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Directory >> Jeanne M. Marrazzo, MD, MPH

Faculty

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Jeanne M. Marrazzo, MD, MPH

  • Professor, Division of Allergy and Infectious Diseases, Department of Medicine
    University of Washington

Current research is centered in several areas:

  • Biomedical prevention of HIV, especially evaluation of vaginal and oral pre-exposure prophylaxis (PrEP) for prevention of HIV acquisition in African women;
  • Interactions between hormonal contraceptives and cervicovaginal inflammation and infection;
  • Molecular epidemiology of vaginal the vaginal microbiome, including bacterial vaginosis (BV), and role of newly defined bacteria in the pathogenesis and diagnosis of BV;
  • Sexually transmitted infections and health care seeking behavior in LGBTQ populations, including STD in men who have sex with men and in HIV care settings, cervical neoplasia and BV in women who report sex with women;
  • Diagnosis and epidemiology of bacterial STDs.
  • Evaluation of a contraceptive vaginal ring on the vaginal microbiome, local immunity and HIV shedding in Kenyan women.
  • Evaluation of a contraceptive vaginal ring on the vaginal microbiome and local immunity in U.S. women.

Our work has expanded the microbiologic spectrum of BV-associated organisms, and we continue to study predictors of infection with these bacteria, their role in diagnosis of vaginal infections, the host immune response in BV, and potential reservoirs (including sex partners) that may help explain BVs association with specific sexual practices. We are also very interested in the effects that different types of hormonal contraception may have on the genital microbiome and on risk of and activity of critical genital infections, including genital herpes.

The major objectives of work related to HIV PrEP is to evaluate the effectiveness of oral vs. vaginally delivered antiretroviral medications in preventing HIV acquisition in young HIV-uninfected women in sub-Saharan Africa. Research related to other STDs seeks to define better point-of-care diagnostic tests for common pathogens. Collaborators in these efforts include Dr. David Fredricks, Dr. Thomas Hawn, Dr. Jared Baeten, and Dr. Connie Celum.

As the Medical Director of the Seattle STD/HIV Prevention Training Center, I am also invested in delivering and evaluating excellent educational offerings to providers in practice and to medical practitioners in training. See www.seattlestdhivptc.org for more information.


Selected Publications


Marrazzo JM, Fiedler T, Srinavasan S, et al. Extravaginal reservoirs of vaginal bacteria as risk factors for bacterial vaginosis. J Infect Dis. 2012; 205(10): 1580-8.
• PubMed Abstract

Marrazzo JM, Thomas KK, Fiedler TL, Ringwood K, Fredricks DN. Risks for acquisition of bacterial vaginosis among women who report sex with women: a cohort study. PLoS One. 2010; 5(6): e11139.
PubMed Abstract

Mitchell C, Manhart LE, Thomas KK, Agnew K, Marrazzo JM. Effect of sexual activity on vaginal colonization with hydrogen peroxide-producing lactobacilli and Gardnerella vaginalis. Sex Transm Dis. 2011; 38(12): 1137-44. PMCID: PMC3217189.
• PubMed Abstract


Marrazzo JM, Cates W. Interventions to prevent sexually transmitted infections, including HIV infection. Clinical infectious diseases: an official publication of the Infectious Diseases Society of America. Clin Infect Dis. 2011; 53(Suppl 3): S64-78. PMCID: PMC3213401.
PubMed Abstract


Marrazzo JM, Thomas KK, Fiedler TL, et al. Relationship of specific vaginal bacteria and bacterial vaginosis treatment failure in women who have sex with women. Ann Intern Med. 2008; 149(1): 20-8.
PubMed Abstract


Fredricks DN, Fiedler TL, Marrazzo JM. Molecular identification of bacteria associated with bacterial vaginosis. N Engl J Med. 2005; 353(18): 1899-911.
PubMed Abstract

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