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Directory >> Michael Boeckh, MD

Faculty

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Michael Boeckh, MD

  • Professor of Medicine, University of Washington
  • Member, Vaccine and Infectious Disease & Clinical Research Divisions
  • Fred Hutchinson Cancer Research Center
  • Head, Infectious Disease Sciences Program
  • Vaccine and Infectious Disease Division
  • Head, Infectious Disease Consulting Service
  • Seattle Cancer Care Alliance
  • Attending Physician
  • Seattle Cancer Care Alliance

Dr. Boeckh heads a clinical research program focused on infectious diseases in immunocompromised patients. He conducts laboratory research, observational studies, as well as clinical trials of all phases.

His major areas of interest are cytomegalovirus (CMV), HHV-6 respiratory viruses, and the genetic basis of infectious diseases. Most of these projects are bench-to-clinic translational research. Dr. Boeckh's lab is focused on pathogen-specific immune reconstitution. One major area of research is CMV, including the immune reconstitution after transplantation, transmission of CMV, and disease management in the immunocompromised patient population. Recently, he also initiated studies to determine the role of CMV and HHV-6 reactivation in the outcome of immunocompetent patients with sepsis and acute lung injury.

Another active area of research is in respiratory viruses. Studies in immunocompromised patients are focused on the association of respiratory viruses and airflow obstruction, the adaptive immune response to respiratory viruses, viral dissemination and gene expression signatures as biomarkers for disease severity, and management strategies. Recently, he's initiated studies to examine viral dynamics in immunocompetent patients.

Another interest is to study the impact of the microbiome on post-transplant infections and adaptive immunity.


Selected Publications

Seo S, Xie H, Campbell AP, Kuypers JM, Leisenring WM, Englund JA, Boeckh MJ. Parainfluenza virus lower respiratory tract disease after hematopoietic cell transplantation: viral detection in the lung predicts outcome. Clin Infect Dis. May 2014; 58(10):1357-68
PubMed Abstract


Waghmare A, Campbell AP, Xie H, Seo S, Kuypers J, Leisenring W, Jerome KR, Englund JA, Boeckh MJ. Respiratory syncytial virus lower respiratory disease in hematopoietic cell transplant recipients: viral RNA detection in blood, antiviral treatment, and clinical outcomes.  Clin Infect Dis . December 2013; 57(12):1731-41.
PubMed Abstract


Marty FM, Winston DJ, Rowley SD, Vance E, Papanicolaou GA, Mullane KM, Brundage TM, Robertson AT, Godkin S, Momméja-Marin H, Boeckh MJ. CMX001-201 Clinical Study Group. CMX001 to Prevent Cytomegalovirus in Hematopoietic-Cell Transplantation.  N Engl J Med. September 2013; 369(13):1227-36.
PubMed Abstract


Green ML, Leisenring WM, Xie H, Walter RB, Mielcarek M, Sandmaier BM, Riddell SR, Boeckh MJ CMV reactivation after allogeneic HCT and relapse risk: evidence for early protection in acute myeloid leukemia.  Blood. August 2013; 122(7):1316-24.
PubMed Abstract


Guerrero A, Riddell SR, Storek J, Stevens-Ayers T, Storer B, Zaia JA, Forman S, Negrin RS, Chauncey T, Bensinger W, Boeckh M. Cytomegalovirus viral load and virus-specific immune reconstitution after peripheral blood stem cell versus bone marrow transplantation. Biol Blood Marrow Transplant. 2012; 18(1):66-75.
PubMed Abstract


Marty FM, Ljungman P, Papanicolaou G, Winston D, Chemaly R, Strasfeld L, Young J, Rodriguez T, Maertens J, Schmitt M, Einsele H, Ferrant A, Lipton JH, Villano SA, Chen H, Boeckh M for the Maribavir 1263-300 Clinical Study Group. Maribavir prophylaxis for prevention of cytomegalovirus disease in recipients of allogeneic stem-cell transplants: a phase 3, double-blind, placebo-controlled, randomised trial. Lancet Infect Dis. 2011; 11(4):284-92.
PubMed Abstract


Boeckh M, Geballe A. Cytomegalovirus: pathogen, paradigm and puzzle. J Clin Invest. 2011; 121(5):1673-80.
PubMed Abstract


Bochud PY, Chien WJ, Marr K, Leisenring WM, Upton A, Janer M, Rodrigues SD, Li S, Aderem A, Boeckh M. Toll-like receptor 4 polymorphisms and aspergillosis in stem-cell transplantation. New Engl J Med. 2008; 359(17):1766-77.
PubMed Abstract


Limaye AP, Kirby KA, Rubenfeld GD, Leisenring WM, Bulger EM, Neff MJ, Gibran NS, Huang ML, Santo TK, Corey L, Boeckh M. Cytomegalovirus reactivation in critically ill immunocompetent patients. JAMA. 2008; 300(4):413-22.
PubMed Abstract

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