include mouse models of colon cancer, Helicobacter-associated pathology in rodents, the role of retinoids in breast cancer and aging in mice genetically resistant to oxidative stress, among others. Dr. Treuting coordinates the comparative pathology rotation, weekly AFIP rounds and much of the pathology coursework offered by the Department.

Selected Publications

1. Reduction of Age-associated Pathology in Old Mice by Overexpression of Catalase in Mitochondria. Treuting PM, Linford, NJ, Knoblaugh SE, Emond MJ, Morton JF, Martin GM, Rabinovitch PS, Ladiges WC. The Journal of Gerontology: Biological Sciences, in press.
2. Rubtsov YP, Rasmussen JP, Chi EY, Fontenot J, Castelli L, Ye X, Treuting P, Siewe L, Roers A, Henderson WR Jr, Muller W, Rudensky AY. Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces. Immunity. 2008 Apr 1; [Epub ahead of print]
3. Rosenberger CM, Clark AE, Treuting PM, Johnson CD, Aderem A. ATF3 Regulates MCMV Infection in Mice by Modulating Interferon-γ Expression in Natural Killer Cells. 2007. Proc Natl Acad Sci U S A. 2008 Feb 19; 105( 7): 2544-9. Epub 2008 Feb 11.
4. Torrence AE, Brabb T, Viney JL, Bielefeldt-Ohmann H, Treuting P, Seamons A, Drivdahl R, Zeng W, Maggio-Price L. Serum biomarkers in a mouse model of bacterial-induced inflammatory bowel disease.Inflamm Bowel Dis. 2007 Dec 19; [Epub ahead of print]
5. Cross DJ, Flexman JA, Anzai Y, Sasaki T, Treuting PM, Maravilla KR, Minoshima S. In vivo manganese MR imaging of calcium influx in spontaneous rat pituitary adenoma. AJNR Am J Neuroradiol. 2007 Nov-Dec;28(10):1865-71. Epub 2007 Oct 9.
6. Venkatesan RN, Treuting PM, Fuller ED, Goldsby RE, Norwood TH, Gooley TA, Ladiges WC, Preston BD, Loeb LA. Mutation at the polymerase active site of mouse DNA polymerase delta increases genomic instability and accelerates tumorigenesis. Mol Cell Biol. 2007 Nov;27(21):7669-82. Epub 2007 Sep 4.
7. Sather BD, Treuting P, Perdue N, Miazgowicz M, Fontenot JD, Rudensky AY, Campbell DJ. Altering the distribution of Foxp3(+) regulatory T cells results in tissue-specific inflammatory disease. J Exp Med. 2007 Jun 11;204(6):1335-47. Epub 2007 Jun 4.
8. Bollen AM, Baskin CR, Treuting PM. Urolithiasis in rats consuming a dl bitartrate form of choline in a purified diet. Comp Med. 2006 Aug;56(4):245.
9. Maggio-Price L, Treuting P, Zeng W, Tsang M, Bielefeldt-Ohmann H, Iritani BM. Helicobacter infection is required for inflammation and colon cancer in SMAD3-deficient mice. Cancer Res. 2006 Jan 15;66(2):828-38.
10. Maggio-Price L, Bielefeldt-Ohmann H, Treuting P, Iritani BM, Zeng W, Nicks A, Tsang M, Shows D, Morrissey P, Viney JL. Dual infection with Helicobacter bilis and Helicobacter hepaticus in p-glycoprotein-deficient mdr1a-/- mice results in colitis that progresses to dysplasia. Am J Pathol. 2005 Jun;166(6):1793-806.
11. Schriner SE, Linford NJ , Martin GM, Treuting P, Ogburn CE, Emond M, Coskun PE , Ladiges W, Wolf N, Van Remmen H, Wallace DC, Rabinovitch PS. Extension of murine life span by overexpression of catalase targeted to mitochondria. Science. 2005 Jun 24;308(5730):1909-11. Epub 2005 May 5.
12. Hukkanen RR, Richardson M, Wingfield JC, Treuting P, Brabb T. Avipox sp. in a colony of gray-crowned rosy finches (Leucosticte tephrocotis). Comp Med. 2003 Oct;53(5):548-52.
13. Treuting PM, Chen LI, Buetow BS, Zeng W, Birkebak TA, Seewaldt VL, Sommer KM, Emond M, Maggio-Price L, Swisshelm K. Retinoic acid receptor beta2 inhibition of metastasis in mouse mammary gland xenografts. Breast Cancer Res Treat. 2002 Mar;72(1):79-88.
14. Treuting PM, Hopkins HC, Ware CA , Rabinovitch PR, Ladiges WC. Generation of genetically altered mouse models for aging studies. Exp Mol Pathol. 2002 Feb;72(1):49-55.