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Directory >> Thomas Hawn, MD, PhD

Faculty

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Thomas Hawn, MD, PhD

  • Professor, Division of Allergy and Infectious Diseases, Department of Medicine
    University of Washington
  • Adjunct Associate Professor, Department of Global Health
    University of Washington

The Hawn lab is investigating immunologic mechanisms of disease pathogenesis with an emphasis on genetic, cellular, and molecular studies of the innate immune response. These studies are directed towards understanding why individuals have different susceptibility to infections and whether these insights can lead to novel treatment and vaccine strategies. The group is using several approaches to understand this question. First, it is pursuing case-control human genetic studies to find associations of polymorphisms in innate immune response genes with disease susceptibility. Second, it is using ex vivo and in vitro immunologic, cellular and molecular assays to understand how these genes and their variants mediate a protective immune response. Finally, it is complementing these studies with in vivo infection models in mice with targeted gene deletions to elucidate mechanisms of disease pathogenesis. The Hawn lab is using these methods to study the pulmonary innate immune response to Mycobacterium tuberculosis, M. leprae, and Legionella pneumophila.


Selected Publications


Hawn TR, Verbon A, Lettinga KD, et al. A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease. J Exp Med. 2003; 198(10): 1563-72.
PubMed Abstract


Misch EA, Macdonald M, Ranjit C, Sapkota BR, Wells RD, Siddiqui MR, Kaplan G, Hawn TR. Human TLR1 deficiency is associated with impaired mycobacterial signaling and protection from leprosy reversal reaction. PLoS Negl Trop Dis. 2008; 2(5): e231. PMC: 2330092
PubMed Abstract


Thuong NT, Dunstan SJ, Chau TT, Thorsson V, Simmons CP, Quyen NT, Thwaites GE, Thi Ngoc Lan N, Hibberd M, Teo YY, Seielstad M, Aderem A, Farrar JJ, Hawn TR. Identification of tuberculosis susceptibility genes with human macrophage gene expression profiles. PLoS Pathog. 2008; 4(12): e1000229. PMC: 2585058
PubMed Abstract


Randhawa AK, Shey MS, Keyser A, Peixoto B, Wells RD, de Kock M, Lerumo L, Hughes J, Hussey G, Hawkridge A, Kaplan G, Hanekom WA, Hawn TR, and the SATVI team. Association of human TLR1 & TLR6 deficiency with altered immune responses to BCG vaccination in South African infants. PLoS Pathogens. 2011; 7: e1002174.
PMC:
3154845
PubMed Abstract


Tobin DM, Roca FJ, Oh SF, McMarland R, Vickery TW, Ray JP, Ko DC, Zou Y, Bang ND, Chau TTH,  Vary JC Jr., Hawn TR, et al. Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections. Cell. 2012; 148: 434-46.
PubMed Abstract


Horne DJ, Randhawa AK, Chau TTH, Bang ND, Yen NTB, Farrar JJ, Dunstan SJ, Hawn TR. Common polymorphisms in the PKP3-SIGIRR-TMEM16J gene region are associated with susceptibility to tuberculosis. J Infect Dis. 2012; 205: 586-94.
PubMed Abstract


Shah JA, Vary JC, Chau TTH, Bang ND, Yen NTB, Farrar JJ, Dunstan SJ, Hawn TR. Human TOLLIP regulates TLR2 and TLR4 signaling and its polymorphisms are associated with susceptibility to tuberculosis.  J. Immunol.  2012; 189(4): 1737-46.
PubMed Abstract

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