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Henderson, William, MD
Professor of Medicine
Head, Allergy Section, Department of Medicine, Division of Allergy &
Infectious Diseases
CONTACT INFORMATION
University of Washington
Division of Allergy and Infectious Diseases
Box 358050
1959 NE Pacific Street
Seattle, WA 98195-6523
Phone: (206) 543-3780
Fax: (206) 685-9318
joangb@u.washington.edu
LINK
TO WILL HENDERSON'S COMMUNITY OF SCIENCE WEB PAGE
CURRENT RESEARCH
Dr. Henderson is Director of the University of Washington Allergy and Immunology Training Program. Dr. Henderson conducts research on mast cell and eosinophil biology and function and their formation of leukotrienes potent 5-lipoxygenase products of arachidonic acid metabolism. Current research examines the pathogenesis of asthma. A murine model of asthma in which allergic airway inflammation, remodeling, and hyperreactivity develop has been established in Dr. Henderson's laboratory. Specific goals are to define by gene activation key mechanisms (eicosanoids, Th1/Th2 cytokines, adhesion molecules) in the development and maintenance of allergic pulmonary disease. Immunologic, biochemical, and molecular biologic approaches are employed in these studies with a focus on functional genomics and proteomics.
PUBLICATIONS
Nguyen C, Teo J-L, Matsuda A, Eguchi M, Chi E, Henderson WR Jr, Kahn M. Chemogenomic identification of Ref-1/AP-1 as a novel therapeutic target for asthma. Proc Natl Acad Sci USA, 100:1169-73, 2003.
Henderson WR Jr, Tang L-O, Chu S-J, Tsao S-M, Chiang GKS, Jones F, Jonas M, Pae C, Chi EY. A role for cysteinyl leukotrienes in airway remodeling in a mouse model of asthma. Am J Respir Crit Care Med 165:108-16, 2002.
Oh S-W, Pae CI, Lee D-K, Jones F, Chiang GKS, Kim H-O, Moon S-H, Cao B, Ogbu C, Jeong K-W, Kozu G, Nakanishi H, Kahn M, Chi EY,
Henderson WR Jr. Tryptase inhibition blocks airway inflammation in mouse asthma model. J Immunol 168:1992-2000, 2002.
Henderson WR Jr, Chi EY, Teo J-L, Nguyen C, Kahn M. A small molecule inhibitor of redox-regulated NF-?B and activator protein-1 transcription blocks allergic airway inflammation in a mouse asthma model. J Immunol, 169:5294-9, 2002.
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