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Directory >> Michael Emerman, PhD

Faculty

Contact Information

Michael Emerman, PhD

  • Affiliate Professor of Microbiology
  • University of Washington
  • Member, Fred Hutchinson Cancer Research Center

This laboratory studies the regulatory and structural genes of the human immunodeficiency virus (HIV) in order to understand the molecular basis for its pathogenicity. Our focus is on identifying and characterizing host cell functions that are used to serve specific functions for viral replication and host functions that oppose viral replication. Current major projects include the study of how host antiviral genes have evolved during primate evolution, and the study of events that occur early after HIV enters its host cells. Collaborators include Harmit Malik and Julie Overbaugh.

Further information on the lab and recent publications at http://www.fhcrc.org/science/labs/emerman/.


Selected Publications


Lim ES, Fregoso OI, McCoy CO, Matsen FA, Malik HS, Emerman M. The ability of primate lentiviruses to degrade the monocyte restriction factor SAMHD1 preceded the birth of the viral accessory protein Vpx. Cell Host Microbe. 2012; 11(2): 194-204.
PubMed Abstract


Compton AA, Hirsch VM, Emerman M. The host restriction factor APOBEC3G and retroviral Vif protein coevolve due to ongoing genetic conflict. Cell Host Microbe. 2012; 11(1): 91-8.
PubMed Abstract


Duggal NK, Malik HS, Emerman M. The breadth of antiviral activity of Apobec3DE in chimpanzees has been driven by positive selection. J Virol. 2011; 85(21): 11361-71.
PubMed Abstract


Li MM, Emerman M. Polymorphism in human APOBEC3H affects a phenotype dominant for subcellular localization and antiviral activity. J Virol. 2011; 85(16): 8197-207.
PubMed Abstract


Tareen SU, Emerman M. Human Trim5α has additional activities that are uncoupled from retroviral capsid recognition. Virology. 2011; 409(1): 113-20.
• PubMed Abstract


Lim ES, Malik HS, Emerman M. Ancient adaptive evolution of tetherin shaped the functions of Vpu and Nef in human immunodeficiency virus and primate lentiviruses. J Virol. 2010; 84(14): 7124-34.
PubMed Abstract

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