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M.D., Cum Laude, Harvard Medical School, Boston, Massachusetts,
1971
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Medical Resident, University of Washington Affiliated
Hospitals, Seattle, WA., 1971-73
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Epidemiologist, Hospital Infections Branch, Bacterial
Diseases Division, Centers for Disease Control, Atlanta, Georgia,
1973-74
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Chief, Hospital Infections Branch, Centers for Disease
Control, Atlanta, Georgia, 1974-75
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Chief Medical Resident, Harborview Medical Center,
University of Washington Affiliated Hospitals, Seattle, WA, 1976-77
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Senior Fellow in Infectious Diseases, Harborview Medical
Center, University of Washington Affiliated Hospitals, Seattle, WA,
1977-7
CURRENT RESEARCH INTERESTS
We are studying the epidemiology and pathogenesis of bacterial genitourinary tract infections, especially urinary tract infections due to E. coli and genital infections due to C. trachomatis. With respect to urinary tract infections, we are conducting two large NIH-sponsored studies aimed at elucidating the factors that predispose young women to recurrent UTI. The specific roles of host genetic factors, host anatomy and physiology, bacterial virulence determinants, and exogenous exposures such as antimicrobials and spermicides are being studied. A number of other epidemiological and laboratory studies addressing the epidemiology and pathogenesis of UTI are also ongoing, including study of antimicrobial resistance in community-acquired UTI.
With respect to C. trachomatis infections, we are utilizing molecular diagnostic tests for C. trachomatis (as well as serotyping and genotyping) to elucidate the epidemiology of sexually-transmitted C. trachomatis infections. We are also studying the application of these tests in prevention programs. In the laboratory, we are studying the pathogenesis of C. trachomatis urogenital infections, particularly in the role of inclusion membrane proteins in the pathobiology of chlamydial infection. Comparative chlamydial genomic sequencing and microarray analysis form the basis of these studies.
Xia M, Bumgarner RE, Lampe MF,
Stamm WE. Chlamydia trachomatis infection alters host cell transcription in diverse cellular pathways. J Infect Dis 187:424-34, 2003.
Rockey DD, Viratyosin W, Bannantime JP, Suchland RJ, Stamm WE. Diversity within inc genes of clinical Chlamydia trachomatis variant isolates that occupy non-fusogenic inclusions. Microbiol 148:2497-505, 2002.
Gupta K, Hooton TM, Roberts PL, Stamm WE. Patient-initiated treatment of uncomplicated recurrent urinary tract infection in young women. Ann Intern Med 135:9-16, 2001.
Suchland RJ, Rockey DD, Bannantime JP, Stamm WE. Isolates of Chlamydial trachomatis that occupy nonfusogenic inclusions lack IncA, a protein localized to the inclusion membrane. Infect Immun 68:360-7, 2000.
Hooton TM, Scholes D, Stapleton AE, Roberts PL, Winter C, Gupta K, Samadpour M,
Stamm WE. A prospective study of asymptomatic bacteriuria in sexually active young women. N Engl J Med 343:992-7, 2000.
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