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Directory >> Jairam Lingappa, MD, PhD

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Jairam Lingappa, MD, PhD

  • Associate Professor, Departments of Medicine and Global Health
    Associate Director, International Clinical Research Center, Department of Global Health
    Adjunct Associate Professor, Department of Pediatrics
  • University of Washington

Dr. Lingappa has been a faculty member at the University of Washington since 2004 and is currently an Associate Professor in the Departments of Global Health and Medicine and Adjunct Associate Professor in the Department of Pediatrics.  He received his B.A. in Physics from Swarthmore College, Ph.D. in Biophysics at Harvard University, and M.D. at the University of California. He completed residency training in Pediatrics and a fellowship in Pediatric Infectious Diseases at the University of Washington.  From 1998 to 2003, prior to starting as a UW faculty, he served as an officer with the US Public Health Epidemic Intelligence Service and a medical epidemiologist at the U.S. Centers for Disease Control and Prevention. 

Since joining the UW faculty, he has collaborated with Drs. Connie Celum and Jared Baeten to conduct HIV-1 prevention clinical trials and observational studies in African heterosexual HIV-1 discordant couples. Most recently, his activities have focused on using samples and data from those prospective cohorts to conduct translational research studies to understand the pathogenesis of HIV-1 sexual transmission and particularly to identify host biological correlates of protection from HIV-1 infection.


Current ongoing research projects that may be of interest to fellows include:

  • Exploration of the relationship of host response to HIV exposure includinganalysis of whole genome sequence data to identify predictors of hostresistance to HIV;
  • Use of mass spectrometry and gene expression profiling of genital mucosal samples to quantify host response to HIV-1 risk exposures;

  • Selected Publications


    Agrawal A, Lingappa J, Leppla SH, Agrawal S, Jabbar A, Quinn C, Pulendran B. Impairment of dendritic cells and adaptive immunity by anthrax lethal toxin. Nature. 2003; 424(6946): 329-34.
    PubMed Abstract

    Celum C, Wald A, Lingappa JR, et al for the Partners in Prevention HSV/HIV Transmission Study Team. Acyclovir and transmission of HIV-1 from persons infected with HIV-1 and HSV-2. N Engl J Med. 2010; 362(5): 427-39.
    PMID:
    20089951.
    PubMed Abstract

    Lingappa JR, Baeten JM, Wald A, et al for the Partners in Prevention HSV/HIV Transmission Study Team. Daily acyclovir for HIV-1 disease progression in people dually infected with HIV-1 and herpes simplex virus type 2: a randomised placebo-controlled trial. Lancet. 2010; 375(9717): 824-33.
    PMCID: PMC2877592.
    PubMed Abstract

    Lingappa JR, Petrovski S, Kahle E, et al for the Partners in Prevention HSV/HIV Transmission Study Team. Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure. PLoS One. 2011; 6(12): e28632.
    PMID: 22174851
    PMC 3236203
    • PLoS One Abstract

    Cohen CR, Lingappa JR, Baeten JM, et al. Bacterial vaginosis associated with increased risk of female-to-male HIV-1 transmission: a prospective cohort analysis among African couples.PLoS Med. 2012; 9(6): e1001251.
    PMC 3383741.
    PubMed Abstract

    Mackelprang RD, Baeten JM, Donnell D, Celum C, Farquhar C, de Bruyn G, Essex M, McElrath MJ, Nakku-Joloba E, Lingappa JR for the Partners in Prevention HSV/HIV Transmission Study Team. Quantifying ongoing HIV-1 exposure in HIV-1 serodiscordant couples to identify individuals with potential host resistance to HIV-1. J Infect Dis. 2012; 206(8): 1299-1308.
    PubMed Abstract


    Mackelprang R, Bigham AW, Celum C, de Bruyn G, Beima K, John-Stewart G, Ronald A, Mugo NR, Buckingham KJ, Bamshad MJ, Mullins JI, McElrath MJ, Lingappa JR. Toll-like receptor polymorphism associations with HIV-1 outcomes among sub-Saharan Africans. J Infect Dis. Published online 10 Dec 2013. PMCID
    PubMed Abstract