AID Logo

Directory >> Chetan Seshadri, MD

Faculty

Contact Information

Chetan Seshadri, MD

  • Acting Instructor, Division of Allergy and Infectious Diseases, Department of Medicine
    University of Washington

  • Associate Medical Staff
    University of Washington Medical Center and Harborview Medical Center

Dr. Seshadri's research focuses on the human immune response to Mycobacterium tuberculosis, the bacteria responsible for tuberculosis. By better understanding what factors are responsible for protective immunity, he hopes to contribute to ongoing efforts to develop an effective vaccine. Specifically, his work addresses three questions:

  • Which M. tuberculosis cell-wall associated antigens are targeted by human T-cells during infection?
  • What is the role of T-cell responses to bacterial lipids in the context of CD1 molecules?
  • Why do some people fail to convert their tuberculin skin tests despite frequent and close contact with tuberculosis patients?

Dr. Seshadri currently works in the laboratory of Dr. Thomas Hawn, also in the Division of Allergy and Infectious Diseases. Research methods include basic cellular and molecular immunology as well as high-throughput transcriptional and genetic analysis of affected populations. Dr. Seshadri has active collaborations with investigators in the United States, France, Vietnam, South Africa, and Uganda.


Selected Publications


Seshadri C, Uiso LO, Ostermann J, et al. Low sensitivity of T-cell based detection of tuberculosis among HIV co-infected Tanzanian inpatients. East Afr Med J. 2008; 85(9): 442-9.
PubMed Abstract


Ter Horst B, Seshadri C, Feringa BL, Moody DB, Minnaard AJ. Asymmetric synthesis and structure elucidation of a glycerophospholipid from Mycobacterium tuberculosis. J Lipid Res. 2010; 51(5): 1017-22.
PubMed Abstract


Drage MG, Tsai HC, Pecora ND, Cheng TY, Arida AR, Rojas RE, Seshadri C, et al. Mycobacterium tuberculosis lipoprotein LprG (Rv1411c) is a glycolipid carrier and delivers triacylated glycolipids to Toll-like receptor 2. Nat Struct Mol Biol. 2010; 17(9): 1088-95.
PubMed Abstract


Kasmar AG, van Rhijn I, Cheng TY, Turner M, Seshadri C, et al. CD1b tetramers bind aß T cell receptors to identify a mycobacterial glycolipid-reactive T cell repertoire in humans. J Exp Med. 2011; 208(9): 1741-7.
PubMed Abstract

to top