AID Logo

Directory >> Michael Emerman, PhD


Contact Information

Michael Emerman, PhD

  • Affiliate Professor of Microbiology
  • University of Washington
  • Member, Fred Hutchinson Cancer Research Center

This laboratory studies the regulatory and structural genes of the human immunodeficiency virus (HIV) in order to understand the molecular basis for its pathogenicity. Our focus is on identifying and characterizing host cell functions that are used to serve specific functions for viral replication and host functions that oppose viral replication. Current major projects include the study of how host antiviral genes have evolved during primate evolution, and the study of events that occur early after HIV enters its host cells. Collaborators include Harmit Malik and Julie Overbaugh.

Further information on the lab and recent publications at

Selected Publications

Compton, A.A., and Emerman, M. (2013) Convergence and divergence in the evolution of the APOBEC3G-Vif interaction reveal ancient origins of Simian Immunodeficiency Viruses. PLOS Pathog 9(1): e1003135. doi:10.1371
PubMed Abstract

Duggal, N. K., Fu, W., Akey, J.M. and Emerman, M. (2013) Identification and antiviral activity of common polymorphisms in the APOBEC3 locus in human populations. Virology, 443; 329-337.  br> • PubMed Abstract

Etienne, L., Hahn, B.H., Sharp, P.M., Matsen, F.A., and Emerman, M. (2013) Gene loss and adaptation to hominids underlie the ancient origin of HIV-1. Cell Host Microbe, 14, 85-92.
PubMed Abstract

Fregoso, O.I., Ahn, J., Wang, C., Mehrens, J., Skowronski, J., and Emerman, M. (2013) Evolutionary Toggling of Vpx/Vpr Specificity Results in Divergent Recognition of the Restriction Factor SAMHD1. PLOS Pathog 9(7) (8):e1001641.
PubMed Abstract

Spragg, C.J., and Emerman, M. (2013). Antagonism of SAMHD1 is actively maintained in natural infections of Simian Immunodeficiency Virus.  Proc. Natl. Acad. Sci. USA, 110, 21136-21141.
PNAS Abstract

Lim, E.S, Fregoso, O.I., McCoy, C.O., Matsen, F.A., Malik, H.S., and Emerman, M. (2012) The ability of primate lentiviruses to degrade the monocyte restriction factor SAMHD1 preceded the birth of the viral accessory protein Vpx. Cell Host Microbe. 2012 Feb 16;11(2):194-204.
PubMed Abstract

to top