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Directory >> William Reed Henderson Jr., MD


Contact Information

William Reed Henderson Jr., MD

  • Professor and Head, Allergy Section
    Director, Allergy and Immunology Fellowship Training Program
    Director, Center for Allergy and Inflammation
    Division of Allergy and Infectious Diseases, Department of Medicine
  • University of Washington

William R. Henderson, Jr., MD is Professor of Medicine at the University of Washington where he heads the Allergy Section, Center for Allergy and Inflammation, UW Medicine at South Lake Union. He is Director of the University of Washington Allergy and Immunology Fellowship Training Program and Chief of the UWMC Allergy Clinics. He has been recognized as one of Seattle's Top Doctors by Seattle and Seattle Met Magazines and one of U.S. News Top Doctors. He has authored over 125 peer-reviewed research publications in high impact journals such as The New England Journal of Medicine and The Journal of Clinical Investigation. His research has focused on the production of biochemical molecules that cause asthma and other allergic disorders with the goal to develop new therapies for these diseases. He has served as Chair of the American Board of Allergy and Immunology and on the Board of Directors of the American Academy of Allergy, Asthma and Immunology and the scientific advisory boards of ICOS Corporation and Gilead Sciences. He is an executive committee member of the Seattle Food Allergy Consortium (SeaFAC). Dr. Henderson is a member of the American Society of Clinical Investigation and the Association of American Physicians.

Current research in Dr. Henderson's laboratory focuses on identifying biomarker(s) of response to anti-IgE therapy and mechanisms of this response focusing on the role of mast cells and basophils in disease pathogenesis in asthma, chronic urticarial, and other allergic disorders. Genomic studies address whether unique organ-, biological pathway-, or disease-specific miRNA expression patterns constitute miRNA signatures that may be used as diagnostic or prognostic clinical tools in allergy.

Selected Publications

Henderson WR Jr, Chi EY, Bollinger JG, et al. Importance of group X secreted phospholipase A2 in allergen-induced airway inflammation and remodeling in a mouse asthma model. J Exp Med. 2007; 204: 865-77.
PubMed Abstract

Peters-Golden M, Henderson WR Jr. Leukotrienes. N Engl J Med. 2007; 357: 1841-54.
PubMed Abstract

Hallstrand TS, Wurfel MM, Lai Y, Ni Z, Gelb MH, Altemeier WA, Beyer RP, Aitken ML, Henderson WR. Transglutaminase 2, a novel regulator of eicosanoid production in asthma revealed by genome-wide expression profiling of distinct asthma phenotypes. PLoS One. 2010; 5: e8583.
PubMed Abstract

Henderson WR Jr, Chi EY, Ye X, et al. Inhibition of Wnt/β-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis. Proc Natl Acad Sci U S A. 2010; 107: 14309-14.
PubMed Abstract

Banerjee ER, Laflamme MA, Papayannopoulou T, Kahn M, Murry CE, Henderson WR Jr. Human embryonic stem cells differentiated to lung lineage-specific cells ameliorate pulmonary fibrosis in a xenograft transplant mouse model. PLoS One. 2012; 7: e33165.
doi: 10.1371/journal.pone.0033165. PMID: 22470441
PubMed Abstract

Henderson WR Jr, Ye X, Lai Y,et al. Key role of group V secreted phospholipase A2 in Th2 cytokine and dendritic cell-driven airway hyperresponsiveness and remodeling. PLoS One. 2013; 8: e56172. doi: 10.1371/journal.pone.0056172. PMID: 23451035
PubMed Abstract

Lai Y, Altemeier WA, Vandree J, Piliponsky AM, Johnson B, Appel CL, Frevert CW, Hyde DM, Ziegler SF, Smith DE, Henderson WR Jr, Gelb MH, Hallstrand TS. Increased density of intraepithelial mast cells in exercise-induced bronchoconstriction regulated via epithelial-derived TSLP and IL-33. J Allergy Clin Immunol. 2013 Nov 9. pii: S0091-6749(13)01473-5. doi: 10.1016/j.jaci.2013.08.052. [Epub ahead of print] PMID: 24220317
PubMed Abstract

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