UW Medicine Division of Allergy and Infectious Diseases
Directory >> William Reed Henderson Jr., MD

Faculty

William Reed Henderson Jr., MD

  • Head, Allergy Section
    Director, Allergy & Immunology Fellowship Training Program
  • Professor of Medicine
  • University of Washington

Research in Dr. Henderson's laboratory focuses on

  • 5-Lipoxygenase products in airway inflammation,
  • remodeling in asthma chemogenomics to identify new molecular targets in pulmonary fibrosis and
  • role of progenitor cells in lung repair in mouse models of pulmonary fibrosis and asthma.

From the 5-lipoxygenase products of arachidonic acid metabolism studies, we are trying to determine the role of specific sPLA2s vs. cPLA2 and cysteinyl leukotrienes in the mediation of airway inflammation and remodeling in a mouse asthma model. Functional genomic studies (i.e., microarray and proteomic analyses) are being performed to determine the molecular mechanisms that mediate allergen-induced airway inflammation and remodeling. Research to identify new molecular targets in pulmonary fibrosis involve studies to determine the effect of novel antifibrotic agents on profibrotic gene expression in the airways in a mouse model of PF. These studies represent a focused effort using chemogenomics to identify, develop, and validate small molecule inhibitors of profibrotic gene expression (microarray and proteomic studies) as novel therapies in PF patients. Stem cells (embryonic and adult bone marrow-derived mouse and human cells) will be isolated and manipulated ex vivo in culture prior to in vivo administration in mice with fibrotic lungs. Important goals are to determine if engrafted cells proliferate and repair/regenerate damaged lung tissue. The effect of small molecule inhibitors of key signaling pathways in the airway fibrotic process will also be examined in these studies that may lead to novel therapies for patients with airway injury and fibrosis.

Selected Publications

Henderson WR Jr., Chi EY, Bollinger JG, Tien Y-t, Ye X, Castelli L, Rubtsov YP, Singer AG, Chiang GKS, Nevalainen T, Rudensky AY, Gelb MH. Importance of group X secreted phospholipase A2 in allergen-induced airway inflammation and remodeling in a mouse asthma model. J Exp Med., 2007; 204:865-77.
[The following link will open in a new window. PubMed Abstract ]

Peters-Golden M, Henderson WR Jr. Leukotrienes. N Engl J Med. 2007 Nov 1;357(18):1841-54.
[The following link will open in a new window. PubMed Abstract ]

Rubtsov YP, Rasmussen JP, Chi EY, Fontenot J, Castelli L, Ye X, Treuting P, Siewe L, Roers A, Henderson WR Jr, Muller W, Rudensky AY. Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity. 2008 Apr;28(4):546-58.
[The following link will open in a new window. PubMed Abstract ]

Gilchrist M, Henderson WR Jr, Clark AE, Simmons RM, Ye X, Smith KD, Aderem A. Activating transcription factor 3 is a negative regulator of allergic pulmonary inflammation. J Exp Med. 2008 Sep 29;205(10):2349-57.
[The following link will open in a new window. PubMed Abstract ]

Hallstrand TS, Wurfel MM, Lai Y, Ni Z, Gelb MH, Altemeier WA, Beyer RP, Aitken ML, Henderson WR. Transglutaminase 2, a novel regulator of eicosanoid production in asthma revealed by genome-wide expression profiling of distinct asthma phenotypes. PLoS One. 2010 Jan 5;5(1):e8583.
[The following link will open in a new window. PubMed Abstract ]

Gilchrist M, Henderson WR Jr, Morotti A, Johnson CD, Nachman A, Schmitz F, Smith KD, Aderem A. A key role for ATF3 in regulating mast cell survival and mediator release. Blood. 2010 Jun 10;115(23):4734-41. Epub 2010 Mar 4.
[The following link will open in a new window. PubMed Abstract ]

Henderson WR Jr, Chi EY, Ye X, Nguyen C, Tien YT, Zhou B, Borok Z, Knight DA, Kahn M. Inhibition of Wnt/beta-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis. Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14309-14. Epub 2010 Jul 21.
[The following link will open in a new window. PubMed Abstract ]

to top