Jairam Lingappa, M.D., Ph.D.
Medical Director, Partners in Prevention Study
Associate Director, International Clinical Research Center
Assistant Professor, Department of Medicine
Assistant Professor, Department of Global Health
Adjunct Assistant Professor, Pediatrics

CONTACT INFORMATION
University of Washington
Box 359927
Seattle, WA 98195-9927

901 Boren Avenue, Suite 1600 (mail to Suite 1300)
Seattle, Washington 98104
Phone: (206) 520-3822
Fax: (206) 520-3831
E-mail: lingappa@u.washington.edu 

CURRENT RESEARCH INTERESTS

Dr. Lingappa’s research focuses using clinical research studies to better understand host defense factors in infectious diseases. Currently he is medical director and co-investigator of a large multisite clinical trial in Africa evaluating suppression of genital herpes (HSV-2) to reduce HIV transmission; and co-investigator on a second large multisite clinical trial of pre-exposure antiretroviral prophylaxis to reduce HIV transmission.  Epidemiologic data and clinical specimens from these and other clinical studies are stored in the UW Department of Global Health International Clinical Research Center (ICRC).  Collaborating with specialty immunology and genomics labs at the UW and elsewhere, Dr. Lingappa uses these specimens and data to conduct translational scientific investigations into the role of host genomic and immunologic factors and viral co-infections on HIV and other infections.

PUBLICATIONS

Lingappa, J.R., Lambdin, B., Bukusi, B. et al for the Partners HSV-2 Study Group.  Prevalence of HIV-1 Discordance in Eastern and Southern Africa and Impact on Enrollment into an HIV-1 Prevention Clinical Trial, PLoS ONE, 2008, Jan 9, 3(1), e1411

Lingappa J and  Celum C.  Clinical and Therapeutic Issues for HSV-2 and HIV Co-Infection.  Drugs 2007, 67(2)155-74

Tong S, Lingappa JR, Chen Q, et al., Direct sequencing of SARS-coronavirus S and N genes from clinical specimens shows limited variation. J Infect Dis 2004 Sep 15; 190(6)1127-31. Epub 2004 Aug 17.

Lingappa J, Kuffner T, Tappero J,. et al. HLA-DQ6 and ingestion of contaminated water: possible gene-environment interaction in an outbreak of Leptospirosis. Genes Immun. 2004 May; 5(3):197-202.

Lingappa JR, McDonald LC, Simone P, Parashar UD. Wresting SARS from uncertainty. Emerg Infect Dis  2004 Feb; 10(2):167-70.

Keeler N and Lingappa J. Severe acute respiratory syndrome: public health response and clinical practice update for an emerging disease. Curr Opin Pediatr February 2004; 16(1):61-9.

 Agrawal A, Lingappa J, Leppla SH, et al. Impairment of dendritic cells and adaptive immunity by anthrax lethal toxin. Nature 2003 Jul 17; 424(6946): 329-34.

Lingappa JR, Al-Rabeah AM, Hajjeh R. et al., Serogroup W-135 Meningococcal Disease during the Hajj, 2000. Emerg. Inf. Dis. J 2003; 9(6): 665-71.

Pulendran B , Lingappa J, Kennedy  M,. et al. Developmental pathways of dendritic cells in vivo: distinct function, phenotypes and localization of dendritic cell subsets in FLT3-ligand treated mice.  Journal of Immunology 1998; 159, 2222-31.