Dr. Gottlieb has two main research interests:  

1. He is the PI of a study on the effect of antiretroviral therapy (ART) on HIV-2 disease outcomes, emergence of drug resistance, and genital shedding in Senegal, West Africa. He is also involved in understanding the differences between the natural history, clinical, immunologic and virologic aspects of HIV-1 and HIV-2 infection.  In addition, he has been studying the effects of dual infection with HIV-1 and HIV-2 on disease outcomes. This work is an ongoing collaborative effort between the UW and the University of Dakar, Senegal, since the early 1990’s.
    

2. He is a Co-investigator in a study to understand the occurrence and outcome of infection with more than one strain of HIV-1.  Dual HIV-1 infection (both Co- and Super-infection) as been associated with higher viral loads, faster rate of CD4 decline, and more rapid progression to AIDS. The “Superinfection Project” is a collaborative effort, between Jim Mullins’ group at the UW and the MACS cohort, to elucidate the virologic and host factors associated with dual infection.