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Directory >> Arturo Centurion, MD

Faculty

Centurion

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Arturo Centurion, MD

  • Research Associate Professor Emeritus
  • University of Washington
  • Research Professor
  • Universidad Peruana Cayetano Heredia, Peru

Dr. Centurion's research focuses on Treponema pallidum, the etiologic agent of syphilis.

  1. Pathoadaptive mutations
    In collaboration with Dr. Evgeni Sokurenko, we are studying the genome-wide genetic diversity within T. pallidum species and subspecies. These studies use population genomics by analyzing gene presence/absence and single nucleotide polymorphisms across genomes of different strains. The primary goal of is to identify adaptive mutations that facilitate bacterial survival in specific habitats and, in particular, sequence changes associated with different clinical outcomes in humans and the animal model
  2. Congenital syphilis
    Research interest is directed at understanding patterns of antibody responses in pregnant women and newborns during syphilis infection. Specifically, we are interested in antibody responses to T. pallidum antigens in pregnant women as predictors of effective treatment, and immunoproteome profiles in mothers and newborns associated with particular clinical outcomes

Selected Publications


Centurion-Lara A, Castro C, Barrett LK, Cameron C, Mostowfi M, Van Voorhis WC, Lukehart SA. Treponema pallidum major sheath protein homologue Tpr K is a target of opsonic antibody and the protective immune response. J Exp Med. 1999; 189: 647-56.
JEM Abstract


Centurion-Lara A, LaFond RE, Hevner K, Godornes C, Molini BJ, Van Voorhis WC, Lukehart SA. Gene conversion: a mechanism for generation of heterogeneity in the tprK gene of Treponema pallidum during infection. Mol Microbiol. 2004; 52(6): 1579-96.
PubMed Abstract


Giacani L, Lukehart SA, Centurion-Lara A. Length of guanosine homopolymeric repeats modulates promoter activity of Subfamily II tpr genes of Treponema pallidum ssp. pallidum. FEMS Immunol Med Microbiol. 2007; 51(2): 289-301.
PubMed Abstract


Giacani L, Godornes C, Puray-Chavez M, Guerra-Giraldez C, Tompa M, Lukehart SA, Centurion-Lara A. TP0262 is a modulator of promoter activity of tpr Subfamily II genes of Treponema pallidum ssp. pallidum. Mol Microbiol. 2009; 72(5): 1087-99.
PubMed Abstract

Centurion-Lara A, Giacani L, Godornes C, Molini BJ, Brinck Reid T, Lukehart SA. Fine analysis of genetic diversity of the tpr gene family among treponemal species, subspecies and strains. PLoS Negl Trop Dis. 2013 16;7(5):e2222.
PubMed Abstract

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