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Directory >> Thomas Hawn, MD, PhD

Faculty

Contact Information

Thomas Hawn, MD, PhD

  • Professor, Division of Allergy and Infectious Diseases, Department of Medicine
    University of Washington
  • Adjunct Associate Professor, Department of Global Health
    University of Washington

 

Tom studies the functional and clinical significance of human variation in the innate immune system and its regulation of susceptibility to tuberculosis and other infections. His laboratory defines and characterizes the cellular function of genetic polymorphisms in innate immune response genes and the mechanisms of how they regulate susceptibility to human infection with an overall goal of elucidating novel therapeutic strategies.

Research Projects


Current research projects include examination of the immune response to Mycobacteria. These studies are focused on understanding why individuals are resistance to M. tuberculosis infection, what regulates the response to vaccination, and studying why some individuals get more severe forms of tuberculosis (e.g. TB meningitis). All of the projects the studies involve examination of the human immune response with a mixture of genetic and cellular techniques to compare immune responses in different populations. Cellular studies include manipulation of gene expression with gene editing techniques and the study of innate immune responses to M. tuberculosis infection in monocytes and macrophages.

 

Selected Publications


Hawn TR, Verbon A, Lettinga KD, et al. A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease. J Exp Med. 2003; 198(10): 1563-72.
PubMed Abstract

Thuong NT, Dunstan SJ, Chau TT, Thorsson V, Simmons CP, Quyen NT, Thwaites GE, Thi Ngoc Lan N, Hibberd M, Teo YY, Seielstad M, Aderem A, Farrar JJ, Hawn TR. Identification of tuberculosis susceptibility genes with human macrophage gene expression profiles. PLoS Pathog. 2008; 4(12): e1000229. PMC: 2585058
PubMed Abstract

Randhawa AK, Shey MS, Keyser A, Peixoto B, Wells RD, de Kock M, Lerumo L, Hughes J, Hussey G, Hawkridge A, Kaplan G, Hanekom WA, Hawn TR, and the SATVI team. Association of human TLR1 & TLR6 deficiency with altered immune responses to BCG vaccination in South African infants. PLoS Pathogens. 2011; 7: e1002174.
PMC:
3154845
PubMed Abstract

Shah JA, Vary JC, Chau TTH, Bang ND, Yen NTB, Farrar JJ, Dunstan SJ, Hawn TR. Human TOLLIP regulates TLR2 and TLR4 signaling and its polymorphisms are associated with susceptibility to tuberculosis.  J. Immunol.  2012; 189(4): 1737-46.
PubMed Abstract

Campo, M, Randhawa, AK, Dunstan, S, Farrar, JJ, Caws, M, Bang, ND, Lan, NN, Chau, HHT, Horne, DJ, Thuong, NT, Thwaites, GE and Hawn, TR (2014) Common polymorphisms in the CD43 gene region are associated with tuberculosis susceptibility and mortality.  Am J Respir Cell Mol Biol.  Epub ahead of print.
PubMed Abstract

Berrington, WR, Kunwar, CB, Neupane, K, van den Eeden, SJF, Vary, JC, Peterson, GJ, Wells, RW, Geluk, A, Hagge, DA, Hawn, TR. (2014)  Differential dermal expression of CCL17 and CCL18 in tuberculoid and lepromatous leprosy.  PLoS Neglected Tropical Diseases.  8(11):e3263.
PubMed Abstract

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