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Directory >> W. Conrad Liles, MD, PhD


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W. Conrad Liles, MD, PhD

  • Associate Chair and Professor of Medicine, Department of Medicine
    University of Washington
  • Co-Director, Molecular Medicine Training Program
    University of Washington

Dr. Liles returned to the University of Washington in 2012 from the University of Toronto, where he was Vice-Chair and Professor of Medicine, Director of the Division of Infectious Diseases, and the Canada Research Chair in Infectious Diseases and Inflammation. In addition to his duties as Professor and Associate Chair, Dr. Liles serves as Co-Director of the Molecular Medicine Training Program at the University of Washington. The overall mission of his research program is to investigate clinical problems at the bench, in order to gain novel insights into disease pathogenesis and to develop novel therapeutic approaches to important clinical problems. His laboratory focuses on the role of dysregulated host responses in the pathogenesis of infectious diseases of public health importance. A guiding principle of his research program is rapid translation of experimental insights and advances gained in the laboratory to the clinical bedside. Areas of current research include:

  1. The molecular immunopathogenesis of malaria, one of the major causes of infection-related morbidity and mortality worldwide
  2. Sepsis, a major cause of tissue injury and organ dysfunction in patients hospitalized in intensive care units
  3. Hemolytic-uremic syndrome (HUS)
  4. Severe influenza
  5. Acute respiratory distress syndrom (ARDS) and multiple organ dysfunction syndrome (MODS)
  6. The role and regulation of endothelial activation/dysfunction in life-threatening infectious diseases.

The role of innate immunity and inflammation in the development of effective acquired/adaptive immunity to infectious diseases is an emerging interest in his laboratory, as is prognostic host-derived biomarker discovery. His research utilizes a variety of molecular and cellular biology technologies (e.g., transfection/transduction strategies, real-time PCR, siRNA technology, Western blot, ELISA, etc.), expression microarray technology, mesenchymal stem cell and adoptive cell transfer technology, cell culture, work with patient specimens, and clinically relevant mouse models of malaria, sepsis, and acute lung injury. His research laboratory is located in the SLU 3.1 facility, where he is a member of CERID.

Selected Publications

Mei, SHJ, Haitsma, JJ, Santos, CC dos, Deng, Y, Lai, PFH, Slutsky, AS, Liles WC, Stewart, DJ. Mesenchymal stem cells reduce inflammation while enhancing bacterial clearance and improving survival in sepsis.. Am J Respir Crit Care Med. 2010; 182(8): 1047-57.
PubMed Abstract

Ricciuto, DR, Santos, CC dos, Hawkes, M, Toltl, LJ, Conroy, AL, Rajwans, N, Lafferty, EI, Cook, DJ, Fox-Robichaud, A, Kahnamoui, K, Kain, KC, Liaw, PC, Liles WC. Angiopoietin-1 and angiopoietin-2 as clinically informative prognostic biomarkers of morbidity and mortality in severe sepsis. Crit Care Med. 2011; 39(4): 702-10.
• PubMed Abstract

dos Santos C, Murthy S, Hu P, Shan Y, Haitsma JJ, Mei SHJ, Stewart DJ, Liles WC. Network analysis of transcriptional responses induced by mesenchymal stem cell treatment of experimental sepsis. Am J Pathol.2012; 181(5): 1681-92.
PubMed Abstract

Lovegrove, FE, Tangpukdee, N, Opoka, RO, Lafferty, EI, Rajwans, N, Hawkes, M, Krudsood, S, Looareesuwan, S, John, CC, Liles WC, Kain, KCl. Serum angiopoietin-1 and -2 levels discriminate cerebral malaria from uncomplicated malaria and predict clinical outcome in African children. PLoS One. 2009; 4(3): e4912

Lovegrove, FE, Gharib, SA, Peña-Castillo, L, Patel, SN, Ruzinski, JT, Hughes, TR, Liles WC, Kain, KC. Parasite burden and CD36-mediated sequestration are determinants of acute lung injury in an experimental malaria model. PLoS Pathog. 2008; 4(5): e1000068.
PubMed Abstract

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