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Directory >> James Mullins, PhD

Faculty

Contact Information

James Mullins, PhD

  • Professor, Departments of Microbiology, Medicine and Laboratory Medicine
  • University of Washington

The Mullins laboratory uses the techniques of molecular, computational, and virus biology to provide basic insights into the HIV-human host relationship. Our goals are to assist the fight against AIDS by gaining insight into the establishment of infection and the development of the disease in order to assist creation of effective vaccines and to refine therapies. Current effort utilizes a variety of techniques to define and understand the implications of HIV's extraordinary evolutionary rate and ensuing genetic diversity as well as testing new approaches to vaccine immunogen and therapeutics design. These techniques include virology, molecular biological and statistical analysis of nucleotide sequences. Collaborators include Drs. McElrath, Collier, Horton, Mittler, Zhu, Gottlieb, Campbell, Lingappa, Corey and Celum.


Selected Publications

Bull, M.E., Heath, L.M., Mckernan- Mullins, J.I., Kraft, K.M., Acevedo, L., Hitti, J.E., Cohn, S.E., Tapia, K.A., Holte, S.E., Dragavon, J.A., Coombs, R.W., Mullins, J.I., and Frenkel, L.M., Human Immunodeficiency Viruses Appear Compartmentalized to the Female Genital Tract in Cross-Sectional Analyses but Genital Lineages Do Not Persist over Time, J Infect Dis 207 (8), 1206-15 (2013) PMC3603533
PubMed Abstract


Campbell, M.S., Kahle, E.M., Celum, C., Lingappa, J.R., Kapiga, S., Mujugira, A., Mugo, N.R., Fife, K.H., Mullins, J.I., Baeten, J.M., and Partners in Prevention, H.S.V.H.I.V.T.S.T., Plasma Viral Loads During Early HIV-1 Infection Are Similar in Subtype C- and Non-Subtype C-Infected African Seroconverters, J Infect Dis 207 (7), 1166-70 (2013) PMC3583276
PubMed Abstract


Kulkarni, V., Rosati, M., Valentin, A., Ganneru, B., Singh, A.K., Yan, J., Rolland, M., Alicea, C., Beach, R.K., Zhang, G.M., Le Gall, S., Broderick, K.E., Sardesai, N.Y., Heckerman, D., Mothe, B., Brander, C., Weiner, D.B., Mullins, J.I., Pavlakis, G.N., and Felber, B.K., HIV-1 P24(Gag) Derived Conserved Element DNA Vaccine Increases the Breadth of Immune Response in Mice, PLoS One 8 (3), e60245 (2013) PMC3610668
PubMed Abstract


Kunwar, P., Hawkins, N., Dinges, W.L., Liu, Y., Gabriel, E.E., Swan, D.A., Stevens, C.E., Maenza, J., Collier, A.C., Mullins, J.I., Hertz, T., Yu, X., and Horton, H., Superior Control of HIV-1 Replication by Cd8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design, PLoS One 8 (5), e64405 (2013) PMC3669284
PubMed Abstract


Lanxon-Cookson, E.C., Swain, J.V., Manocheewa, S., Smith, R.A., Maust, B., Kim, M., Westfall, D., Rolland, M., and Mullins, J.I., Factors Affecting Relative Fitness Measurements in Pairwise Competition Assays of Human Immunodeficiency Viruses, J Virol Methods 194 (1-2), 7-13 (2013) PMC3825816
PubMed Abstract


Larsen, B.B., Chen, L., Maust, B.S., Kim, M., Zhao, H., Deng, W., Westfall, D., Beck, I., Frenkel, L.M., and Mullins, J.I., Improved Detection of Rare HIV-1 Variants Using 454 Pyrosequencing, PLoS One 8 (10), e76502 (2013) PMC3788733
PubFacts


Lingappa, J.R., Thomas, K.K., Hughes, J.P., Baeten, J.M., Wald, A., Farquhar, C., De Bruyn, G., Fife, K.H., Campbell, M.S., Kapiga, S., Mullins, J.I.., Celum, C., and Partners in Prevention, H.S.V.H.I.V.T.S.T., Partner Characteristics Predicting HIV-1 Set Point in Sexually Acquired HIV-1 among African Seroconverters, AIDS research and human retroviruses 29 (1), 164-71 (2013) PMC3537302
PubMed Abstract


Mailliard, R.B., Smith, K.N., Fecek, R.J., Rappocciolo, G., Nascimento, E.J., Marques, E.T., Watkins, S.C., Mullins, J.I., and Rinaldo, C.R., Selective Induction of Ctl Helper Rather Than Killer Activity by Natural Epitope Variants Promotes Dendritic Cell-Mediated HIV-1 Dissemination, Journal of immunology 191 (5), 2570-80 (2013) PMC3786204
PubMed Abstract


Manocheewa, S., Swain, J.V., Lanxon-Cookson, E., Rolland, M., and Mullins, J.I., Fitness Costs of Mutations at the HIV-1 Capsid Hexamerization Interface, PLoS One 8 (6), e66065 (2013) PMC3681919
PubMed Abstract


Mclaren, P.J., Coulonges, C., Ripke, S., Van Den Berg, L., Buchbinder, S., Carrington, M., Cossarizza, A., Dalmau, J., Deeks, S.G., Delaneau, O., De Luca, A., Goedert, J.J., Haas, D., Herbeck, J.T., Kathiresan, S., Kirk, G.D., Lambotte, O., Luo, M., Mallal, S., Van Manen, D., Martinez-Picado, J., Meyer, L., Miro, J.M., Mullins, J.I., Obel, N., O'brien, S.J., Pereyra, F., Plummer, F.A., Poli, G., Qi, Y., Rucart, P., Sandhu, M.S., Shea, P.R., Schuitemaker, H., Theodorou, I., Vannberg, F., Veldink, J., Walker, B.D., Weintrob, A., Winkler, C.A., Wolinsky, S., Telenti, A., Goldstein, D.B., De Bakker, P.I., Zagury, J.F., and Fellay, J., Association Study of Common Genetic Variants and HIV-1 Acquisition in 6,300 Infected Cases and 7,200 Controls, PLoS Pathog 9 (7), e1003515 (2013) PMC3723635
PubMed Abstract


Rolland, M., Manocheewa, S., Swain, J.V., Lanxon-Cookson, E.C., Kim, M., Westfall, D.H., Larsen, B.B., Gilbert, P.B., and Mullins, J.I., HIV-1 Conserved-Element Vaccines: Relationship between Sequence Conservation and Replicative Capacity, J Virol 87 (10), 5461-7 (2013) PMC3648173
PubMed Abstract


Wagner, T.A., Mckernan, J.L., Tobin, N.H., Tapia, K.A., Mullins, J.I., and Frenkel, L.M., An Increasing Proportion of Monotypic HIV-1 DNA Sequences During Antiretroviral Treatment Suggests Proliferation of HIV-Infected Cells, J Virol 87 (3), 1770-8 (2013) PMC3554159
PubMed Abstract


Kulkarni, V., Valentin, A., Rosati, M., Alicea, C., Singh, A.K., Jalah, R., Broderick, K.E., Sardesai, N.Y., Le Gall, S., Mothe, B., Brander, C., Rolland, M., Mullins, J.I., Pavlakis, G.N., and Felber, B.K., Altered Response Hierarchy and Increased T-Cell Breadth Upon HIV-1 Conserved Element DNA Vaccination in Macaques, PLoS One 9 (1), e86254 (2014)
PubMed Abstract


Melhem, N.M., Smith, K.N., Huang, X.L., Colleton, B.A., Jiang, W., Mailliard, R.B., Mullins, J.I., and Rinaldo, C.R., The Impact of Viral Evolution and Frequency of Variant Epitopes on Primary and Memory Human Immunodeficiency Virus Type 1-Specific Cd8(+) T Cell Responses, Virology 450-451, 34-48 (2014)
PubMed Abstract


Sunshine, J., Kim, M., Carlson, J.M., Heckerman, D., Czartoski, J., Migueles, S.A., Maenza, J., Mcelrath, M.J., Mullins, J.I., and Frahm, N., Increased Sequence Coverage through Combined Targeting of Variant and Conserved Epitopes Correlates with Control of HIV Replication, J Virol 88 (2), 1354-65 (2014)
PubMed Abstract

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