Corey, Lawrence, MD

Corey, Lawrence, MD
Professor, Laboratory Medicine, Medicine and Microbiology
Head, Program in Infectious Diseases, Fred Hutchinson Cancer Research Center

CONTACT INFORMATION
UW Box 358080
Fred Hutch Cancer Research Center
1100 Fariview Ave N.
D3-100
Seattle, Washington 98109
Phone: (206) 667-6770
Fax: (206) 667-4411
lcorey@u.washington.edu

LINK TO LARRY COREY'S COMMUNITY OF SCIENCE WEB PAGE

CURRENT RESEARCH INTERESTS

Opportunities for research projects in herpesviruses (HSV, CMV, and HHV-8), HIV, and Hepatitis C are available. Both laboratory-based studies of transitional research studies are available. Laboratory-based projects include studies of pathogenesis of T Cell immune responses to HSV among immuno-compromised and immunocompetent patients, studies of CMV infection among bone marrow transplant patients and studies of the virology and immunology of Kaposi's sarcoma associated herpes virus. The HHV-8 program is directed at the cell biology of HHV-8, its replication in mucosal epithelial cells and the interaction between HHV-8 and HIV-1. The HIV program is directed at defining latent reservoirs of infection and recent observations that monocytes appear to be an important reservoir of persistence of HIV.

Klausner RD, Fauci AS, Corey L, Nabel GJ, Gayle H, Berkley S, Haynes BF, Baltimore D, Collins C, Douglas RG, Esparza J, Francis DP, Ganguly NK, Gerberding JL, Johnston MI, Kazatchkine MD, McMichael AJ, Makgoba MW, Pantaleo G, Piot P, Shao Y, Tramont E, Varmus H, Wasserheit JN. The need for a global HIV vaccine enterprise. Science; 300:2036-9, 2003.

Boeckh M, Leisenring W, Riddell SR, Bowden RA, Huang ML, Myerson D, Stevens-Ayers T, Flowers MED, Cunningham T, Corey L. Late cytomegalovirus disease and mortality in allogeneic marrow transplant recipients: importance of viral load and late CMV-specific T cell immunity. Blood 101:407-414, 2003.

Posavad CM, Wald A, Hosken N, Huang ML, Koelle DM, Ashley RL, Corey L. T cell immunity to herpes simplex viruses in seronegative subjects: silent infection of acquired immunity? J Immunol 170:4380-8, 2003.

Zhu T, Muthui D, Holte S, Nickle D, Feng F, Brodie S, Hwangbo Y, Mullins JI, Corey L. Evidence for human immunodeficiency virus type 1 replication in vivo in CD14+ monocytes and its potential role as a source of virus in patients on highly active antiretroviral therapy. J Virol 767:707-16, 2002.

Schacker T, Zeh J, Hu H, Shaughnessy M, Corey L. Changes in plasma HIV-1 RNA associated with HSV reactivation and suppression. J Infect Dis 186:1718-25, 2002.