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Directory >> Michael G. Katze, PhD


Contact Information

Michael G. Katze, PhD

  • Associate Director, Washington National Primate Research Center
  • Professor, Department of Microbiology
  • University of Washington

Research in the Katze lab is focused on the use of systems biology approaches to define and model virus-host interactions, innate immune signaling, and the varied strategies used by viruses to evade cellular defense mechanisms. The lab studies a wide range of viral pathogens, including pandemic and highly pathogenic avian influenza viruses, SARS and MERS coronaviruses, Ebola virus, and human and simian immunodeficiency viruses. The group is also spearheading efforts to develop genomic resources for nonhuman primate, ferret, and Syrian hamster models of human virus infection.

Research projects in the laboratory include:

  • Division of Nonhuman Primate Systems Biology at the Washington National Primate Research Center; focused on developing genomic and immunologic resources to enhance the use of nonhuman primates as models for human virus infection.

  • Nonhuman Primate Core Functional Genomics Laboratory for AIDS Vaccine Research and Development; an NIAID contract-supported program to measure vaccine responses at the molecular level and to discover markers that may be prognostic in assessing if a vaccination will protect against HIV.

  • Nonhuman primate reference transcriptome resources; uses next-generation sequencing technologies to generate information about the structure of nonhuman primate genomes and the diversity of transcripts that these genomes express

  • Transcriptome resources for comparative primate models of lentivirus Infection; focused on generating whole-transcriptome reference databases for immune cell types at baseline and during infection with HIV or SIV with an emphasis on comparative models of pathogenic and non-pathogenic infection

  • Mouse Collaborative Cross virus infection models; uses Collaborative Cross recombinant inbred mouse lines to identify genes and gene networks that regulate the induction, kinetics, and magnitude of innate immune, and , inflammatory responses following Ebola virus infection.

  • Center for Research in Diagnostics and Discovery; focused on the use of host-response signatures to rapidly identify emergent pathogens and to guide medical treatments to contain outbreaks.

Selected Publications

Barrenas, F., R.E. Palermo, B. Agricola, M.B. Agy, L. Aicher, V. Carter, L. Flanary, R.R. Green, R. McLain, Q. Li, W. Lu, R. Murane, X. Peng, M.J. Thomas, J.M. Weiss. D.M. Anderson, and M.G. Katze. 2014. Deep transcriptional sequencing of mucosal challenge compartment from rhesus macaques acutely infected with simian immunodeficiency virus implicates loss of cell adhesion preceding immune activation. J. Virol. 88:7962-7972.
PubMed Abstract

Josset, L., N. Tchitchek, L.E. Gralinski, M.T. Ferris, A.J. Eisfeld, R. Green, M.J. Thomas, J. Tisoncik-Go, G.P. Schroth, Y. Kawaoka, F. Pardo-Manuel de Villena, R.S. Baric, M.T. Heise, X. Peng, and M.G. Katze. 2014. Annotation of long non-coding RNAs expressed in Collaborative Cross founder mice in response to respiratory virus infection reveals a new class of interferon-stimulated transcripts. RNA Biol. 11:875-890.
PubMed Abstract

Morrison, J., L. Josset, N. Tchitchek, J. Chang, J.A. Belser, D.E. Swayne, M.J. Pantin-Jackwood, T.M. Tumpey, and M.G. Katze. 2014. H7N9 and other pathogenic avian influenza viruses elicit a three-pronged transcriptomic signature that is reminiscent of 1918 influenza virus and is associated with lethal outcome in mice. J. Virol. 88:10556-10568.
PubMed Abstract

Peng, X. J. Alfoldi, K. Gori, A.J. Eisfeld, S.R. Tyler, J. Tisoncik-Go, D. Brawand, L. Law, N. Skunca, M. Hatta, D.J. Gasper, S.M. Kelly, J. Chang, M. Thomas, J. Johnson, A.M. Berlin, M. Lara, P. Russell, R. Swofford, J. Turner-Maier, S. Young, T. Hourlier, B. Aken, S. Searle, X. Sun, Y. Yi, M. Suresh, T.M. Tumpey, A. Siepel, S.M. Wisely, C. Dessimoz, Y. Kawaoka, B.W. Birren, K. Lindblad-Toh, F. Di Palma, J.F. Engelhardt, R.E. Palermo, and M.G. Katze. 2014. The draft genome sequence of the ferret (Mustela putorius furo) facilitates study of human respiratory disease. Nature Biotechnol. 32:1250-1255.
PubMed Abstract

Rasmussen, A.L., A. Okumura, M.T. Ferris, R. Green, F. Feldmann, S.M. Kelly, D.P. Scott, D. Safronetz, E. Haddock, R. LaCasse, M.J. Thomas, P. Sova, V.S. Carter, D.R. Miller, G.D. Shaw, M.J. Korth, M.T. Heise, R.S Baric, F. Pard-Manuel de Villena, H. Feldmann, and M.G. Katze. 2014. Host genetic diversity enables Ebola hemorrhagic fever pathogenesis and resistance. Science. 346:987-981.
PubMed Abstract


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