C MED 407
The Basic Biology of the Mouse - Its Application in Model Development and Translational Research
The goal of this class is to introduce students to methods of experimental design and appropriate use of mice in biomedical research with a focus on translational research. This will be accomplished using a format of lectures and problem-based learning exercises taught by a team of scientists from both academia and industry with expertise in a variety of disciplines.
The following topics will be explored:
- History and future of mice in biomedical research.
- Biology of the mouse
- Reproduction and basic genetics
- Influence of background strain
- Biological features of mice that facilitate and influence their use as biomedical tools compared to higher species (humans)
- Endogenous and exogenous factors that compromise the use of mice as biomedical tools
- Clinical behavior
- Ethical and regulatory issues
- Writing an animal use protocol
- Basic statistics: calculating sample size, power, choosing appropriate tests
- Creating a budget for a mouse study
- Clinical procedures and husbandry
- Translational research
- Development and characterization of mouse models of human diseases.
- Construction and use of genetically manipulated mouse models.
- Behavioral testing
- Design and interpretation of toxicological studies
- Using mice in drug development
- Infectious disease models
- Expectations of the FDA