|
|||
| CMED 407: The Basic Biology of the Mouse – Its Application in Model Development and Translational Research |
The goal of this class is to introduce students to methods of experimental design and appropriate use of mice in biomedical research with a focus on translational research. This will be accomplished using a format of lectures and problem-based learning exercises taught by a team of scientists from both academia and industry with expertise in a variety of disciplines.
The following topics will be explored:
- History and future of mice in biomedical research.
- Biology of the mouse
- Nomenclature
- Reproduction and basic genetics
- Influence of background strain
- Biological features of mice that facilitate and influence their use as biomedical tools compared to higher species (humans)
- Endogenous and exogenous factors that compromise the use of mice as biomedical tools
- Clinical behavior
- Ethical and regulatory issues
- Writing an animal use protocol
- Basic statistics: calculating sample size, power, choosing appropriate tests
- Creating a budget for a mouse study
- Clinical procedures and husbandry
- Translational research
- Development and characterization of mouse models of human diseases.
- Construction and use of genetically manipulated mouse models.
- Behavioral testing
- Design and interpretation of toxicological studies
- Using mice in drug development
- Infectious disease models
- Expectations of the FDA
"All classes during Winter 2006 (Thursdays) will be held from 1:30-4:20pm in Room T-149, HSB, except January 12 which will be held at South
Campus Center Portage Bay Room."