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Directory >> Elizabeth Ann Misch, MD


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Elizabeth Ann Misch, MD

  • Acting Assistant Professor, Division of Allergy and Infectious Diseases
  • University of Washington

My research focuses on how the human innate immunity recognizes intracellular pathogens and how variants in innate immune genes impact susceptibility to these pathogens.   Specifically, we have investigated human genetic variants in Toll-like receptors 1 and 6 and CD180 that alter susceptibility to Mycobacterium leprae, M. tuberculosis (MTb), and Legionella pneumophila, the etiologic agent of Legionnaires’ Disease.  We have characterized a Toll-like receptor 1 polymorphism (T1805G) that confers targeted immunodeficiency toward pathogens sensed through this receptor and showed that TLR1-deficient humans have decreased inflammatory responses to M. leprae.  We are investigating the effects of this TLR1 variant on human macrophage and dendritic cell responses to Mycobacterium tuberculosis.  In addition, we have identified TLR6 and CD180 variants that are associated with altered risk of Legionnaires’ Disease.  We are also exploring the cellular and molecular mechanism for enhanced growth of L. pneumophila in Cd180-/- murine macrophages.

My clinical interests include general infectious disease, the diagnosis and management of infections in solid organ transplantation, mycobacteria, tropical medicine, and endemic fungal infections.

Selected Publications

Hawn TR, Misch EA, Dunstan SJ, et al. A common human TLR1 polymorphism regulates the innate immune response to lipopeptides. Eur J Immunol. 2007; 37(8): 2280-9. PMID: 17595679.
PubMed Abstract

Misch EA, Hawn TR. Toll-like receptor polymorphisms and susceptibility to human disease. Clin Sci. 2008; 114: 347-60. PMID: 18230059.
PubMed Abstract

Misch EA, MacDonald M, Ranjit C, et al. Human TLR 1 deficiency is associated with impaired mycobacterial signaling and protection from leprosy reversal reaction. PLoS Negl Trop Dis. 2008; 2(5): e231. PMID: 18461142.
PubMed Abstract

Sapkota BR, Macdonald M, Berrington WR, Misch EA, et al. Association of TNFa, MBL, and VDR polymorphisms with leprosy phenotypes. Hum Immunol. 2010; 71(10): 992-8. PMID: 20650301.
PubMed Abstract

Misch EA, Berrington WR, Vary JC Jr, Hawn TR. Leprosy and the human genome. Microbiol Mol Biol Rev. 2010; 74: 589-620. PMID: 21119019.
ASM Abstract

Misch EA, Verbon A, Prins J, Skerrett SJ, Hawn TR. A TLR6 polymorphism is associated with increased risk of Legionnaire's Disease. Genes and Immun. Epub 2013 July.
Genes and Immunity Abstract

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