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Directory >> Lawrence Corey, MD

Faculty

Contact Information

Lawrence Corey, MD

  • Member
    Divisions of Vaccine and Infectious Disease, Clinical Research, and Public Health Sciences
    President and Director Emeritus
    Fred Hutchinson Cancer Research Center
  • Professor, Departments of Medicine and Laboratory Medicine
  • Adjunct Professor, Departments of Pediatrics and Microbiology
    University of Washington

The research areas associated with Dr. Corey include:

  • Herpes simplex virus type 2 (HSV-2) pathogenesis and the host immune response
  • Immunotherapeutic approaches to viral infections and cancer
  • HIV and herpesvirus vaccine development

My laboratory currently focuses on the immunobiology of HSV-2 infections. I've had a longstanding interest in this area, having had continuous NIH funding since 1978. This program involves clinical investigations of HSV reactivation and transmission, laboratory based studies on the cellular immunology of HSV, and characterization of HSV-HIV interactions. In the last few years, the laboratory has focused on developing an HSV vaccine by defining the T-cell responses to HSV, especially cytotoxic T-cell responses as a means of developing CTL-based vaccines for immunotherapy or prophylaxis of genital HSV. The laboratory has focused on tissue resident T cells and uses a number of recently developed technologies to investigate in situ immune responses to HSV reactivation. These technologies are also adapted to studies of HIV cure. Drs. Jia Zhu, research assistant professor; David Koelle, professor of Medicine; Keith Jerome, professor of Laboratory Medicine and head of the Diagnostic Virology Division; and Christine Posavad, senior principal research scientist are involved in the laboratory programs. The Clinical Research Program in genital herpes is directed by Dr. Anna Wald, professor of Medicine and Dr. Christine Johnston , assistant professor of Medicine. Dr. Wald is medical director of the Viral Disease Clinic, a specialty clinic dedicated to a wide range of clinical studies on HSV infection, including resolution frequency, vaccine efficacy and technology development.

Most recently, the laboratory has been involved with defining the mechanisms by which chimeric antigen receptor T cells (CAR T cells) kill tumor and HIV targets in vivo. These studies are done in collaboration with investigators in tumor immunity and transplant biology at the Fred Hutch.

Dr. Corey is co-PI of the NIAID supported HIV Vaccine Trials Network (HVTN), a global network of clinical trial sites and laboratories dedicated to phase I-III trials of candidate HIV vaccines and other preventative and treatment options. Candidates interested in developing a career in HIV vaccines are available for mentorship by Dr. Corey.

Training opportunities for postdoctoral fellows interested in learning vaccine biology and clinical trial research are available.

Selected Publications


Zhu J, Koelle DM, Cao J, Vazquez J, Huang ML, Hladik F, Wald A,Corey L. Virus-specific CD8+ T cells accumulate near sensory nerve endings in genital skin during subclinical HSV-2 reactivation. J Exp Med. 2007; 204(3): 595-603.
PubMed Abstract

Zhu J, Peng T, Johnston C, Phasouk K, Kask AS, Klock A, Jin L, Diem K, Koelle DM, Wald A, Robins H,Corey L. Immune surveillance by CD8aa+ skin-resident T cells in human herpes virus infection. Nature. 2013 May 23;497(7450):494-7. PMC3663925
PubMed Abstract

Schiffer JT, Abu-Raddad L, Mark KE, Zhu J, Selke S, Koelle DM, Wald A, Corey L. Mucosal host immune response predicts the severity and duration of herpes simplex virus-2 genital tract shedding episodes. Proc Natl Acad Sci U S A. 2010;107(44): 18973-8. PMCID: PMC2973882
PubMed Abstract

Gray GE, Allen M, Moodie Z, Churchyard G, Bekker, L-G, Nchabeleng M, Mlisana K, Metch B, de Bruyn G, Latka MH, Roux S, Mathebula M, Naicker N, Ducar C, Carter DK, Puren A, Eaton N, McElrath MJ, Robertson M, Corey L, Kublin JG, on behalf of the HVTN 503/Phambili study team. Safety and efficacy of the HVTN 503/Phambili Study of a clade-B-based HIV-1 vaccine in South Africa: a double-blind, randomized, placebo-controlled test-of-concept phase 2b study. Lancet Infect Dis. 2011; 11(7): 507-15.
PubMed Abstract

Peng T, Zhu J, Phasouk K, Koelle D, Wald A and Corey L. An effector phenotype of CD8+ T cells at the junction epithelium during clinical quiescence of HSV-2 infection. J Virol. 2012 Oct;86(19):10587-96. PMC3457322
PubMed Abstract

Christine M. Posavad, Lin Zhao, Dawn E. Mueller, Claire E. Stevens, Meei Li Huang, Anna Wald and Lawrence Corey. Persistence of mucosal T cell responses to herpes simplex virus type 2 (HSV-2) in the female genital tract. Mucosal Immun. 2015 Jan;8(1):115-26. PMC4263695 [Available on 2015/7/1]
PubMed Abstract

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