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Directory >> Karol Bomsztyk, MD


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Karol Bomsztyk, MD

  • Professor of Medicine and Adjunct Professor of Pharmacology
    University of Washington

Detrimental epigenetic processes are emerging as major pathophysiologic culprits of disease including inflammation, infection and organ injury. These processes involve signaling, transcription and epigenetic factors that regulate gene transcription in the chromatin environment, or the epigenome. To better define epigenetic processes in health and disease, our laboratory has been developing high throughput and sensitivity epigenetic platforms and computational tools and have applied them to study acute organ injury, including sepsis. Using these methods and computational tools we have also began series of studies to better understand epigenetic bases of HIV latency.

Current research projects available to trainees include epigenetic studies of inflammation as well as multiple organ injury in experimental sepsis, epigenetic bases of HIV latency, development of high throughput and sensitivity epigenetic methods, development of urine and blood epigenetic biomarkers, development of computational tools to acquire, analyze and visualize epigenetic data.

Research funding: NIH, Life Sciences Discovery Fund (LSDF) of Washington and The Foundation for AIDS Research (amfAR).

Dr. Bomsztyk research area interests:

  • Development of high throughput sample preparation and epigenetics analytical platforms.
  • Epigenetics of acute organ injury, inflammation and infection
  • Epigenetics of HIV latency.

  • Selected Publications

    Heterogeneity of epigenetic changes at ischemia/reperfusion- and endotoxin-induced acute kidney injury genes. Mar,D., Gharib,S.A., Zager,R.A., Johnson,A., Denisenko,O., Bomsztyk,K.  Kidney Int. 2015 (in press).

    Experimental acute lung injury induces multi-organ epigenetic modifications in key angiogenic genes implicated in sepsis-associated endothelial dysfunction. Bomsztyk K, Mar D, An D, Sharifian R, Mikula M, Gharib SA, Altemeier WA, Liles WC, Denisenko O. Crit Care. 2015 May 11;19(1):225. PMID:25959381
    PubMed Abstract

    Losartan reverses permissive epigenetic changes in renal glomeruli of diabetic db/db mice. Reddy MA, Sumanth P, Lanting L, Yuan H, Wang M, Mar D, Alpers CE, Bomsztyk K, Natarajan R. Kidney Int. 2014 Feb;85(2):362-73. PMID: 24088954
    PubMed Abstract

    Synchronous recruitment of epigenetic modifiers to endotoxin synergistically activated Tnf-α gene in acute kidney injury. Bomsztyk K, Flanagin S, Mar D, Mikula M, Johnson A, Zager R, Denisenko O. PLoS One. 2013 Jul 30;8(7):e70322. PMID: 23936185
    PubMed Abstract

    Epigenetic changes in renal genes dysregulated in mouse and rat models of type 1 diabetes. Komers R, Mar D, Denisenko O, Xu B, Oyama TT, Bomsztyk K. Lab Invest. 2013 May;93(5):543-52. PMID: 23508046
    PubMed Abstract

    Yu J, Feng Q, Ruan Y, Komers R, Kiviat N, Bomsztyk K. Microplate-based platform for combined chromatin and DNA methylation immunoprecipitation assays. BMC Mol Biol. 2011; 12: 49.
    PMID: 22098709 PMCID: PMC3247195.
    PubMed Abstract



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