AID Logo

Directory >> Connie Celum, MD, MPH

Faculty

Contact Information

Connie Celum, MD, MPH

  • Professor, Departments of Medicine and Global Health
  • Director, International Clinical Research Center, Department of Global Health
  • Adjunct Professor, Department of Epidemiology
    University of Washington

Dr. Celum's research focuses on clinical trials of biomedical HIV prevention with the objective to find effective strategies to reduce HIV acquisition and transmission, and to conduct implementation science of evidence-based strategies for HIV prevention and treatment with a focus on subSaharan Africa.

Dr. Celum was the Principal Investigator of a phase 3 randomized, placebo-controlled trial of pre-exposure antiretroviral prophylaxis, of oral tenofovir and Truvada for prevention of HIV acquisition in serodiscordant couples in Kenya and Uganda (Partners PrEP Study). She is the PI of several studies of PrEP implementation in HIV serodiscordant couples and young women. Dr. Celum is PI of a NIH grant on combination HIV prevention strategies for the heterosexual HIV epidemic in Africa. Dr. Celum's recently completed international, multi-center HIV prevention trials include genital herpes suppression for prevention of HIV acquisition among heterosexual women in Africa and men who have sex with men in the Americas (HPTN 039) and among HIV infected persons in African serodiscordant couples to reduce HIV transmission and disease progression (Partners in Prevention).

Dr. Celum is the Principal Investigator of a phase 3 randomized, placebo-controlled trial of pre-exposure antiretroviral prophylaxis, of oral tenofovir and Truvada for prevention of HIV acquisition in serodiscordant couples in Kenya and Uganda. She is a co-investigator in the NIH-funded Microbicides Trials Network. Dr. Celum is PI of a NIH grant on combination HIV prevention strategies for the heterosexual HIV epidemic in Africa. Most of her research is conducted through international collaborations, including with colleagues and sites in South Africa, Kenya, and Uganda. She has many collaborators; among them, Drs. McElrath, Marrazzo, Corey, Wald, Lingappa, Baeten and Holmes.


Selected Publications


Celum C, Morrow R, Donnell D, Hong T, Hendrix CW, Thomas K, Fife K, Nakku-Joloba E, Mujugira A, Baeten JM; Partners PrEP Study Team.  Daily oral tenofovir and emtricitabine-tenofovir preexposure prophylaxis reduces herpes simplex virus type 2 acquisition among heterosexual HIV-1-uninfected men and women:  a subgroup analysis of a randomized trial. Ann Intern Med.  2014; 161:11-9
PubMed Abstract

Barnabas RV, van Rooyen H, Tumwesigye E, Murnane PM, Baeten JM, Humphries H, Turyamureeba B, Joseph P, Krows M, Hughes JP, Celum C. Initiation of antiretroviral therapy and viral suppression after home HIV testing and counselling in KwaZulu-Natal, South Africa, and Mbarara district, Uganda: a prospective, observational intervention study. Lancet HIV. 2014; 1:e68-e76. PMCID:  4292844
PubMed Abstract

Baeten JM, Donnell D, Ndase P, Mugo NR, Campbell JD, Wangisi J, Tappero JW, Bukusi EA, Cohen CR, Katabira E, Ronald A, Tumwesigye E, Were E, Fife KH, Kiarie J, Farquhar C, John-Stewart G, Kakia A, Odoyo J, Mucunguzi A, Nakku-Joloba E, Twesigye R, Ngure K, Apaka C, Tamooh H, Gabona F, Mujugira A, Panteleeff D, Thomas KK, Kidoguchi L, Krows M, Revall J, Morrison S, Haugen H, Emmanuel-Ogier M, Ondrejcek L, Coombs RW, Frenkel L, Hendrix C, Bumpus NN, Bangsberg D, Haberer JE, Stevens WS, Lingappa JR, Celum C for the Partners PrEP Study Team. Antiretroviral prophylaxis for HIV-1 prevention among heterosexual men and women. N Engl J Med. 2012; 367(5): 399-410.
PubMed Abstract

Donnell D, Baeten JM, Kiarie J, Thomas KK, Stevens W, Cohen CR, McIntyre J, Lingappa JR, Celum C; Partners in Prevention HSV/HIV Transmission Study Team. Heterosexual HIV-1 transmission after initiation of antiretroviral therapy: a prospective cohort analysis. Lancet. 2010; 375(9731): 2092-8.
PMID: 20537376
PubMed Abstract

Celum C, Wald A, Lingappa JR, et al for the Partners in Prevention HSV/HIV Transmission Study Team. Acyclovir and transmission of HIV-1 from persons infected with HIV-1 and HSV-2. N Engl J Med. 2010; 362: 427-39.
PMCID: 2838503
PubMed Abstract

Celum C, Wald A, Hughes J, et al. Effect of aciclovir on HIV-1 acquisition in herpes simplex virus 2 seropositive women and men who have sex with men: a randomised, double-blind, placebo-controlled trial. Lancet. 2008; 371(9630): 2109-2119.
PubMed Abstract

to top