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Directory >> Michael Boeckh, MD

Faculty

Contact Information

Michael Boeckh, MD

  • Professor of Medicine, University of Washington

  • Member, Vaccine and Infectious Disease & Clinical Research Divisions
    Fred Hutchinson Cancer Research Center

Dr. Boeckh heads clinical research program in transplant infectious diseases. He conducts laboratory research, observational studies as well as clinical trials of all phases.

His major areas of interest are CMV, respiratory viruses, and the genetic basis of infectious diseases. Most of these projects are bench-to-clinic translational research. Dr. Boeckh's lab is focused on pathogen-specific immune reconstitution. One major area of research is CMV, including the immune reconstitution after transplantation, transmission of CMV, and disease management in the immunocompromised patient population. Recently, he also initiated studies to determine the role of CMV reactivation in the outcome of immunocompetent patients with sepsis and acute lung injury.

Another active area of research is in respiratory viruses in immunocompromised patients. Studies are focused on the association of respiratory viruses and airflow obstruction, the adaptive immune response to respiratory viruses, viral dissemination and gene expression signatures as biomarkers for disease severity, and management strategies.

Genetic studies utilize both candidate gene and genome wide approaches to examine the genetic basis of infectious complications in transplant recipients. Studies capitalize on a unique sample repository for thousands of patients that is linked to a highly comprehensive phenotype database.


Selected Publications


Pergam SA, Xie H, Sandhu R, Pollack M, Smith J, Stevens-Ayers T, Ilieva V, Kimball LE, Huang ML, Hayes TS, Corey L, Boeckh MJ. Efficiency and risk factors for CMV transmission in seronegative hematopoietic stem cell recipients. Biol Blood Marrow Transplant. 2012; 18(9): 1391-400.
PubMed Abstract


Guerrero A, Riddell SR, Storek J, Stevens-Ayers T, Storer B, Zaia JA, Forman S, Negrin RS, Chauncey T, Bensinger W, Boeckh M. Cytomegalovirus viral load and virus-specific immune reconstitution after peripheral blood stem cell versus bone marrow transplantation. Biol Blood Marrow Transplant. 2012; 18(1): 66-75.
PubMed Abstract


Marty FM, Ljungman P, Papanicolaou G, Winston D, Chemaly R, Strasfeld L, Young J, Rodriguez T, Maertens J, Schmitt M, Einsele H, Ferrant A, Lipton JH, Villano SA, Chen H, Boeckh M for the Maribavir 1263-300 Clinical Study Group. Maribavir prophylaxis for prevention of cytomegalovirus disease in recipients of allogeneic stem-cell transplants: a phase 3, double-blind, placebo-controlled, randomised trial. Lancet Infect Dis. 2011; 11(4): 284-92.
PubMed Abstract


Choi SM, Boudreault AA, Xie H, Englund JA, Corey L, Boeckh M. Differences in clinical outcomes following 2009 influenza A/H1N1 and seasonal influenza among hematopoietic cell transplant recipients. Blood. 2011; 117(19): 5050-6.
PubMed Abstract


Boeckh M, Geballe A. Cytomegalovirus: pathogen, paradigm and puzzle.J Clin Invest. 2011; 121(5): 1673-80.
PubMed Abstract


Campbell AP, Chien JW, Kuypers J, Englund JA, Wald A, Guthrie KA, Corey L, Boeckh M. Respiratory virus pneumonia after hematopoietic cell transplantation (HCT): associations between viral load in bronchoalveolar lavage samples, viral RNA detection in serum samples, and clinical outcomes of HCT. J Infect Dis. 2010; 201(9): 1404-13.
PubMed Abstract


Milano F, Campbell AP, Guthrie KA, Kuypers J, Englund JA, Corey L, Boeckh M. Human rhinovirus and coronavirus detection among allogeneic hematopoietic stem cell transplantation recipients. Blood. 2010; 115(10): 2088-94. Epub 2009 Dec 30.
PubMed Abstract


Bochud PY, Chien WJ, Marr K, Leisenring WM, Upton A, Janer M, Rodrigues SD, Li S, Aderem A, Boeckh M. Toll-like receptor 4 polymorphisms and aspergillosis in stem-cell transplantation. New Engl J Med. 2008; 359(17): 1766-77.
PubMed Abstract


Limaye AP, Kirby KA, Rubenfeld GD, Leisenring WM, Bulger EM, Neff MJ, Gibran NS, Huang ML, Santo TK, Corey L, Boeckh M. Cytomegalovirus reactivation in critically ill immunocompetent patients. JAMA. 2008; 300(4): 413-22.
PubMed Abstract

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