M. Juliana McElrath MD, Ph.D.
Professor of Medicine
Member, Fred Hutchinson Cancer Research Center
Associate Head, FHCRC Program in Infectious Diseases
Director, FHCRC/UW HIV-1 Vaccine Evaluation Unit

CONTACT INFORMATION
University of Washington
Box 358080
1959 NE Pacific Street
Seattle, Washington 98195

Phone: (206) 667-6704
Fax: (206) 667-4411
kd@u.washington.edu

LINK TO JULIE MCELRATH'S COMMUNITY OF SCIENCE WEB PAGE

CURRENT RESEARCH INTERESTS

 

Our laboratory is interested in defining the cellular immune responses that may correlate with prevention, clearance or control of HIV-1 infection. Studies, both domestic and international (Peru, South Africa, Senegal), include evaluation of T helper and cytotoxic cell responses in individuals with early HIV infection, in uninfected persons following vaccination, and in individuals with multiple HIV exposures who remain uninfected. We are devoting increasing efforts toward defining mucosal cellular immune responses as a model for investigating immunity to sexually transmitted diseases

 

PUBLICATIONS

Musey L, Ding Y, Cao J, Lee J, Galloway C, Yuen A, Jerome KR, McElrath MJ. Ontogeny and specificities of mucosal and blood HIV-1-specific CD8+ cytotoxic T lymphocytes. J Virol 77:291-300, 2003.

Russell N, Hudgens M, Ha R, Havenar-Daughton C, McElrath MJ. Moving to HIV-1 vaccine efficacy trials: defining T cell responses as potential correlates of immunity. J Infect Dis 187:226-42, 2003.

Malhotra U, Holte S, Zhu T, Delpit E, Huntsberry C, Sette A, Shankarappa R, Maenza J, Corey L,. McElrath MJ. Early induction and maintenance of env-specific T-helper cells following HIV-1 infection. J Virol 77:2663-74, 2003.

Zhu T, Corey L, Hwangbo Y, Lee J, Learn GH, Mullins JI, McElrath MJ. Persistence of extraordinarily low levels of genetically homogeneous HIV-1 in exposed seronegative individuals. J Virol 77:6108-16, 2003.

Cao J, McNevin J, Holte S, Fink L, Corey L, McElrath MJ. Comprehensive analysis of HIV-1-specific IFN-g-secreting CD8+ T cells in primary HIV-1 infection. J Virol 77:6867-78, 2003.

Hladik F, Desbien A, Lang J, Wang L, Ding Y, Holte S, Wilson A, Xu Y, Moerbe M, Schmechel S, McElrath MJ. Most highly exposed seronegative men lack HIV-1-specific IFN-y secreting T cells. J Immunol, in press.