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Directory >> Christine Johnston, MD, MPH


Contact Information

Christine Johnston, MD, MPH

  • Associate Professor, Division of Allergy and Infectious Disease
    Associate Medical Director, Virology Research Clinic
  • University of Washington
  • Research Affiliate
  • Fred Hutchinson Cancer Research Center

Dr. Johnston is a physician-scientist who performs clinical studies of genital herpes simplex virus type 2 (HSV-2) infection, focused on characterizing spatial localization of subclinical genital shedding and host-virus interactions. In addition, research interests include studies of existing and novel antiviral agents to suppress HSV-2 genital shedding, and the interactions between HSV-2 and coinfections in the female genital tract, specifically HIV-1 and bacterial vaginosis.

Selected Publications

Johnston C, Magaret A, Selke S, Remington M, Corey L, Wald A. Herpes simplex virus viremia during primary genital infection. J Infect Dis. 2008; 198(1): 31-4.
PubMed Abstract

Johnston C, Orem J, Okuku F, Kalinaki M, Saracino M, Mbidde-Katongole E. Impact of HIV infection and Kaposi Sarcoma on human herpesvirus-8 mucosal and replication and dissemination in Uganda. PLoS ONE. 2009; 4(1): e4222.
PubMed Abstract

Tronstein E, Johnston C, Huang M, et al. Genital shedding of herpes simplex virus among symptomatic and asymptomatic persons with HSV-2 infection. JAMA. 2011; 305(14): 1441-9.
PubMed Abstract

Johnston C, Koelle DM, Wald A. HSV-2: in pursuit of a vaccine. J Clin Invest. 2011; 121(12), 4600-9.
PubMed Abstract

Johnston C, Saracino M, Kuntz S, et al. Standard-dose and high-dose daily antiviral therapy for short episodes of genital HSV-2 reactivation: three randomised, open-label, cross-over trials. Lancet. 2012; 179(9816): 641-7.
PubMed Abstract

Johnston C, Koelle DM, Wald A.  Current status and prospect for development of an HSV vaccine.  Vaccine 2014; 32(14): 1553-60.
PubMed Abstract

Johnston C, Zhu J, Jing L, Laing KJ, McClurkan C, Klock A, Diem K, Jin L, Stanaway J, Tronstein E, Kwok W, Huang M, Selke S, Fong Y, Magaret A, Koelle DM, Wald A, Corey L.   Virologic and immunologic evidence of multifocal genital herpes simplex virus type 2 infection   J Virol 2014; 88 (9): 4921-31.  PMC pending.
Journal of Virology Abstract

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