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Directory >> Julie Overbaugh, PhD

Faculty

Julie Overbaugh, PhD

  • Member
    Fred Hutchinson Cancer Research Center

The emphasis of research in Dr. Overbaugh's laboratory is on various aspects of HIV-1 transmission and pathogenesis, with a particular focus on translational research.  She has worked closely with investigators in Kenya for the past 2 decades, including on a number of studies of mother-to-child and heterosexual transmission of HIV-1.  Studies in her lab are focused on understanding the biology of HIV transmission, particularly transmission to women and to infants, and defining immune mechanisms of protection. Key findings include 1) the identification of a transmission bottleneck that leads to selection for transmission of a small number of HIV variants; 2) characterization of viral diversity and antibody responses in disease, and 3) demonstration that HIV-infected individuals continue to be a risk for re-infection by other source partners.  Current studies including defining the specificity and ontogeny of the antibody response to HIV, identifying immune correlates of protection and defining Interferon-induced restrictions to HIV replication.  Dr. Overbaugh collaborates with Drs. Graham, John-StewartMcClelland and Richardson.


Selected Publications


Cortez V, Odem-Davis K, McClelland RS, Jaoko W, Overbaugh J.  HIV-1 superinfection in women broadens and strengthens the neutralizing antibody response.  PLoS Pathog. 8(3): e1002611, 2012.  
Plos Abstract

Mabuka J, Nduati R, Odem-Davis K., Peterson D, Overbaugh J.  HIV-specific antibodies capable of ADCC are common in breastmilk and are associated with reduced risk of transmission in women with high viral loads.  PLoS Pathog. 8(6): e1002739, 2012. 
PubMed Abstract

Ronen K, McCoy CO, Matsen FA, Boyd DF, Emery S, Odem-Davis K, Jaoko W, Mandaliya K, McClelland RS, Richardson BA, Overbaugh J.  HIV-1 superinfection occurs less frequently than initial infection in a cohort of high-risk Kenyan women.  PLoS Pathog. 9(8): e1003593, 2013.
PubMed Abstract

Goo L, Chohan V, Nduati R, Overbaugh J.  Early development of broad neutralizing antibodies in HIV-1 infected infants.  Nat Med., 20, 655-658, 2014.
Europe PubMed Abstract

Boyd DF, Peterson D, Haggarty BS, Jordan APO, Hogan MJ, Goo L, Hoxie JA, Overbaugh J.  Adapting HIV-1 to mediate entry with the macaque CD4 receptor alters antibody recognition by disrupting quaternary interactions with the trimer.  J. Virol. 89: 894-907, 2015.
PubMed Abstract

Milligan C, Richardson BA, John-Stewart G, Nduati R, Overbaugh J.  Passively acquired antibody–dependent cellular cytotoxicity (ADCC) activity in HIV-infected infants is associated with reduced mortality.  Cell Host& Microbe 17: 500-506, 2015.
PubMed Abstract

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