Mullins, James, Ph.D.
Professor, Microbiology, School of Medicine.
Professor, Allergy and Infectious Diseases, Department of Medicine
Adjunct Professor, Department of Laboratory Medicine, School of Medicine.

CONTACT INFORMATION
University of Washington
Box 358070
Rosen Building
Seattle, Washington 98109-8070

Phone: (206) 732-6163
Fax: (206) 616-6749
jmullins@u.washington.edu
Personal Home Page

LINK TO JAMES MULLINS' COMMUNITY OF SCIENCE WEB PAGE


CURRENT RESEARCH INTERESTS

The Mullins lab uses the techniques of molecular, computational and virus biology to provide basic insights into the HIV-human host relationship. Our goals are to assist the development of understanding, therapies, and vaccines to help fight AIDS. We use a variety of techniques to understand the implications of HIV's extraordinary genetic diversity for the pathogenesis of AIDS and with the intention of applying this information to the development of therapies that are more effective and vaccines. These techniques include virology, molecular biological, phylogenetic and statistical analysis of nucleotide sequences, and high-throughput array analysis of cellular transcription. 

PUBLICATIONS

van 't Wout AB, Lehrman GK, Mikheeva SA, O'Keeffe GC, Katze MG, Bumgarner RE, Geiss GK, Mullins JI. Cellular gene expression upon human immunodeficiency virus type 1 infection of CD4(+)-T cell lines. J Virol 77:1392-402, 2003.

Frenkel LM, Wang Y, Learn GH, McKernan JL, Ellis GM, Mohan KM, Holte SE, De Vange SM, Pawluk DM, Melvin AJ, Lewis PF, Heath LM, Beck IA, Mahalanabis M, Naugler WE, Tobin NH, Mullins JI. Multiple viral genetic analyses detect low-level human immunodeficiency virus type 1 replication during effective highly active antiretroviral therapy. J Virol 77:5721-30, 2003.

Nickle DC, Jensen MA, Gottlieb GS, Shriner D, Learn GH, Rodrigo AG, Mullins JI. Consensus and ancestral state HIV vaccines. Science 299:1515-8, 2003.

Nickle DC, Jensen MA, Shriner D, Brodie SJ, Frenkel LM, Mittler JE, Mullins JI. Evolutionary indicators of human immunodeficiency virus type 1 reservoirs and compartments. J Virol 77:5540-6, 2003.

Shriner D, Nickle DC, Jensen MA, Mullins JI. The potential impact of recombination on sitewise approaches for detecting positive natural selection. Genet Res 81:115-21, 2003.