CI2Daggett Research Group | Research | SNPs

University of Washington - College of Engineering - School of Medicine - Department of Bioengineering

Selected Projects

a-Tocopherol Transfer Protein
Catechol O-methyltransferase
Histamine N-methyltransferase
Thiopurine S-methyltransferase
Protein Isoaspartate O-methyltransferase
Parkinson disease protein DJ-1
Transthyretin
Lysozyme C
8-oxoguanine DNA glycosylase
Carbonic anhydrase
Cystatin B
Triosephosphate isomerase

Single Nucleotide Polymorphisms

COMT polymorphisms

Primary sequence variants can have severe effects on protein stability and activity. However, polymorphic proteins are not always amenable to structural study due to increased degradation rates and aggregation. 3.1 million polymorphisms have been genotyped to date, many of which are strongly associated with disease. We use molecular dynamics simulations to study the structural and dynamic effects of these polymorphisms at atomic resolution. We are currently looking at common human disease-related polymorphisms within protein-fold families to identify polymorphic hotspots and common dynamic and structural features of these variants.

Relevant Publications