Farquhar, Carey

Carey Farquhar, M.D., M.P.H
Assistant Professor, Medicine and Epidemiology

CONTACT INFORMATION
International AIDS Research & Training Program (IARTP)
325 Jefferson
Seattle, WA 98104

Phone: (206) 543-4278
Fax: (206) 543-4278
E-mail: cfarq@u.washington.edu

CURRENT RESEARCH INTERESTS

We are currently conducting several studies on mother-to-child HIV-1 transmission, HIV-1 transmission among discordant couples, and couple counseling in the antenatal setting. Our mother-to-child transmission studies explore correlates of immunity in the infant, with a focus on examining basic science questions from an epidemiologic perspective. We have been measuring several innate, cellular, and genetic factors in two large cohorts of mother-infant pairs. These include HIV-1 specific CTL and T helper responses, HLA type, HIV-1 co-receptor mutations, and chemokines in breastmilk and genital secretions. All of our studies take place in Nairobi, Kenya where I travel approximately 3 times per year to work closely with my Kenyan colleagues and University of Washington investigators, post-doctoral fellows, and students who are based in Kenya.

Farquhar C, John-Stewart G. The role of infant immune responses and genetic factors in preventing HIV-1 acquisition and disease progression. Clin Exp Immunol 2003;134:367-377.

Farquhar C, Mbori-Ngacha DA, Bosire RK, Nduati RW, Kreiss JK, John GC. Partner notification by HIV-1 seropositive pregnant women: association with infant feeding decisions. AIDS 2001 Apr 13;15(6): 815-7.

Farquhar C, VanCott TC, Mbori-Ngacha DA, Horani L, Bosire RK, Kreiss JK, Richardson BA, John-Stewart GC. Salivary secretory leukocyte protease inhibitor is associated with reduced transmission of human immunodeficiency virus type 1 through breast milk. J Infect Dis 2002;186:1173-6.

Farquhar C, Rowland-Jones S, Mbori-Ngacha D, Redman M, Lohman B, Slyker J, Otieno P, Obimbo E, Rostron T, Ochieng J, Oyugi J, Bosire R, John-Stewart G. Human leukocyte antigen (HLA) B*18 and protection against mother-to-child HIV-1 transmission. AIDS Res Hum Retro. In press. 2004; 20:692-697.

Farquhar C, Kiarie JN, Richardson BA, Kabura MN, John FN, Nduati RW, Mbori-Ngacha DA, John-Stewart GC. Antenatal couple counseling increases uptake of interventions to prevent HIV-1 transmission. J Acquir Immune Defic Syndr. 2004 Dec 15; 37(5): 1620-1626.

Lohman B, Slyker J, Richardson BA, Farquhar C, Mabuka J, Crudder C, Dong T, Obimbo E, Mbori-Ngacha D, Overbaugh J, Rowland-Jones S, John-Stewart G. Longitudinal assessment of HIV-1 specific interferon gamma responses during the first year of life of HIV-1 infected infants. J Virol. 2005 Jul;79(13):8121-30.

Farquhar C, Nduati R, Haigwood NL, Sutton W, Mbori-Ngacha D, Richardson B, John-Stewart G. High maternal HIV-1 viral load during pregnancy adversely affects placental transfer and infant concentrations of measles IgG antibody. J Acquir Immune Defic Syndr. 2005 Dec 1;40(4):494-7.

Farquhar C, Redman M, Bosire R, Ruzinski J, Lohman B, Piantadosi A, Goodman R, John-Stewart G. CC and CXC chemokines in breastmilk are associated with mother-to-child HIV-1 transmission. Curr HIV Res. 2005 Oct;3(4):361-9.

Gichuhi C, Obimbo E, Mbori-Ngacha D, Mwatha A, Otieno P, Farquhar C, Wariua G, Wamalwa D, Bosire R, John-Stewart G. Predictors of mortality in HIV-1 exposed uninfected infants in Kenya. East Afr. Med. J. 2005 Mar;82(9):447-51.

Farquhar C, John-Stewart GC, John FN, Kabura MN, Kiarie JN. Pediatric HIV-1 vaccine trial acceptability among mothers in Kenya. AIDS Res Hum Retro 2006. In press.

Balkus J, Bosire R, John-Stewart G, Mbori-Ngacha D, Schiff M, Wamalwa D, Gichuhi C, Obimbo E, Wariua G, Farquhar C, High Uptake of Post-Partum Hormonal Contraception among HIV-1-seropositive Women in Kenya, Sexually Transmitted Disease, in press.