Faculty

• University of Washington


• Email: sjacob2@uw.edu

Shevin T. Jacob, MD, MPH

• Acting Instructor, Division of Allergy & Infectious Diseases
  Department of Medicine
  University of Washington
• Associate Director, International Respiratory and Severe Illness Center
  Department of Medicine
  University of Washington

Dr. Jacob’s research focuses on the management, epidemiology and pathogenesis of sepsis syndromes in resource-limited settings.  He is currently based in Uganda as the UW Principal Investigator for a multi-site randomized controlled trial to evaluate the efficacy of a management bundle for sepsis in resource-limited studies and to identify common pathogenic pathways of septic shock using a systems biology approach. The research in Uganda is primarily funded through the United States Department of Defense and is part of a larger multi-national research consortium called the Austere environment Consortium for Enhanced Sepsis Outcomes (ACESO) for which Dr. Jacob is the Consortium Deputy Director and Uganda Country Director.   As part of this research, he will be describing the epidemiology, establishing clinical correlates, evaluating diagnostics and developing management guidelines for sepsis from Mycobacterium tuberculosis, the most common etiology of sepsis among HIV-infected patients in sub-Saharan Africa.

Dr. Jacob is also currently working on a US Department of Defense-funded project to develop and validate novel multiplex point-of-care devices to improve diagnosis and bio-surveillance of tropical infectious diseases.  His work on this project involves collaborations with investigators in Peru, Kenya, Thailand, Cambodia and Northern Australia. 

To complement his research, Dr. Jacob has also served as a consultant to the World Health Organization since 2009 as part of various working groups to improve the clinical management of sepsis and other severe illnesses in resource-limited settings.  He is one of 8 overall technical editors for the recently published WHO Integrated Management of Adolescent and Adult Illness (IMAI) District Clinician Manual and has helped to develop a related training course focusing on triage, emergency management of severe illness and the clinician’s role in disease surveillance, infection control and outbreak response.  He also teaches a module on critical illness management in resource-limited settings for the East African Diploma in Tropical Medicine and Hygiene.  In addition, in association with colleagues from the Division of Pulmonary and Critical Care, he co-founded the University of Washington International Respiratory and Severe Illness Center (INTERSECT). 

Selected Publications

Becker JU, Theodosis C, Jacob ST, Wira CR, Groce NE.  Surviving sepsis in low-income and middle-income countries: new directions for care and research.  Lancet ID.  2009; 9: 577-582.
[ PubMed Abstract]

Jacob ST, Moore CC, Banura P, Pinkerton R, Meya D, Opendi P, Reynolds SJ, Kenya-Mugisha N, Mayanja-Kizza H, Scheld WM. Severe Sepsis in Two Ugandan Hospitals: a Prospective Observational Study of Management and Outcomes in a Predominantly HIV-1 Infected Population. PLoS ONE.  2009; 4(11): 1-12.
[ PLoS One Abstract]

Jacob ST, West TE, Banura P.  Fitting a square peg into a round hole: are the current Surviving Sepsis Campaign guidelines feasible for Africa? Critical Care. 2011; 15(1): 117.
[ PubMed Abstract]

Jacob ST, Banura P, Baeten JM, Moore CC, Nakiyingi L, Burke R, Horton C, Iga B, Wald A, Reynolds SJ, Mayanja-Kizza H, Scheld WM.  The impact of early monitored management on survival in hospitalized adult Ugandan patients with severe sepsis: a prospective intervention study. Critical Care Medicine.  2012; 40(7): 2050-58.
[ PubMed Abstract]

Doka NI, Jacob ST, Banura P, Moore CC, Meya D, Mayanja-Kizza Harriet, Reynolds SJ, Scheld WM, Yuan W.  Enrichment of HIV-1 Subtype AD Recombinants in a Ugandan Cohort of Severely Septic Patients” PLoS One. 2012; 7(10): e48356.
[ PubMed Abstract]

Jacob ST, Lim M, Banura P, Bhagwanjee S, Bion J, Cheng AC, Cohen H, Farrar J, Gove S, Hopewell P, Moore CC, Roth C, West TE. Integrating sepsis management recommendations into clinical care guidelines for district hospitals in resource-limited settings: the necessity to augment new guidelines with future research. BMC Med. 2013; 11:107.
[ PubMed Abstract]

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