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Directory >> James Mullins, PhD

Faculty

Contact Information

James Mullins, PhD

  • Professor, Departments of Microbiology, Medicine and Laboratory Medicine
  • University of Washington

The Mullins laboratory uses the techniques of molecular, computational, and virus biology to provide basic insights into the HIV-human host relationship. Our goals are to assist the fight against AIDS by gaining insight into the establishment of infection and the development of the disease in order to assist creation of effective vaccines and to refine therapies. Current effort utilizes a variety of techniques to define and understand the implications of HIV's extraordinary evolutionary rate and ensuing genetic diversity as well as testing new approaches to vaccine immunogen and therapeutics design. These techniques include virology, molecular biological and statistical analysis of nucleotide sequences. Collaborators include Drs. McElrath, Collier, Horton, Mittler, Zhu, Gottlieb, Campbell, Lingappa, Corey and Celum.


Selected Publications

Mackelprang, R.D., Carrington, M., Thomas, K.K., Hughes, J.P., Baeten, J.M., Wald, A., Farquhar, C., Fife, K., Campbell, M.S., Kapiga, S., Gao, X., Mullins, J.I., and Lingappa, J.R., Host Genetic and Viral Determinants of Hiv-1 Rna Set Point among Hiv-1 Seroconverters from Sub-Saharan Africa, J Virol 89 (4), 2104-11 (2015)
PubMed Abstract

Edlefsen, P.T., Rolland, M., Hertz, T., Tovanabutra, S., Gartland, A.J., Decamp, A.C., Magaret, C.A., Ahmed, H., Gottardo, R., Juraska, M., Mccoy, C., Larsen, B.B., Sanders-Buell, E., Carrico, C., Menis, S., Bose, M., Team, R.V.S., Arroyo, M.A., O'connell, R.J., Nitayaphan, S., Pitisuttithum, P., Kaewkungwal, J., Rerks-Ngarm, S., Robb, M.L., Kirys, T., Georgiev, I.S., Kwong, P.D., Scheffler, K., Pond, S.L., Carlson, J.M., Michael, N.L., Schief, W.R., Mullins, J.I., Kim, J.H., and Gilbert, P.B., Comprehensive Sieve Analysis of Breakthrough Hiv-1 Sequences in the Rv144 Vaccine Efficacy Trial, PLoS Comput Biol 11 (2), e1003973 (2015) PMC4315437
PubMed Abstract

Wagner, T.A., Mclaughlin, S., Garg, K., Cheung, C.Y., Larsen, B.B., Styrchak, S., Huang, H.C., Edlefsen, P.T., Mullins, J.I., and Frenkel, L.M., Hiv Latency. Proliferation of Cells with Hiv Integrated into Cancer Genes Contributes to Persistent Infection, Science 345 (6196), 570-3 (2014) PMC4230336
PubMed Abstract

Sunshine, J., Kim, M., Carlson, J.M., Heckerman, D., Czartoski, J., Migueles, S.A., Maenza, J., Mcelrath, M.J., Mullins, J.I., and Frahm, N., Increased Sequence Coverage through Combined Targeting of Variant and Conserved Epitopes Correlates with Control of Hiv Replication, J Virol 88 (2), 1354-65 (2014) PMC391164
PubMed Abstract

Melhem, N.M., Smith, K.N., Huang, X.L., Colleton, B.A., Jiang, W., Mailliard, R.B., Mullins, J.I., and Rinaldo, C.R., The Impact of Viral Evolution and Frequency of Variant Epitopes on Primary and Memory Human Immunodeficiency Virus Type 1-Specific Cd8(+) T Cell Responses, Virology 450-451, 34-48 (2014) PMC4110927
PubMed Abstract

Manocheewa, S., Lanxon-Cookson, E.C., Liu, Y., Swain, J.V., Rao, U., Maust, B., Sunshine, J.E., Kim, M., Rolland, M., and Mullins, J.I., Pairwise Growth Competition Assay for Determining the Replication Fitness of Human Immunodeficiency Viruses, Journal of Visualized Experiments, In Press (2014)
PubMed Abstract

Liu, Y., Rao, U., Mcclure, J., Konopa, P., Manocheewa, S., Kim, M., Chen, L., Troyer, R.M., Tebit, D.M., Holte, S., Arts, E.J., and Mullins, J.I., Impact of Mutations in Highly Conserved Amino Acids of the Hiv-1 Gag-P24 and Env-Gp120 Proteins on Viral Replication in Different Genetic Backgrounds, PLoS One 9 (4), e94240 (2014) PMC3979772
PubMed Abstract

Kulkarni, V., Valentin, A., Rosati, M., Rolland, M., Mullins, J.I., Pavlakis, G.N., and Felber, B.K., Hiv-1 Conserved Elements P24ce DNA Vaccine Induces Humoral Immune Responses with Broad Epitope Recognition in Macaques, PLoS One 9 (10), e111085 (2014) PMC4206485
PubMed Abstract

Kulkarni, V., Valentin, A., Rosati, M., Alicea, C., Singh, A.K., Jalah, R., Broderick, K.E., Sardesai, N.Y., Le Gall, S., Mothe, B., Brander, C., Rolland, M., Mullins, J.I., Pavlakis, G.N., and Felber, B.K., Altered Response Hierarchy and Increased T-Cell Breadth Upon Hiv-1 Conserved Element DNA Vaccination in Macaques, PLoS One 9 (1), e86254 (2014) PMC3900501
PubMed Abstract

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