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Directory >> Shevin T. Jacob, MD, MPH

Faculty

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Shevin T. Jacob, MD, MPH

  • Acting Assistant Professor, Allergy and Infectious Diseases, Department of Medicine
  • Associate Director, International Respiratory and Severe Illness Center
    University of Washington

Dr. Jacob's research focuses on the management, epidemiology and pathogenesis of sepsis syndromes in resource-constrained settings. He is currently based in Uganda as the co-Principal Investigator for a multi-site randomized controlled trial to evaluate the efficacy of a management bundle for adult sepsis tailored to resource-constrained settings, to comprehensively describe the microbiologic etiologies of severe sepsis in Uganda, and to identify common pathogenic pathways of septic shock using a systems biology approach. This research is part of a larger multi-national research consortium called the Austere environment Consortium for Enhanced Sepsis Outcomes (ACESO) for which Dr. Jacob is the Consortium Deputy Director and Uganda Country Director.

Dr. Jacob has also served as a consultant to the World Health Organization (WHO) since 2009 as part of various working groups to improve the clinical management of sepsis and other severe illnesses in resource-constrained settings. He is one of 8 overall technical editors for the WHO Integrated Management of Adolescent and Adult Illness (IMAI) District Clinician Manual and has helped to develop a related training course focusing on triage, emergency management of severe illness and the clinician’s role in disease surveillance, infection control and outbreak response. This training course and post-training quality improvement efforts are currently being implemented at Ugandan government hospitals by Walimu, a Uganda-based non-government organization for which Dr. Jacob is a co-founder and serves as a member of the Board of Directors. In addition, during the 2013-2015 Ebola outbreak in West Africa, Dr. Jacob was deployed by the WHO to assist in the clinical management of patients with Ebola Virus Disease (EVD) and mentor health workers caring for EVD in Guinea, Sierra Leone, and Liberia using training materials and a curriculum which he helped develop for the WHO. He also teaches a module on critical illness management in resource-limited settings for the East African Diploma in Tropical Medicine and Hygiene. In addition, in collaboration with colleagues from the Division of Pulmonary and Critical Care, he co-founded the University of Washington International Respiratory and Severe Illness Center (INTERSECT).

Selected Publications

Jacob ST, Moore CC, Banura P, et al. Severe sepsis in two Ugandan hospitals: a prospective observational study of management and outcomes in a predominantly HIV-1 infected ppulation. PLoS ONE. 2009; 4(11): 1-12.
PLoS One Abstract

Jacob ST, Banura P, Baeten JM,et al.  The impact of early monitored management on survival in hospitalized adult Ugandan patients with severe sepsis: a prospective intervention study. Crit Care Med. 2012; 40(7): 2050-8.
PubMed Abstract

Jacob ST, Lim M, Banura P, et al. Integrating sepsis management recommendations into clinical care guidelines for district hospitals in resource-limited settings: the necessity to augment new guidelines with future research. BMC Med. 2013; 11: 107.
PubMed Abstract

Jacob ST, Pavlinac PB, Nakiyingi L, et al. Mycobacterium tuberculosis bacteremia in a cohort of HIV-infected patients hospitalized with severe sepsis in Uganda: high frequency, low clinical suspicion and derivation of a clinical prediction score. PLoS One. 2013; 8(8): e70305.
PLoS One Abstract

Bah EI, Lamah MC, Fletcher T, Jacob ST, et al. Clinical Presentation of Patients with Ebola Virus Disease in Conakry, Guinea. N Eng J Med. 2015; 372(1): 40-7.
NEJM Abstract

Brett-Major DM, Jacob ST, Jacquerioz FA, et al. Being Ready to Treat Ebola Virus Disease Patients. Am J Trop Med Hyg. 2015; 92(2): 233-7.
PubMed Abstract

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