UW Medicine Division of Allergy and Infectious Diseases
Directory >> Michael Emerman, PhD

Faculty

Contact Information

Michael Emerman, PhD

  • Affiliate Professor of Microbiology
  • University of Washington
  • Member, Fred Hutchinson Cancer Research Center

This laboratory studies the regulatory and structural genes of the human immunodeficiency virus (HIV) in order to understand the molecular basis for its pathogenicity. Our focus is on identifying and characterizing host cell functions that are used to serve specific functions for viral replication and host functions that oppose viral replication. Current major projects include the study of how host antiviral genes have evolved during primate evolution, and the study of events that occur early after HIV enters its host cells. Collaborators include Harmit Malik and Julie Overbaugh.

Further information on the lab and recent publications at http://www.fhcrc.org/science/labs/emerman/.


Selected Publications


Lim ES, Fregoso OI, McCoy CO, Matsen FA, Malik HS, Emerman M. The Ability of Primate Lentiviruses to Degrade the Monocyte Restriction Factor SAMHD1 Preceded the Birth of the Viral Accessory Protein Vpx. Cell Host Microbe. 2012 Feb 16; 11(2):194-204.
[The following link will open in a new window. PubMed Abstract ]


Compton AA, Hirsch VM, Emerman M. The Host Restriction Factor APOBEC3G and Retroviral Vif Protein Coevolve due to Ongoing Genetic Conflict. Cell Host Microbe. 2012 Jan 19; 11(1):91-8.
[ The following link will open in a new window. PubMed Abstract ]


Duggal NK, Malik HS, Emerman M. The breadth of antiviral activity of Apobec3DE in chimpanzees has been driven by positive selection. J Virol. 2011 Nov; 85(21):11361-71.
[ The following link will open in a new window. PubMed Abstract ]


Li MM, Emerman M. Polymorphism in human APOBEC3H affects a phenotype dominant for subcellular localization and antiviral activity. J Virol. 2011 Aug; 85(16):8197-207.
[The following link will open in a new window. PubMed Abstract ]


Tareen SU, Emerman M. Human Trim5a has additional activities that are uncoupled from retroviral capsid recognition. Virology. 2011 Jan 5; 409(1):113-20.
[The following link will open in a new window. PubMed Abstract ]


Lim ES, Malik HS, Emerman M. Ancient adaptive evolution of tetherin shaped the functions of Vpu and Nef in human immunodeficiency virus and primate lentiviruses. J Virol. 2010 Jul; 84(14):7124-34.
[The following link will open in a new window. PubMed Abstract ]

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