UW Medicine Division of Allergy and Infectious Diseases
Directory >> Tobias Hohl, MD, PhD

Faculty

Contact Information

Tobias Hohl, MD, PhD

  • Assistant Professor of Medicine, University of Washington
  • Assistant Member, Clinical Research Division, Fred Hutchinson Cancer Research Center
  • Adjunct Assistant Professor, Department of Microbiology, University of Washington
  • Assistant Member, Molecular & Cellular Biology Program, University of Washington

Our laboratory research focuses on the host-pathogen relationship between medically relevant fungi and the vertebrate immune systems. Invasive aspergillosis is the most common invasive mold infection worldwide and represents a major cause of infectious morbidity and mortality in patients that receive treatment for leukemia or that undergo bone marrow transplantation. Our goal is to develop a detailed mechanistic understanding of molecular and cellular host defenses against Aspergillus fumigatus, the most common etiologic agent of invasive aspergillosis to develop novel therapeutic strategies to augment or supplement current antifungal drugs. To this end, we use a murine model of infection and rely on a combination of cell biological, immunological, and imaging techniques to probe the host-pathogen interface.

Our clinical research focuses on the performance of surrogate antigen and nucleic acid-based diagnostic tests to identify invasive aspergillosis in hematopietic stem cell transplant recipients.

Selected Publications

Cramer, R. A., Rivera, A., and T. M. Hohl.Immune responses against Aspergillus fumigatus: What have we learned? Curr. Opin. Infect. Dis. 24:315-22, 2011.
[The following link will open in a new window. PubMed Abstract ]

Grahl, N., Puttikamonkul, S., Macdonald, J. M., Gamcsik, M. P., Ngo, L. Y., Hohl, T. M., and R. A. Cramer. In vivo Hypoxia and an Alcohol Dehydrogenase Influence the Fungal Pathogenesis of Invasive Pulmonary Aspergillosis. PloS Pathogens 7:e1002145, 2011.
[ The following link will open in a new window. PubMed Abstract ]

Rivera, A., Hohl, T. M., Collins, N., Leiner, I., Gallegos, A., Saijo, S., Coward, J. W., Iwakura, Y., and E. G. Pamer.Dectin-1 diversifies anti-fungal T cell responses by inhibiting T helper type 1 differentiation. J. Exp. Med. 208:369-381, 2011.
[ The following link will open in a new window. PubMed Abstract ]

Hohl, T.M., Rivera, A., Lipuma, L., Gallegos, A., Shi, C., Mack, M. and E. G. Pamer. Inflammatory monocytes facilitate adaptive CD4 T cell responses during respiratory fungal infection. Cell Host Microbe. 6:470-481, 2009.
[The following link will open in a new window. PubMed Abstract ]

Mircescu, M., Lipuma, L., van Rooijen, N., Pamer, E. G., and T. M. Hohl. Essential role for neutrophils but not alveolar macrophages at early time points following Aspergillus fumigatus infection. J. Infect. Dis. 200:647-656, 2009.
[The following link will open in a new window. PubMed Abstract ]

 

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