UW Medicine Division of Allergy and Infectious Diseases
Directory >> Lawrence Corey, MD

Faculty

Lawrence Corey, MD

  • President and Director, Fred Hutchinson Cancer Research Center
  • Member, Fred Hutchinson Cancer Research Center Vaccine and Infectious Disease Division, Clinical Research Division and Public Health Sciences Division
  • Professor, Medicine and Laboratory Medicine, University of Washington
  • Adjunct Professor, Departments of Pediatrics and Microbiology, University of Washington

The research areas associated with Dr. Corey include

  • Herpes group infections.
  • infections in the immunocompromised host, especially those undergoing bone marrow transplant.
  • HIV vaccine development.

The herpes virus research program at the University of Washington involves studies in HSV, CMV, HHV-6 and HHV-8. The genital HSV program has been the most longstanding, having had continuous NIH funding since 1978. This program involves clinical investigations of HSV reactivation and transmission, laboratory based studies on the cellular immunology of HSV, and characterization of HSV-HIV interactions. In the last few years, the laboratory has focused on developing an HSV vaccine by defining the T-cell responses to HSV, especially cytotoxic T-cell responses as a means of developing CTL-based vaccines for immunotherapy or prophylaxis of genital HSV. The laboratory based programs involve collaborations with Drs. Jia Zhu, Research Assistant Professor; David Koelle, Professor of Medicine; Keith Jerome, Professor of Laboratory Medicine, University of Washington and now Head of the Diagnostic Virology Division; and Christine Posavad, Senior Scientist at the Hutchinson Center. The Clinical Research Program in genital herpes is directed by Dr. Anna Wald, Professor of Medicine, University of Washington and Dr. Christine Johnston, Assistant Professor of Medicine, University of Washington. Dr. Wald is medical director of the Viral Disease Clinic, a specialty clinic dedicated to a wide range of clinical studies on HSV infection, including resolution frequency, vaccine efficacy and technology development.

The program in HHV-8 infection encompasses studies of the transmission of HHV-8 and the mechanism by which HHV-8 induces Kaposi's sarcoma. This work is done with Dr. Corey Casper, Associate Member at the Hutchinson Center. Clinical trials for HHV-8 prevention are conducted in the newly formed Uganda Program on Cancer and Infectious Diseases under the direction of Dr. Orem Jackson of the Uganda Cancer Institute and Dr. Corey Casper and Dr. Warren Phipps at the Hutchinson Center.

The Vaccine and Infectious Disease Division (VIDD) of the Hutchinson Center is home to many researchers studying prevention of CMV and HHV-6 infections in the immunocompromised host and the role these infections play in the morbidity of HSCT. Dr. Michael Boeckh, Professor of Medicine heads research on CMV infection in collaboration with Dr. Steven Pergam, Associate Professor in Medicine.

The HIV research program directed by Dr. Corey includes both laboratory and clinical investigation. Dr. Corey is the PI of the NIAID supported HIV Vaccine Trials Network (HVTN), a global network of clinical trial sites and laboratories dedicated to phase I-III trials of candidate HIV vaccines and other preventative and treatment options. Other faculty members involved in the effort are Drs. Juliana McElrath, Peter Gilbert and Jim Kublin. Training opportunities for postdoctoral fellows interested in learning vaccine biology and clinical trial research are available within the network.

Selected Publications

Gray GE, Allen M, Moodie Z, Churchyard G, Bekker, L-G, Nchabeleng M, Mlisana K, Metch B, de Bruyn G, Latka MH, Roux S, Mathebula M, Naicker N, Ducar C, Carter DK, Puren A, Eaton N, McElrath MJ, Robertson M, Corey L, Kublin JG, on behalf of the HVTN 503/Phambili study team. . Safety and efficacy of the HVTN 503/Phambili Study of a clade-B-based HIV-1 vaccine in South Africa: a double-blind, randomized, placebo-controlled test-of-concept phase 2b study. Lancet Infect Dis. 2011;11:507-515.
[The following link will open in a new window. PubMed Abstract ]

Schiffer JT, Abu-Raddad L, Mark KE, Zhu J, Selke S, Koelle DM, Wald A, Corey L. Mucosal host immune response predicts the severity and duration of herpes simplex virus-2 genital tract shedding episodes. Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):18973-8. PMC2973882
[ The following link will open in a new window. PubMed Abstract ]

Zhu J, Hladik F, Woodward A, Klock A, Peng T, Johnston C, Remington M, Magaret A, Koelle DM, Wald A, Corey L. Persistence of HIV-1 Receptor-Positive Cells after HSV-2 Reactivation: A Potential Mechanism for Increased HIV-1 Acquisition. Nat Med. 2009 Aug;15(8):886-92.
[The following link will open in a new window. PubMed Abstract ]

Zhu J, Koelle DM, Cao J, Vazquez J, Huang ML, Hladik F, Wald A, Corey L. Virus-specific CD8+ T cells accumulate near sensory nerve endings in genital skin during subclinical HSV-2 reactivation. J Exp Med. 2007 Mar 19;204(3):595-603.
[ The following link will open in a new window. PubMed Abstract ]

Mark KE, Wald A, Magaret AS, Selke S, Olin L, Huang ML, Corey L. Rapidly cleared episodes of herpes simplex virus reactivation in immunocompetent adults. J Infect Dis 2008; 198:1141-1149.
[The following link will open in a new window. PubMed Abstract ]

Rolland M, Tovanabutra S, Decamp AC, Frahm N, Gilbert PB, Sanders-Buell E, Heath L, Magaret CA, Bose M, Bradfield A, O'Sullivan A, Crossler J, Jones T, Nau M, Wong K, Zhao H, Raugi DN, Sorensen S, Stoddard JN, Maust BS, Deng W, Hural J, Dubey S, Michael NL, Shiver J, Corey L, Li F, Self SG, Kim J, Buchbinder S, Casimiro DR, Robertson MN, Duerr A, McElrath MJ, McCutchan FE, Mullins JI.Genetic impact of vaccination on breakthrough HIV-1 sequences from the STEP trial. Nat Med. 2011 Mar;17(3):366-71. PMC3053571
[The following link will open in a new window. PubMed Abstract ]

 

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